LP-099 High genetic risk loads increase the risk of lupus nephritis in Koreans

Autor: Sang-Cheol Bae, Kwangwoo Kim, Young-Chang Kwon, So-Young Bang, Eunji Ha, Dae-Hyun Yoo, Won Tae Chung, Jung-Min Shin, Hye-Soon Lee, Dae Jin Park, Hyuk-Hee Kwon, Young Bin Joo

Publikováno v: Lupus Science and Medicine, Vol 10, Iss Suppl 1 (2023)

Externí odkaz: https://doaj.org/article/ea027a7e46d24728aecee55d6cdd94dd

Update on the Genetics of Systemic Lupus Erythematosus: Genome-Wide Association Studies and Beyond

Autor: Young-Chang Kwon, Sehwan Chun, Kwangwoo Kim, Anselm Mak

Publikováno v: Cells, Vol 8, Iss 10, p 1180 (2019)

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of complex etiology that primarily affects women of childbearing age. The development of SLE is attributed to the breach of immunological tolerance and the interaction between SLE-sus

Externí odkaz: https://doaj.org/article/854ee5faca0540028b67dcfcecfe0835

Biological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study

Autor: Xianyong, Yin, Kwangwoo, Kim, Hiroyuki, Suetsugu, So-Young, Bang, Leilei, Wen, Masaru, Koido, Eunji, Ha, Lu, Liu, Yuma, Sakamoto, Sungsin, Jo, Rui-Xue, Leng, Nao, Otomo, Young-Chang, Kwon, Yujun, Sheng, Nobuhiko, Sugano, Mi Yeong, Hwang, Weiran, Li, Masaya, Mukai, Kyungheon, Yoon, Minglong, Cai, Kazuyoshi, Ishigaki, Won Tae, Chung, He, Huang, Daisuke, Takahashi, Shin-Seok, Lee, Mengwei, Wang, Kohei, Karino, Seung-Cheol, Shim, Xiaodong, Zheng, Tomoya, Miyamura, Young Mo, Kang, Dongqing, Ye, Junichi, Nakamura, Chang-Hee, Suh, Yuanjia, Tang, Goro, Motomura, Yong-Beom, Park, Huihua, Ding, Takeshi, Kuroda, Jung-Yoon, Choe, Chengxu, Li, Hiroaki, Niiro, Youngho, Park, Changbing, Shen, Takeshi, Miyamoto, Ga-Young, Ahn, Wenmin, Fei, Tsutomu, Takeuchi, Jung-Min, Shin, Keke, Li, Yasushi, Kawaguchi, Yeon-Kyung, Lee, Yong-Fei, Wang, Koichi, Amano, Dae Jin, Park, Wanling, Yang, Yoshifumi, Tada, Yu Lung, Lau, Ken, Yamaji, Zhengwei, Zhu, Masato, Shimizu, Takashi, Atsumi, Akari, Suzuki, Takayuki, Sumida, Yukinori, Okada, Koichi, Matsuda, Keitaro, Matsuo, Yuta, Kochi, Kazuhiko, Yamamoto, Koichiro, Ohmura, Tae-Hwan, Kim, Sen, Yang, Takuaki, Yamamoto, Bong-Jo, Kim, Nan, Shen, Shiro, Ikegawa, Hye-Soon, Lee, Xuejun, Zhang, Chikashi, Terao, Yong, Cui, Sang-Cheol, Bae

Publikováno v: Annals of the Rheumatic Diseases. 81:1273-1280

ObjectiveGenome-wide association studies (GWAS) have identified >100 risk loci for systemic lupus erythematosus (SLE), but the disease genes at most loci remain unclear, hampering translation of these genetic discoveries. We aimed to prioritise genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc23aefa6fc3463b28c74e1115214ed
https://doi.org/10.1136/annrheumdis-2022-222345

Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus

Autor: Yeon-Kyung Lee, Kohei Karino, Dae Jin Park, Xiaoting Chen, Xiaodong Zheng, Dong-Qing Ye, So-Young Bang, Leilei Wen, Tae-Hwan Kim, Takuaki Yamamoto, Yukinori Okada, Young Mo Kang, Sreeja Parameswaran, Xuejun Zhang, Cheng-Xu Li, Eunji Ha, Sang Cheol Bae, Hiroyuki Suetsugu, Koichi Amano, Tsutomu Takeuchi, Takayuki Sumida, Ken Yamaji, Hye-Soon Lee, Yuanjia Tang, Seung-Cheol Shim, Viktoryia Laurynenka, Sen Yang, Wanling Yang, Yujun Sheng, Xianyong Yin, Koichi Matsuda, Keitaro Matsuo, Akari Suzuki, Chang-Hee Suh, Weiran Li, Kwangwoo Kim, Lu Liu, Kyungheon Yoon, Bong-Jo Kim, Mi Yeong Hwang, Takeshi Kuroda, Shruti Eswar, Koichiro Ohmura, Keke Li, Tomoya Miyamura, Shiro Ikegawa, Hanan Salim, Yuta Kochi, Chikashi Terao, Won Tae Chung, Sungsin Jo, Changbing Shen, Kazuhiko Yamamoto, Daisuke Takahashi, Mengwei Wang, Masaya Mukai, Minglong Cai, Matthew T. Weirauch, Nao Otomo, Kazuyoshi Ishigaki, Yuma Sakamoto, Nan Shen, Hiroaki Niiro, Takashi Atsumi, Yong-Fei Wang, Junichi Nakamura, Young-Chang Kwon, Leah C. Kottyan, Yong Cui, John B. Harley, Goro Motomura, Masato Shimizu, Yasushi Kawaguchi, Nobuhiko Sugano, Rui-Xue Leng, Jung-Yoon Choe, Takeshi Miyamoto, Yong Beom Park, Jung-Min Shin, Masaru Koido, G.Y. Ahn, Huihua Ding, Wen-Min Fei, Shin-Seok Lee, Young-Ho Park, He Huang, Yoshifumi Tada

Publikováno v: Annals of the Rheumatic Diseases

ObjectiveSystemic lupus erythematosus (SLE), an autoimmune disorder, has been associated with nearly 100 susceptibility loci. Nevertheless, these loci only partially explain SLE heritability and their putative causal variants are rarely prioritised,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1df8536416d1f595b9d0eb715661c09
https://doi.org/10.1136/annrheumdis-2020-219209

cdc37 is essential for JNK pathway activation and wound closure in Drosophila

Autor: Chan Wool Lee, Min Yoon Park, Kwang Min Choe, Young-Chang Kwon, Youngbin Lee

Publikováno v: Molecular Biology of the Cell

Wound closure in the Drosophila larval epidermis mainly involves nonproliferative, endocyling epithelial cells. Consequently, it is largely mediated by cell growth and migration. We discovered that both cell growth and migration in Drosophila require

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352defa59aec5382b0f8ce218fd39d01
http://europepmc.org/articles/PMC6761768