Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Youlong Fan"'
Autor:
Yuanyuan Zhao, Kang Duan, Youlong Fan, Shengrong Li, Liyan Huang, Zhengchao Tu, Hongyan Sun, Gregory M. Cook, Jing Yang, Pinghua Sun, Yi Tan, Ke Ding, Zhengqiu Li
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Covalent probes coupled with chemical proteomics represent a powerful method for investigating small molecule and protein interactions. However, the creation of a reactive warhead within various ligands to form covalent probes has been a maj
Externí odkaz:
https://doaj.org/article/091e321203564c82b8508be17562887f
Publikováno v:
Journal of Medicinal Chemistry. 66:2851-2864
Autor:
Guanghui Tang, Shao Q. Yao, Youlong Fan, Chengjun Zhu, Hongfei Si, Liang Zhong, Zhi-Min Zhang, Ke Ding, Zhibin Yin, Ping-Hua Sun, Hongyan Sun, Zhengqiu Li, Huilin Li, Zhang Zhang
Publikováno v:
Journal of Medicinal Chemistry. 64:15582-15592
The "inverse drug discovery" strategy is a potent means of exploring the cellular targets of latent electrophiles not typically used in medicinal chemistry. Cyclopropenone, a powerful electrophile, is generally used in bio-orthogonal reactions mediat
Autor:
Wen-Cai Ye, Zhi-Min Zhang, Youlong Fan, Jigang Wang, Hu Jun, Minhao Huang, Ke Ding, Zhengqiu Li, Xingfeng Yin, Nan Ma, Wenyan Liu
Publikováno v:
Journal of the American Chemical Society. 142:6051-6059
Protein modification by chemical reagents has played an essential role in the treatment of human diseases. However, the reagents currently used are limited to the covalent modification of cysteine and lysine residues. It is thus desirable to develop
Publikováno v:
Colloids and Surfaces B: Biointerfaces. 208:112053
Solution acidification exists under some physiological conditions (e.g. lysosomes in cells) and diseases (e.g. atherosclerosis, tumors, etc.). It is poorly understood whether and how acidification influences the size and biomechanical (stiffness and
Autor:
Youlong Fan, Hongfei Si, Zhang Zhang, Liang Zhong, Hongyan Sun, Chengjun Zhu, Zhibin Yin, Huilin Li, Guanghui Tang, Yao, Shao Q., Pinghua Sun, Zhi-Min Zhang, Ke Ding, Zhengqiu Li
Publikováno v:
Journal of Medicinal Chemistry; 11/11/2021, Vol. 64 Issue 21, p15582-15592, 11p