Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Youichirou, Matsuzaki"'
Autor:
Toshiyuki Sakai, Junko Takayasu, Akiyoshi Nishikawa, Toshiaki Hitomi, Hoyoku Nishino, Yusuke Okuyama, Youichirou Matsuzaki, Makoto Koyama, Masako Enoki-Konishi, Tomoya Yokota, Toshihiko Osawa, Mayumi Kawanaka
Publikováno v:
Cancer Science. 98:1447-1453
Sesamin is a major lignan constituent of sesame and possesses multiple functions such as antihypertensive, cholesterol-lowering, lipid-lowering and anticancer activities. Several groups have previously reported that sesamin induces growth inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1093d3772152f74737cd5bb80263258
https://doi.org/10.1111/j.1349-7006.2007.00560.x
https://doi.org/10.1111/j.1349-7006.2007.00560.x
Autor:
Youichirou Matsuzaki, Toshiyuki Sakai
Publikováno v:
Environmental Health and Preventive Medicine. 10:72-77
Inactivation of the p16(INK4a) gene is one of the most frequent defects that contribute to oncogenesis in human cancer, since it is a tumor-suppressor gene. Therefore, functional restoration of p16(INK4a) is one of the most effective methods for canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c05403528463ce1cc18db2a00364765
https://doi.org/10.1007/bf02897996
https://doi.org/10.1007/bf02897996
Publikováno v:
FEBS Letters. 554:347-350
Histone deacetylase (HDAC) inhibitors arrest human tumor cells at the G1 phase of the cell cycle and activate the cyclin-dependent kinase inhibitor, p21(WAF1/Cip1). However, several studies have suggested the existence of a p21(WAF1/Cip1)-independent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a09346861c2a74ffca1f8135b5d871ba
https://doi.org/10.1016/s0014-5793(03)01186-4
https://doi.org/10.1016/s0014-5793(03)01186-4
Autor:
Toshiaki Hitomi, Tomoya Yokota, Toshiyuki Sakai, Youichirou Matsuzaki, Akiyoshi Nishikawa, Makoto Koyama, Mayumi Kawanaka, Doris Germain
Publikováno v:
Oncology reports. 19(3)
Arctiin is a major lignan constituent of Arctium lappa and has anti-cancer properties in animal models. It was recently reported that arctiin induces growth inhibition in human prostate cancer PC-3 cells. However, the growth inhibitory mechanism of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a38cd5a7e30759a6a72086e4f39f1df5
https://pubmed.ncbi.nlm.nih.gov/18288407
https://pubmed.ncbi.nlm.nih.gov/18288407
Autor:
Kazuhide Hayakawa, Reina Kurachi, Yoshihiro Sowa, Takayuki Yoshida, Toshiyuki Sakai, Toyomichi Nanayama, Takayuki Yamaguchi, Takao Yamori, Yoshikazu Hori, Hiroyuki Abe, Shingo Yogosawa, Junya Kakegawa, Youichirou Matsuzaki, Koichi Takagi, Makoto Koyama, Nobuyuki Tajima
Publikováno v:
Cancer science. 98(11)
The INK4 family members p16(INK4a) and p15(INK4b) negatively regulate cell cycle progression by inhibition of cyclin-dependent kinase (CDK) 4/6. Loss of p16(INK4a) functional activity is frequently observed in tumor cells, and is thought to be one of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4af0edabe5edc0ae91505eca6ae0ba3d
https://pubmed.ncbi.nlm.nih.gov/17784872
https://pubmed.ncbi.nlm.nih.gov/17784872
Autor:
Toshiyuki Sakai, Toshiaki Hitomi, Mayumi Kawanaka, Shingo Yogosawa, Youichirou Matsuzaki, Makoto Koyama
Publikováno v:
Molecular cancer therapeutics. 6(5)
Inactivation of the retinoblastoma protein pathway is the most common abnormality in malignant tumors. We therefore tried to detect agents that induce the cyclin-dependent kinase inhibitor p15INK4b and found that ZD1839 (gefitinib, Iressa) could up-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f21691b395f45f56b9ecb4e66a07c46a
https://pubmed.ncbi.nlm.nih.gov/17513607
https://pubmed.ncbi.nlm.nih.gov/17513607
Autor:
Toshiaki Hitomi, Toshiyuki Sakai, Makoto Koyama, Youichirou Matsuzaki, Mayumi Kawanaka, Yuuki Takaoka
Publikováno v:
International Journal of Oncology.
15-deoxy-Delta12, 14-prostaglandin J2 (15-d-PGJ2) inhibits cellular proliferation primarily in the G1 phase of the cell cycle. However, the molecular mechanism responsible for this effect has not been sufficiently elucidated. Here, we show that the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36896f4f80327f9cde733ca7a61a7988
https://doi.org/10.3892/ijo.27.2.497
https://doi.org/10.3892/ijo.27.2.497
Autor:
Youichirou, Matsuzaki, Makoto, Koyama, Toshiaki, Hitomi, Yuuki, Takaoka, Mayumi, Kawanaka, Toshiyuki, Sakai
Publikováno v:
International journal of oncology. 27(2)
15-deoxy-Delta12, 14-prostaglandin J2 (15-d-PGJ2) inhibits cellular proliferation primarily in the G1 phase of the cell cycle. However, the molecular mechanism responsible for this effect has not been sufficiently elucidated. Here, we show that the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6446da9e70946113c4ad00632454d088
https://pubmed.ncbi.nlm.nih.gov/16010433
https://pubmed.ncbi.nlm.nih.gov/16010433
Publikováno v:
Oncogene. 23(31)
p18(INK4c), a member of INK4 family of cyclin-dependent kinase inhibitors, negatively regulates the cyclin D-cyclin-dependent kinase 4/6 complexes which promote G1/S transition by phosphorylating the retinoblastoma tumor-suppressor gene product. Seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0714596699d3cb3c94fc311de96992b4
https://pubmed.ncbi.nlm.nih.gov/15107819
https://pubmed.ncbi.nlm.nih.gov/15107819
Autor:
Martine F. Roussel, Toshiyuki Sakai, Tomoya Yokota, Frederique Zindy, Kazuhiro Miyazawa, Youichirou Matsuzaki
Publikováno v:
Oncogene. 23(31)
Histone deacetylase (HDAC) inhibitors are known to arrest human tumor cells at the G1 phase of the cell cycle and activate the cyclin-dependent kinase inhibitor, p21(WAF1/Cip1). However, several studies have suggested the existence of a p21(WAF1/Cip1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61046cd81c9ee4dc4d6f4e6c41ac2e49
https://pubmed.ncbi.nlm.nih.gov/15107822
https://pubmed.ncbi.nlm.nih.gov/15107822