Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Youn‐Sang Jung"'
Autor:
Mi-Jin An, Ji-Young Kim, Jinho Kim, Dae-Hyun Kim, Geun-Seup Shin, Hyun-Min Lee, Ah-Ra Jo, Yuna Park, Yujeong Hwangbo, Chul-Hong Kim, Mi Jin Kim, Youn-Sang Jung, Jeongkyu Kim, Sangmyung Rhee, Sang-Beom Seo, Jung-Woong Kim
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110380- (2024)
Summary: Histone H3K9 methylated heterochromatin silences repetitive non-coding sequences and lineage-specific genes during development, but how tissue-specific genes escape from heterochromatin in differentiated cells is unclear. Here, we examine ag
Externí odkaz:
https://doaj.org/article/e79b7b2bee11437caa90ff0c0c795808
Autor:
Bongjun Kim, Shengzhe Zhang, Yuanjian Huang, Kyung-Pil Ko, Youn-Sang Jung, Jinho Jang, Gengyi Zou, Jie Zhang, Sohee Jun, Kee-Beom Kim, Kwon-Sik Park, Jae-Il Park
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114286- (2024)
Summary: Tumor cell plasticity contributes to intratumoral heterogeneity and therapy resistance. Through cell plasticity, some lung adenocarcinoma (LUAD) cells transform into neuroendocrine (NE) tumor cells. However, the mechanisms of NE cell plastic
Externí odkaz:
https://doaj.org/article/7beabc5633f54eef9bcd464bc524689b
Autor:
Shengzhe Zhang, Sung Ho Lee, Litong Nie, Yuanjian Huang, Gengyi Zou, Youn‐Sang Jung, Sohee Jun, Jie Zhang, Esther M. Lien, Junjie Chen, Jae‐Il Park
Publikováno v:
Cancer Communications, Vol 43, Iss 1, Pp 159-163 (2023)
Externí odkaz:
https://doaj.org/article/f5ab10a75cbc4938a7ae90dba61d3d84
Autor:
Youn-Sang Jung, Jae-Il Park
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 2, Pp 183-191 (2020)
Cancer: A search for safer signaling targets More effective treatments for cancer could be developed by targeting signaling pathway regulators that are expressed solely in cancer cells. Disruption to a major signaling pathway known as Wnt, which is i
Externí odkaz:
https://doaj.org/article/bb77a696695b4d39b07898608c7fce6f
Autor:
Biyun Zheng, Kyung-Pil Ko, Xuefen Fang, Xiaozhong Wang, Jie Zhang, Sohee Jun, Bong-Jun Kim, Wenyi Luo, Moon Jong Kim, Youn-Sang Jung, Christopher L. Cervantes, Jae-Il Park
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103440- (2021)
Summary: Organoids mimic the physiologic and pathologic events of organs. However, no consensus on esophageal organoid (EO) culture methods has been reached. Moreover, organoid models reproducing esophageal squamous cell carcinoma (ESCC) initiation h
Externí odkaz:
https://doaj.org/article/68eefaa00f0d4a1d8e3b99253eb5f347
Publikováno v:
Cell Reports, Vol 21, Iss 9, Pp 2571-2584 (2017)
Fine control of stem cell maintenance and activation is crucial for tissue homeostasis and regeneration. However, the mechanism of quiescence exit of Tert+ intestinal stem cells (ISCs) remains unknown. Employing a Tert knockin (TertTCE/+) mouse model
Externí odkaz:
https://doaj.org/article/1ec691de2569476b918fb9df5f3cdf24
Autor:
Sohee Jun, Youn-Sang Jung, Han Na Suh, Wenqi Wang, Moon Jong Kim, Young Sun Oh, Esther M. Lien, Xi Shen, Yoshihisa Matsumoto, Pierre D. McCrea, Lei Li, Junjie Chen, Jae-Il Park
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The Wnt/β-catenin signalling pathway contributes to radio resistance in intestinal stem cells but the underlying mechanism is currently unknown. In this study, the authors demonstrate that LIG4, a DNA ligase involved in the DNA repair process, is a
Externí odkaz:
https://doaj.org/article/581765a279824025a9bb4b79da323deb
PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness
Autor:
Xin Wang, Youn-Sang Jung, Sohee Jun, Sunhye Lee, Wenqi Wang, Andrea Schneider, Young Sun Oh, Steven H. Lin, Bum-Joon Park, Junjie Chen, Khandan Keyomarsi, Jae-Il Park
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Stem cells are found in many tumour types and are thought to be partially responsible for cell survival following therapy. Here, the authors show that PCNA-associated factor, PAF, contributes to stemness in breast cancer cells and pharmacological tar
Externí odkaz:
https://doaj.org/article/37476cf6f4614676ad1403d5c4213f50
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 12, Pp 1070-1081 (2014)
Since loss of VHL is frequently detected early phase genetic event in human renal cell carcinoma, pVHL is assumed to be indispensable for suppression of tumor initiation step. However, induction of HIF-1α, target of pVHL E3 ligase, is more adequate
Externí odkaz:
https://doaj.org/article/ca67290d826b40569f59263fccb1ba0d
Autor:
Jae-Il Park, Shengzhe Zhang, Sung Ho Lee, Litong Nie, Yuanjian Huang, Gengyi Zou, Youn-Sang Jung, Sohee Jun, Jie Zhang, Esther Lien, Junjie Chen
Publikováno v:
Cancer Communications. 43:159-163
Lysosomes play vital roles in the degradation and recycling of various macromolecules, protein secretion, energy metabolism, and cell signaling. Increasing evidence suggests that the deregulated lysosomes contribute to tumorigenesis and therapeutic r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1cb165c2d9ca3c0bb7d04a664153dd6
https://doi.org/10.1002/cac2.12382
https://doi.org/10.1002/cac2.12382