Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Youko Hirayama"'
Autor:
Mizuki Yamamoto, Jin Gohda, Ayako Kobayashi, Keiko Tomita, Youko Hirayama, Naohiko Koshikawa, Motoharu Seiki, Kentaro Semba, Tetsu Akiyama, Yasushi Kawaguchi, Jun-ichiro Inoue
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT The ongoing global vaccination program to prevent SARS-CoV-2 infection, the causative agent of COVID-19, has had significant success. However, recently, virus variants that can evade the immunity in a host achieved through vaccination have e
Externí odkaz:
https://doaj.org/article/79830b4f7f5f45f98ee50d504ba28a86
Autor:
Mizuki Yamamoto, Keiko Tomita, Youko Hirayama, Jun-ichiro Inoue, Yasushi Kawaguchi, Jin Gohda
The SARS-CoV-2 Omicron variant reportedly displays decreased usage of the cell surface entry pathway mediated by the host transmembrane protease, serine 2 (TMPRSS2) and increased usage of the endosomal entry pathway mediated by cathepsin B/L. These d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5770a02b49bff340b7ccd8c14f61d576
https://doi.org/10.1101/2022.03.21.485084
https://doi.org/10.1101/2022.03.21.485084
Autor:
Mizuki Yamamoto, Jin Gohda, Ayako Kobayashi, Keiko Tomita, Youko Hirayama, Naohiko Koshikawa, Motoharu Seiki, Kentaro Semba, Tetsu Akiyama, Yasushi Kawaguchi, Jun-ichiro Inoue
The ongoing global vaccination program to prevent SARS-CoV-2 infection, the causative agent of COVID-19, has had significant success. However, recently virus variants have emerged that can evade the immunity in a host achieved through vaccination. Co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78aa81a7eaca99187bd957f120f3fe7a
https://doi.org/10.1101/2021.12.14.472513
https://doi.org/10.1101/2021.12.14.472513
Autor:
Kazuhiko S.K. Uchida, Jennifer G. DeLuca, Kosuke Sako, Youko Hirayama, Abe Yusuke, Kentaro Takagaki, Toru Hirota, Jacob A. Herman
Publikováno v:
Developmental Cell. 36:487-497
Incorrect attachment of kinetochore microtubules is the leading cause of chromosome missegregation in cancers. The highly conserved chromosomal passenger complex (CPC), containing mitotic kinase Aurora B as a catalytic subunit, ensures faithful chrom
Autor:
Toru Hirota, Masaaki Oyama, Yutaka Aoyagi, Hiroko Kozuka-Hata, Youko Hirayama, Kota Nagasaka, Satoshi Abe, Chikashi Obuse
Publikováno v:
Genes & Development. 25:863-874
The cell cycle transition from interphase into mitosis is best characterized by the appearance of condensed chromosomes that become microscopically visible as thread-like structures in nuclei. Biochemically, launching the mitotic program requires the
Autor:
Izumi Matsumoto, Kazuo Okimoto, Takaki Seki, Okio Hino, Tadashi Inoue, Tadayoshi Ueda, Kazuyasu Kijima, Mami Kouchi, Youko Hirayama
Publikováno v:
Tumor Biology. 30:249-256
A germline insertion of a single nucleotide in the rat homologue of the human Birt-Hogg-Dubé (BHD) gene gives rise to dominantly inherited renal cell carcinoma (RCC) in the Nihon rat model. In this study, we established 7 lines (NR cell lines NR22,
Autor:
Kazuhiko S.K. Uchida, Kentaro Takagaki, Toru Hirota, Youko Hirayama, Kazuki Kumada, Tetsuo Noda
Publikováno v:
The Journal of Cell Biology
The spindle assembly checkpoint (SAC) monitors the attachment of microtubules to the kinetochore and inhibits anaphase when microtubule binding is incomplete. The SAC might also respond to tension; however, how cells can sense tension and whether its
Autor:
Hiroaki Mitani, Youko Hirayama, Hiroyuki Adachi, Toshiyuki Kobayashi, Kazunori Kajino, Shuichi Majima, Hiroaki Shiina, Okio Hino, Mikio Igawa, Shigeyuki Kon
Publikováno v:
Oncogene. 23:3495-3500
Functional inactivation of tuberous sclerosis 2 gene (Tsc2) leads to renal carcinogenesis in the hereditary renal carcinoma Eker rat models. Recent studies revealed a role of tuberin, a TSC2 product, in suppressing the p70 S6 kinase (p70S6K) activity
Publikováno v:
Proceedings of the Japan Academy, Series B. :22-25
Recent genetic studies of Drosophila melanogaster and subsequent biochemical analysis in mammalian cells revealed that products of tuberous sclerosis genes, TSC1 and TSC2, regulate insulin signaling via suppression of p70 ribosomal S6 subunit-kinase
Publikováno v:
International Journal of Cancer. 77:895-900
A number of cancer genes have been identified by the study of hereditary human cancers and shown to be involved in sporadic genesis of the same tumors. We have identified a germline mutation in the rat homologue of the human tuberous sclerosis (TSC2)