Secreted HMGB1 from Wnt activated intestinal cells is required to maintain a crypt progenitor phenotype

Autor: Reed, Karen R, Song, Fei, Young, Maddy A, Hassan, Nurudeen, Antoine, Daniel J, Gemici, Nesibe-Princess B, Clarke, Alan R, Jenkins, John R

Publikováno v: Reed, K R, Song, F, Young, M A, Hassan, N, Antoine, D J, Gemici, N-P B, Clarke, A R & Jenkins, J R 2016, ' Secreted HMGB1 from Wnt activated intestinal cells is required to maintain a crypt progenitor phenotype ', Oncotarget, vol. 7, no. 32, pp. 51665-51673 . https://doi.org/10.18632/oncotarget.10076

BACKGROUND AND AIMS: Colorectal cancer (CRC) arises via multiple genetic changes. Mutation of the tumour suppressor gene APC, a key regulator of Wnt signalling, is recognised as a frequent early driving mutation in CRC. We have previously shown that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::abfa5d852c30aae37caba945919a37da
https://hdl.handle.net/20.500.11820/8d349418-9367-4dc0-bde9-a7072df00d4d