Catalytic enantioselective synthesis of perfluoroalkyl-substituted β-lactones via a concerted asynchronous [2 + 2] cycloaddition: a synthetic and computational study† †Electronic supplementary information (ESI) available: Experimental procedures, product characterisation data (mpt, NMR, IR, HRMS, [α]D, HPLC), traces (1H, 13C, 19F NMR, HPLC), X-ray crystallographic data (CCDC 1886142, CCDC 1886143 and CCDC 1886144), coordinates, thermal corrections and energies of all computed structures. CCDC 1886142–1886144. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c9sc00390h

Autor: Barrios Antúnez, Diego-Javier, Greenhalgh, Mark D., Brueckner, Alexander C., Walden, Daniel M., Elías-Rodríguez, Pilar, Roberts, Patrick, Young, Benjamin G., West, Thomas H., Slawin, Alexandra M. Z., Ha-Yeon Cheong, Paul, Smith, Andrew D.

Publikováno v: Chemical Science

A study into the Lewis base-catalysed enantioselective synthesis of polyfluorinated β-lactones.
The enantioselective preparation of a range of perfluoroalkyl-substituted β-lactones through an isothiourea (HyperBTM) catalysed reaction using sym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2cd0eb9b577fb2386d23b9708335ffdb
http://europepmc.org/articles/PMC6585878

Towards geospatially-resolved public-health surveillance via wastewater sequencing.

Autor: Tierney BT; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA. btt4001@med.cornell.edu.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA. btt4001@med.cornell.edu., Foox J; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA., Ryon KA; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA., Butler D; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA., Damle N; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA., Young BG; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA., Mozsary C; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA., Babler KM; Department of Human Genetics, University of Utah, Salt Lake City, UT, USA.; Department of Chemical, Environmental, and Materials Engineering, University of Miami, Coral Gables, FL, USA., Yin X; Department of Chemical, Environmental, and Materials Engineering, University of Miami, Coral Gables, FL, USA., Carattini Y; Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL, USA., Andrews D; Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL, USA., Lucaci AG; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA., Solle NS; Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA., Kumar N; Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA., Shukla B; Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA., Vidović D; Department of Molecular & Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA.; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA., Currall B; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA., Williams SL; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA., Schürer SC; Department of Molecular & Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL, USA.; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.; Institute for Data Science & Computing, University of Miami, Coral Gables, FL, USA., Stevenson M; Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA., Amirali A; Department of Chemical, Environmental, and Materials Engineering, University of Miami, Coral Gables, FL, USA., Beaver CC; Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA., Kobetz E; Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA., Boone MM; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA., Reding B; Environmental Health and Safety, University of Miami, Miami, FL, USA., Laine J; Environmental Health and Safety, University of Miami, Miami, FL, USA., Comerford S; Environmental Health and Safety, University of Miami, Miami, FL, USA., Lamar WE; Division of Occupational Health, Safety & Compliance, University of Miami Health System, Miami, FL, USA., Tallon JJ Jr; Facilities and Operations, University of Miami, Coral Gables, FL, USA., Wain Hirschberg J; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA., Proszynski J; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA., Al Ghalith G; Seed Health, Venice, CA, USA., Can Kurt K; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA., Sharkey ME; Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL, USA., Church GM; Harvard Medical School and the Wyss Institute, Boston, MA, USA., Grills GS; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA., Solo-Gabriele HM; Department of Chemical, Environmental, and Materials Engineering, University of Miami, Coral Gables, FL, USA. hmsolo@miami.edu., Mason CE; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA. chm2042@med.cornell.edu.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA. chm2042@med.cornell.edu.; The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, USA. chm2042@med.cornell.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Sep 27; Vol. 15 (1), pp. 8386. Date of Electronic Publication: 2024 Sep 27.