Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Youichi Tajima"'
Autor:
Tamas Nemeth, Naoko Yoshizawa-Sugata, Agnes Pallier, Youichi Tajima, Yue Ma, Éva Tóth, Hisao Masai, Yoko Yamakoshi
Publikováno v:
Chemical & Biomedical Imaging, Vol 1, Iss 2, Pp 157-167 (2023)
With the aim of developing more stable Gd(III)–porphyrin complexes, two types of ligands 1 and 2 with carboxylic acid anchors were synthesized. Due to the N-substituted pyridyl cation attached to the porphyrin core, these porphyrin ligands were h
Externí odkaz:
https://doaj.org/article/b687f69bb95f41b6957bf4209229513e
Autor:
Daichi Sadato, Tomio Ono, Saki Gotoh‐Saito, Naoki Kajiwara, Namiko Nomura, Masako Ukaji, Liying Yang, Kenji Sakimura, Youichi Tajima, Keisuke Oboki, Futoshi Shibasaki
Publikováno v:
FEBS Open Bio, Vol 8, Iss 8, Pp 1188-1201 (2018)
Mammalian eukaryotic translation initiation factor 3 (eIF3) is the largest complex of the translation initiation factors. The eIF3 complex is comprised of thirteen subunits, which are named eIF3a to eIF3 m in most multicellular organisms. The eIF3e g
Externí odkaz:
https://doaj.org/article/eb4923fdb32642dc9dd2c87a760c5894
MSCs (mesenchymal stem cells), responsible for tissue repair, rarely undergo cell fusion with somatic cells. Here, we show that approximately 5% of bladder cancer cells (UMUC-3) fuses with bone marrow-derived MSC (BM-MSC) in co-culture and exhibits i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef3ed3f3be54224669c4d919ad275f00
https://doi.org/10.1101/2022.06.14.496068
https://doi.org/10.1101/2022.06.14.496068
Autor:
Saki Gotoh-Saito, Tomio Ono, Namiko Nomura, Youichi Tajima, Futoshi Shibasaki, Keisuke Oboki, Naoki Kajiwara, Masako Ukaji, Liying Yang, Kenji Sakimura, Daichi Sadato
Publikováno v:
FEBS Open Bio
Mammalian eukaryotic translation initiation factor 3 (eIF3) is the largest complex of the translation initiation factors. The eIF3 complex is comprised of thirteen subunits, which are named eIF3a to eIF3 m in most multicellular organisms. The eIF3e g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::261efe3750f8b6cdfa5c3a68854d105e
http://europepmc.org/articles/PMC6070656
http://europepmc.org/articles/PMC6070656
Autor:
Hitoshi Sakuraba, Youichi Tajima, Chikako Tasaki, Keisuke Kitakaze, Daisuke Tsuji, Takatsugu Hirokawa, Kohji Itoh
Publikováno v:
Biochemistry and Biophysics Reports
GM2 gangliosidoses are autosomal recessive lysosomal storage diseases (LSDs) caused by mutations in the HEXA, HEXB and GM2A genes, which encode the human lysosomal β-hexosaminidase (Hex) α- and β-subunits, and GM2 activator protein (GM2A), respect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95bd1c68f671c3365d83d2113ee44d6e
Autor:
Youichi Tajima, Seiji Saito, Kunihiko Iwamoto, Kazuki Ohno, Hitoshi Sakuraba, Kohji Itoh, Takahiro Tsukimura, Toshihide Kobayashi, Ikuo Kawashima, Kanako Sugawara
Publikováno v:
Molecular Genetics and Metabolism. 96:233-238
Enzyme enhancement therapy (EET) for Fabry disease involving imino sugars has been developed and attracted interest. It is thought that imino sugars act as pharmacological chaperones for wild-type and mutant alpha-galactosidases (GLAs) in cells, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd50efbf35193817205baf1c388e19c
https://doi.org/10.1016/j.ymgme.2008.12.017
https://doi.org/10.1016/j.ymgme.2008.12.017
Autor:
Arnold J. J. Reuser, Kazuki Ohno, Seiji Saito, Masakazu Sekijima, Youichi Tajima, Kanako Sugawara, Hitoshi Sakuraba, Marian A. Kroos
Publikováno v:
Journal of Human Genetics, 54(6), 324-330. Nature Publishing Group
To elucidate the mechanism underlying transport and processing defects from the viewpoint of enzyme folding, we constructed three-dimensional models of human acid a-glucosidase encompassing 27 relevant amino acid substitutions by means of homology mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc24f444a7f6f6631545094914024c4
https://hdl.handle.net/1765/24557
https://hdl.handle.net/1765/24557
Autor:
Akemi Nishimoto, Zhongpeng Lu, Kazuhiro Kobayashi, Youichi Tajima, Fan Wang, Motoi Kanagawa, Fumi Tashiro, Shin'ichi Takeda, Nobuhiro Fujikake, Kevin P. Campbell, Tatsushi Toda, Yuko Miyagoe-Suzuki, Mariko Taniguchi, Yoshitaka Nagai, Tomohiro Chiyonobu, Tamao Endo, Jun-ichi Miyazaki, Masaji Tachikawa, Satoshi Takeda
Publikováno v:
Human Molecular Genetics
Hypoglycosylation and reduced laminin-binding activity of alpha-dystroglycan are common characteristics of dystroglycanopathy, which is a group of congenital and limb-girdle muscular dystrophies. Fukuyama-type congenital muscular dystrophy (FCMD), ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95bc4ca73c2e8620dacb3840dadf7e4c
https://doi.org/10.1093/hmg/ddn387
https://doi.org/10.1093/hmg/ddn387
Autor:
Tim Edmunds, Naho Ohyanagi, Kohji Itoh, Kaori Fujishima, Kobayashi Toshihide, Tadayasu Togawa, Daisuke Tsuji, Masahiko Ikekita, Kanako Sugawara, Ikuo Kawashima, Michiru Yoshimizu, Youichi Tajima, Sei-ichi Aikawa, Fumiko Matsuzawa, Kunihiko Iwamoto, Toshihiro Suzuki, Hitoshi Sakuraba, Kazuki Ohno
Publikováno v:
Clinica Chimica Acta. 391:68-73
Background Recently, enzyme enhancement therapy (EET) for Pompe disease involving imino sugars, which act as potential inhibitors of acid α-glucosidases in vitro , to improve the stability and/or transportation of mutant acid α-glucosidases in cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2293f690368010fe83c4ecfdf0f3f5c
https://doi.org/10.1016/j.cca.2008.02.014
https://doi.org/10.1016/j.cca.2008.02.014
Autor:
Tomoko Fukushige, Ikuo Kawashima, Youichi Tajima, Toshihiro Suzuki, Kanako Sugawara, Hitoshi Sakuraba, Tamotsu Kanzaki, Takuro Kanekura, Tadayasu Togawa, Masahiko Ikekita, Takahiro Tsukimura
Publikováno v:
Biological and Pharmaceutical Bulletin. 31:1691-1695
To examine the uptake of a recombinant human alpha-L-iduronidase (laronidase) by cultured fibroblasts from a patient with mucopolysaccharidosis I (MPS I) and its effect on the cleavage of accumulated substrates, we performed enzymological, Western bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a9b87f6a15ec38c1174735880f0bf2
https://doi.org/10.1248/bpb.31.1691
https://doi.org/10.1248/bpb.31.1691