Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Youming Xie"'
Autor:
Jian-Pu Zheng, Xiangqin He, Fang Liu, Shuping Yin, Shichao Wu, Maozhou Yang, Jiawei Zhao, Xiaohua Dai, Hong Jiang, Luyi Yu, Qin Yin, Donghong Ju, Claire Li, Leonard Lipovich, Youming Xie, Kezhong Zhang, Hui J. Li, Jiliang Zhou, Li Li
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Abstract Yin Yang 1 (YY1) regulates gene transcription in a variety of biological processes. In this study, we aim to determine the role of YY1 in vascular smooth muscle cell (VSMC) phenotypic modulation both in vivo and in vitro. Here we show that v
Externí odkaz:
https://doaj.org/article/cc7f4842bb50449f8d66b93adfce802c
Autor:
Jie Xu, Alessandra Livraghi-Butrico, Xia Hou, Carthic Rajagopalan, Jifeng Zhang, Jun Song, Hong Jiang, Hong-Guang Wei, Hui Wang, Mohamad Bouhamdan, Jinxue Ruan, Dongshan Yang, Yining Qiu, Youming Xie, Ronald Barrett, Sharon McClellan, Hongmei Mou, Qingtian Wu, Xuequn Chen, Troy D. Rogers, Kristen J. Wilkinson, Rodney C. Gilmore, Charles R. Esther Jr., Khalequz Zaman, Xiubin Liang, Michael Sobolic, Linda Hazlett, Kezhong Zhang, Raymond A. Frizzell, Martina Gentzsch, Wanda K. O’Neal, Barbara R. Grubb, Y. Eugene Chen, Richard C. Boucher, Fei Sun
Publikováno v:
JCI Insight, Vol 6, Iss 1 (2021)
Existing animal models of cystic fibrosis (CF) have provided key insights into CF pathogenesis but have been limited by short lifespans, absence of key phenotypes, and/or high maintenance costs. Here, we report the CRISPR/Cas9-mediated generation of
Externí odkaz:
https://doaj.org/article/ff264f8cd5104415abd1eba07591062e
Autor:
Xiaohua Dai, Devi Thiagarajan, Jingye Fang, Jianbin Shen, Neeraja Priyanka Annam, Zhao Yang, Hong Jiang, Donghong Ju, Youming Xie, Kezhong Zhang, Yan Yuan Tseng, Zhe Yang, Arun K Rishi, Hui J Li, Maozhou Yang, Li Li
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0190191 (2017)
Vascular smooth muscle cell (VSMC) phenotypic modulation is characterized by the downregulation of SMC actin cytoskeleton proteins. Our published study shows that depletion of SM22α (aka SM22, Transgelin, an actin cytoskeleton binding protein) promo
Externí odkaz:
https://doaj.org/article/d298d828945647a2849055ef59946154
Autor:
Tianpeng Zhang, Dhong Hyo Kho, Ying Wang, Yosuke Harazono, Kosei Nakajima, Youming Xie, Avraham Raz
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118448 (2015)
Nonalcoholic steatohepatitis (NASH) is related to metabolic dysregulation and the perturbation of endoplasmic reticulum (ER) homeostasis that frequently develops into hepatocellular carcinoma (HCC). Gp78 is E3 ligase, which regulates endoplasmic reti
Externí odkaz:
https://doaj.org/article/f5eb3982a79b4fcda3532c9150203555
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e9877 (2010)
BACKGROUND: The proteasome homeostasis in Saccharomyces cerevisiae is regulated by a negative feedback circuit in which the transcription factor Rpn4 induces the proteasome genes and is rapidly degraded by the assembled proteasome. The integrity of t
Externí odkaz:
https://doaj.org/article/2fbaba380ec8457d80ef0a61f5fc5362
Autor:
Nader Sanai, Alex Sparreboom, Seongho Kim, Youming Xie, Norissa Honea, Xun Bao, Jianmei Wu, Jing Li
SUPPLEMENTARY METHODS Supplementary Figure 1 Overall metabolic kinetics of AZD1775 in human liver and intestinal microsomes (HLM and HIM). Supplementary Figure 2 PBPK model simulations showing the impact of BBB integrity (i.e., PSB), transporter acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a5461a360c2e21e96e77927d83d477
https://doi.org/10.1158/1078-0432.22463672.v1
https://doi.org/10.1158/1078-0432.22463672.v1
Autor:
Nader Sanai, Alex Sparreboom, Seongho Kim, Youming Xie, Norissa Honea, Xun Bao, Jianmei Wu, Jing Li
Purpose: AZD1775, a first-in-class, small-molecule inhibitor of the Wee1 tyrosine kinase, is under evaluation as a potential chemo- and radiosensitizer for treating glioblastoma. This study was to prospectively, quantitatively, and mechanistically in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91db8de060e413c222cbe773544c70ea
https://doi.org/10.1158/1078-0432.c.6525479
https://doi.org/10.1158/1078-0432.c.6525479
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 7/25/2023, Vol. 120 Issue 30, Following p1-10, 18p
Autor:
Jiliang Zhou, Donghong Ju, Kezhong Zhang, Fang Liu, Xiaohua Dai, Luyi Yu, Hong Jiang, Xiangqin He, Maozhou Yang, Leonard Lipovich, Qin Yin, Youming Xie, Jian Pu Zheng, Shuping Yin, Hui J. Li, Claire Li, Jiawei Zhao, Shichao Wu, Li Li
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
Yin Yang 1 (YY1) regulates gene transcription in a variety of biological processes. In this study, we aim to determine the role of YY1 in vascular smooth muscle cell (VSMC) phenotypic modulation both in vivo and in vitro. Here we show that vascular i
Autor:
Jianmei Wu, Jun Jiang, Seongho Kim, Sharon K. Michelhaugh, Jing Li, Xun Bao, Youming Xie, Nader Sanai, Sandeep Mittal
Publikováno v:
Clin Pharmacol Ther
The knowledge of transporter protein expression and function at the human blood-brain barrier (BBB) is critical to prediction of drug BBB penetration and design of strategies for improving drug brain/brain tumor delivery. This study determined absolu