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pro vyhledávání: '"Young Bong Choi"'
Autor:
Mai Tram Vo, Young Bong Choi
Publikováno v:
Autophagy Reports, Vol 2, Iss 1 (2023)
ABSTRACTViral control of mitochondria via mitophagy has a dampening effect on mitochondrion-mediated innate immune responses. We previously found that human herpesvirus 8 (HHV-8) could activate mitophagy via its lytic gene product vIRF-1 (viral inter
Externí odkaz:
https://doaj.org/article/d60ef35504384625b030468ea9507687
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Impaired removal of damaged mitochondria by mitophagy can activate innate immune signaling, but impact on virus replication remains unclear. Here the authors show that viral IRF-1 of human herpesvirus 8 activates mitophagy via interaction with the mi
Externí odkaz:
https://doaj.org/article/0190118766754883975cadf68938321e
Autor:
Suchitra Mohanty, Teng Han, Young Bong Choi, Alfonso Lavorgna, Jiawen Zhang, Edward William Harhaj
Publikováno v:
PLoS Pathogens, Vol 16, Iss 12, p e1008504 (2020)
Human T-cell leukemia virus type 1 (HTLV-1) is the etiological agent of adult T-cell leukemia/lymphoma (ATLL), and the neurological disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The HTLV-1 Tax protein persistently activ
Externí odkaz:
https://doaj.org/article/f2721a3827564529a2a2bb0fbdebd3a9
Autor:
Mai Tram Vo, Young Bong Choi
Publikováno v:
Viruses, Vol 13, Iss 5, p 820 (2021)
Selective autophagy has emerged as a key mechanism of quality and quantity control responsible for the autophagic degradation of specific subcellular organelles and materials. In addition, a specific type of selective autophagy (xenophagy) is also ac
Externí odkaz:
https://doaj.org/article/b66887f126bc4d24a98fc7b4aefe5a95
Publikováno v:
PLoS Pathogens, Vol 14, Iss 5, p e1007058 (2018)
Human herpesvirus 8 (HHV-8) is causally related to human malignancies. HHV-8 latent viral FLICE-inhibitory protein (vFLIP) is a viral oncoprotein that is linked to pathogenesis, but how its expression is regulated is largely unknown. In an attempt to
Externí odkaz:
https://doaj.org/article/5e3bf8fd197c4c5fb6db88614e710082
Autor:
Young Bong Choi, Edward William Harhaj
Publikováno v:
PLoS Pathogens, Vol 10, Iss 10, p e1004458 (2014)
The human T-cell leukemia virus type 1 (HTLV-1) Tax protein hijacks the host ubiquitin machinery to activate IκB kinases (IKKs) and NF-κB and promote cell survival; however, the key ubiquitinated factors downstream of Tax involved in cell transform
Externí odkaz:
https://doaj.org/article/f0939049ff2547e4813adfe8c09d96ec
Publikováno v:
PLoS Pathogens, Vol 8, Iss 6, p e1002748 (2012)
Viral replication efficiency is in large part governed by the ability of viruses to counteract pro-apoptotic signals induced by infection of host cells. For HHV-8, viral interferon regulatory factor-1 (vIRF-1) contributes to this process in part via
Externí odkaz:
https://doaj.org/article/b44c08b18eb64a55a53041abb6607553
Autor:
Young Bong Choi, John Nicholas
Publikováno v:
PLoS Pathogens, Vol 6, Iss 8, p e1001031 (2010)
Viral replication efficiency is in large part governed by the ability of viruses to counteract pro-apoptotic signals induced by infection of the host cell. Human herpesvirus 8 (HHV-8) uses several strategies to block the host's innate antiviral defen
Externí odkaz:
https://doaj.org/article/1631d340a1c64df8bd938709837471ff
Publikováno v:
Polymer Korea. 47:171-180
Publikováno v:
Autophagy
TAX1BP1 is a selective macroautophagy/autophagy receptor that plays a central role in host defense to pathogens and in regulating the innate immune system. TAX1BP1 facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimu