Angiotensin II induces reactive oxygen species, DNA damage, and T-cell apoptosis in severe COVID-19

Autor: Kundura, Lucy, Gimenez, Sandrine, Cezar, Renaud, André, Sonia, Younas, Mehwish, Lin, Yea-Lih, Portalès, Pierre, Lozano, Claire, Boulle, Charlotte, Reynes, Jacques, Vincent, Thierry, Mettling, Clément, Pasero, Philippe, Muller, Laurent, Lefrant, Jean-Yves, Roger, Claire, Claret, Pierre-Géraud, Duvnjak, Sandra, Loubet, Paul, Sotto, Albert, Tran, Tu-Anh, Estaquier, Jérôme, Corbeau, Pierre

Publikováno v: In The Journal of Allergy and Clinical Immunology September 2022 150(3):594-603

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Longitudinal immune profiling reveals distinct features of COVID-19 pathogenesis

Autor: Mann, Elizabeth R., Menon, Madhvi, Knight, Sean Blandin, Konkel, Joanne E., Jagger, Christopher, Shaw, Tovah N., Krishnan, Siddharth, Rattray, Magnus, Ustianowski, Andrew, Bakerly, Nawar Diar, Dark, Paul, Lord, Graham, Simpson, Angela, Felton, Timothy, Ho, Ling Pei, Feldmann, Marc, Grainger, John R., Hussell, Tracy, Ahmed, Rohan, Shuwa, Halima Ali, Avery, Miriam, Birchall, Katharine, Brand, Oliver, Charsley, Evelyn, Chenery, Alistair, Chew, Christine, Clark, Richard, Connolly, Emma, Connolly, Karen, Dawson, Simon, Durrans, Laura, Durrington, Hannah, Egan, Jasmine, Fox, Claire, Francis, Helen, Franklin, Miriam, Glasgow, Susannah, Godfrey, Nicola, Gray, Kathryn J., Grundy, Seamus, Guerin, Jacinta, Hackney, Pamela, Iqbal, Mudassar, Hayes, Chantelle, Hardy, Emma, Harris, Jade, John, Anu, Jolly, Bethany, Kästele, Verena, Khan, Saba, Lindergard, Gabriella, Lui, Sylvia, Lowe, Lesley, Mathioudakis, Alex G., McClure, Flora A., Mitchell, Joanne, Moizer, Clare, Moore, Katrina, Morgan, David, Moss, Stuart, Baker, Syed Murtuza, Oliver, Rob, Padden, Grace, Parkinson, Christina, Pearmain, Laurence, Phuychareon, Mike, Saha, Ananya, Salcman, Barbora, Scott, Nicholas A., Sharma, Seema, Shaw, Jane, Shaw, Joanne, Shepley, Elizabeth, Smith, Lara, Stephan, Simon, Stephens, Ruth, Tavernier, Gael, Tudge, Rhys, Wareing, Louis, Warren, Roanna, Williams, Thomas, Willmore, Lisa, Younas, Mehwish, Horsley, Alex, Harrison, Tim, Porter, Joanna, Djukanovic, Ratko, Marciniak, Stefan, Brightling, Chris, McGarvey, Lorcan, Davies, Jane

Publikováno v: Mann, E R, Menon, M, Knight, S B, Konkel, J E, Jagger, C, Shaw, T N, Krishnan, S, Rattray, M, Ustianowski, A, Bakerly, N D, Dark, P, Lord, G, Simpson, A, Felton, T, Ho, L P, Feldmann, M, Grainger, J R, Hussell, T, Ahmed, R, Shuwa, H A, Avery, M, Birchall, K, Brand, O, Charsley, E, Chenery, A, Chew, C, Clark, R, Connolly, E, Connolly, K, Dawson, S, Durrans, L, Durrington, H, Egan, J, Fox, C, Francis, H, Franklin, M, Glasgow, S, Godfrey, N, Gray, K J, Grundy, S, Guerin, J, Hackney, P, Iqbal, M, Hayes, C, Hardy, E, Harris, J, John, A, Jolly, B, Kästele, V, Khan, S, Lindergard, G, Lui, S, Lowe, L, Mathioudakis, A G, McClure, F A, Mitchell, J, Moizer, C, Moore, K, Morgan, D, Moss, S, Baker, S M, Oliver, R, Padden, G, Parkinson, C, Pearmain, L, Phuychareon, M, Saha, A, Salcman, B, Scott, N A, Sharma, S, Shaw, J, Shaw, J, Shepley, E, Smith, L, Stephan, S, Stephens, R, Tavernier, G, Tudge, R, Wareing, L, Warren, R, Williams, T, Willmore, L, Younas, M, Horsley, A, Harrison, T, Porter, J, Djukanovic, R, Marciniak, S, Brightling, C, Ho, L P, McGarvey, L & Davies, J 2020, ' Longitudinal immune profiling reveals distinct features of COVID-19 pathogenesis ', medRxiv . https://doi.org/10.1101/2020.06.13.20127605

BackgroundThe pathogenesis of COVID-19, caused by a novel strain of coronavirus (SARS-CoV-2), involves a complex host-virus interaction and is characterised by an exaggerated immune response, the specific components of which are poorly understood. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4539e05e0421cfb3f4b56751f796ed
https://www.mendeley.com/catalogue/20a7a731-18c8-35f1-8a57-07a06a0a4e47/

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Notch activation on effector T cells increases their sensitivity to Treg cell-mediated suppression through upregulation of TGF-βRII expression

Autor: Yves Levy, Younas Mehwish, Shahul Mouhamad, Sophie Hue, Hassen Kared, Michelle Balbo

Publikováno v: European Journal of Immunology. 42:1796-1803

Notch proteins play an important role in embryonic development and cell-fate decisions. Notch influences also the activation and differentiation of peripheral T cells. Here, we investigated whether Notch signaling modulates the response of effector T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be89891fe3f25ff795789c26035a6c5e
https://doi.org/10.1002/eji.201142330