Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Youmin Weng"'
Autor:
M. Maccoss, Paul E. Finke, Bruce L. Daugherty, Youmin Weng, Di Salvo J, Julie A. DeMartino, Christopher L. Lynch, Laurie A. Castonguay, Marty S. Springer, J. J. Hale, Sander G. Mills, Adolfsen W, Charles G. Caldwell, Ruth Kilburn
Publikováno v:
Biochemistry. 42:1544-1550
The results of investigations in these laboratories of 2-aryl-4-(piperidin-1-yl)butanamines and 1,3,4-trisubstituted pyrrolidines as human CCR5 antagonists have recently been disclosed. To facilitate further development of these antagonists, we have
Autor:
Barry R. Cunningham, Rose M. Cubbon, Peter T. Meinke, Richard T. Cummings, Nigel J. Liverton, Julie A. DeMartino, Robert A. Frankshun, Youmin Weng, Linda S. Wicker, Patricia M. Cameron, James E. Thompson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1219-1223
Jak3 is a protein tyrosine kinase that is associated with the shared gamma chain of receptors for cytokines IL2, IL4, IL7, IL9, and IL13. We have discovered that a pyridone-containing tetracycle (6) may be prepared from trisubstituted imidazole (5) i
Autor:
Salvatore J. Siciliano, Janet Lineberger, Julie A. DeMartino, Michael P. Kavanaugh, Renee Danzeisen, Martin S. Springer, Shawn E. Kuhmann, Michael D. Miller, Youmin Weng, Navid Madani, David Kabat
Publikováno v:
Journal of Biological Chemistry. 274:1905-1913
Like the CCR5 chemokine receptors of humans and rhesus macaques, the very homologous (approximately 98-99% identical) CCR5 of African green monkeys (AGMs) avidly binds beta-chemokines and functions as a coreceptor for simian immunodeficiency viruses.
Autor:
Mary Jo Staruch, Salvatore J. Siciliano, Martin S. Springer, Sandra L. Gould, Kristine E. Waldburger, Bruce L. Daugherty, Anna Sirotina-Meisher, Julie A. DeMartino, Youmin Weng
Publikováno v:
Journal of Biological Chemistry. 273:18288-18291
IP10 and MIG are two members of the CXC branch of the chemokine superfamily whose expression is dramatically up-regulated by interferon (IFN)-gamma. The proteins act largely on natural killer (NK)-cells and activated T-cells and have been implicated
Publikováno v:
Molecular and Cellular Biology. 16:5477-5490
mRNA degradation is an important control point in the regulation of gene expression and has been linked to the process of translation. One clear example of this linkage is the nonsense-mediated mRNA decay pathway, in which nonsense mutations in a gen
Autor:
Laurence B. Peterson, Min Lu, Julie A. DeMartino, Linda S. Wicker, Naomi Nomura, Shiow-Ling Chen, John S. Mudgett, Jerry Di Salvo, Greg E. Koch, Ray Rosa, Youmin Weng, Jenny Xie
Publikováno v:
Journal of leukocyte biology. 73(6)
Naïve T cells, when activated by specific antigen and cytokines, up-regulate adhesion molecules as well as chemokine receptors on their surface, which allows them to migrate to inflamed tissues. Human studies have shown that CXCR3 is one of the chem
Autor:
Ronald L. Rabin, Karen L. Elkins, Senkuta Gebeyehu, Hongwei H. Zhang, Matthew K. Park, Fang Liao, Joshua M. Farber, Doron Amichay, Akiko Iwasaki, Julie A. DeMartino, Youmin Weng, Elizabeth Wick, Alex Grinberg, Paul E. Love, Timothy Michael Wright
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 169(3)
Monokine induced by IFN-γ (Mig; CXC chemokine ligand 9) is an IFN-γ-inducible CXC chemokine that signals through the receptor CXCR3 and is known to function as a chemotactic factor for human T cells, particularly following T cell activation. The mi
Autor:
Kouetsu, Ogasawara, Shigeaki, Hida, Youmin, Weng, Akio, Saiura, Kojiro, Sato, Hiroshi, Takayanagi, Shinya, Sakaguchi, Taeko, Yokochi, Tatsuhiko, Kodama, Makoto, Naitoh, Julie A, De Martino, Tadatsugu, Taniguchi
Publikováno v:
Genes to cells : devoted to molecularcellular mechanisms. 7(3)
Activation of both CD4+ T and CD8+ T cells is triggered by the engagement of the T cell antigen receptor (TCR) with MHC/peptide complexes on antigen-presenting cells. This process also requires other molecular interactions, which transmit co-stimulat
Autor:
Haley A. Perlick, Harry C. Dietz, Stuart W. Peltz, Maria J. Ruiz-Echevarria, Xia Han, Youmin Weng, Michael D. Ter-Avanesyan, Sergey Paushkin, Kevin Czaplinski
The nonsense-mediated mRNA decay pathway is an example of an evolutionarily conserved surveillance pathway that rids the cell of transcripts that contain nonsense mutations. The product of theUPF1 gene is a necessary component of the putative surveil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ca7129666c66726a01afc34fb06a46
https://europepmc.org/articles/PMC316864/
https://europepmc.org/articles/PMC316864/
Autor:
Castonguay, Laurie A., Youmin Weng, Adolfsen, William, Di Salvo, Jerry, Kilburn, Ruth, Caldwell, Charles G., Daugherty, Bruce L., Finke, Paul E., Hale, Jeffrey J., Lynch, Christopher L., Mills, Sander G., MacCoss, Malcolm, Springer, Martin S., DeMartino, Julie A.
Publikováno v:
Biochemistry; 2/18/2003, Vol. 42 Issue 6, p1544, 7p, 4 Color Photographs, 4 Diagrams, 1 Chart, 2 Graphs