A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity.

Autor: Dusonchet J; Department of Pharmacology and Experimental Therapeutics and Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA, Howard Hughes Medical Institute, Department of Biomedical Engineering and Center of Synthetic Biology, Boston University, Boston, MA 02215, USA., Li H; Center for Individualized Medicine, Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA., Guillily M; Department of Pharmacology and Experimental Therapeutics and., Liu M; Laboratory for Drug Discovery in Neurodegeneration, Harvard NeuroDiscovery Center, Brigham and Women's Hospital, Cambridge, MA 02139, USA., Stafa K; Laboratory of Molecular Neurodegenerative Research, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland., Derada Troletti C; Department of Pharmacology and Experimental Therapeutics and., Boon JY; Department of Pharmacology and Experimental Therapeutics and., Saha S; Department of Pharmacology and Experimental Therapeutics and., Glauser L; Laboratory of Molecular Neurodegenerative Research, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland., Mamais A; Reta Lila Weston Institute of Neurological Studies, UCL, Institute of Neurology, London, WC1N 1PJ, UK., Citro A; Department of Pharmacology and Experimental Therapeutics and., Youmans KL; Department of Pharmacology and Experimental Therapeutics and., Liu L; Department of Pharmacology and Experimental Therapeutics and., Schneider BL; Neurodegenerative Studies Laboratory, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland., Aebischer P; Neurodegenerative Studies Laboratory, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland., Yue Z; Department of Neurology and Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Bandopadhyay R; Reta Lila Weston Institute of Neurological Studies, UCL, Institute of Neurology, London, WC1N 1PJ, UK., Glicksman MA; Laboratory for Drug Discovery in Neurodegeneration, Harvard NeuroDiscovery Center, Brigham and Women's Hospital, Cambridge, MA 02139, USA., Moore DJ; Laboratory of Molecular Neurodegenerative Research, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland., Collins JJ; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA, Howard Hughes Medical Institute, Department of Biomedical Engineering and Center of Synthetic Biology, Boston University, Boston, MA 02215, USA, bwolozin@bu.edu jcollins@bu.edu., Wolozin B; Department of Pharmacology and Experimental Therapeutics and Department of Neurology, Boston University School of Medicine, Boston, MA, 02118, USA, bwolozin@bu.edu jcollins@bu.edu.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2014 Sep 15; Vol. 23 (18), pp. 4887-905. Date of Electronic Publication: 2014 May 02.

Levels of soluble apolipoprotein E/amyloid-β (Aβ) complex are reduced and oligomeric Aβ increased with APOE4 and Alzheimer disease in a transgenic mouse model and human samples.

Autor: Tai LM; Department of Anatomy and Cell Biology, University of Illinois, Chicago, Illinois 60612, USA., Bilousova T, Jungbauer L, Roeske SK, Youmans KL, Yu C, Poon WW, Cornwell LB, Miller CA, Vinters HV, Van Eldik LJ, Fardo DW, Estus S, Bu G, Gylys KH, Ladu MJ

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2013 Feb 22; Vol. 288 (8), pp. 5914-26. Date of Electronic Publication: 2013 Jan 04.

TDP-43: a new player on the AD field?

Autor: Youmans KL; Dept. of Pharmacology, Boston University School of Medicine, USA., Wolozin B

Publikováno v: Experimental neurology [Exp Neurol] 2012 Sep; Vol. 237 (1), pp. 90-5. Date of Electronic Publication: 2012 Jun 04.

Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations.

Autor: Youmans KL; Dept of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, United States. kyouma2@uic.edu, Leung S, Zhang J, Maus E, Baysac K, Bu G, Vassar R, Yu C, LaDu MJ

Publikováno v: Journal of neuroscience methods [J Neurosci Methods] 2011 Mar 15; Vol. 196 (1), pp. 51-9. Date of Electronic Publication: 2011 Jan 08.

Proposed mechanism for lipoprotein remodelling in the brain.

Autor: Yu C; Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA., Youmans KL, LaDu MJ

Publikováno v: Biochimica et biophysica acta [Biochim Biophys Acta] 2010 Aug; Vol. 1801 (8), pp. 819-23. Date of Electronic Publication: 2010 May 12.