Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Youichi Shinozaki"'
Autor:
Eiji Shigetomi, Hideaki Suzuki, Yukiho J. Hirayama, Fumikazu Sano, Yuki Nagai, Kohei Yoshihara, Keisuke Koga, Toru Tateoka, Hideyuki Yoshioka, Youichi Shinozaki, Hiroyuki Kinouchi, Kenji F. Tanaka, Haruhiko Bito, Makoto Tsuda, Schuichi Koizumi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Reactive astrocytes play a pivotal role in the pathogenesis of neurological diseases; however, their functional phenotype and the downstream molecules by which they modify disease pathogenesis remain unclear. Here, we genetically increase P2
Externí odkaz:
https://doaj.org/article/2557cf6cc7f6489ba3fc0d968dc92110
Autor:
Akiko Sotozono, Kazuhiko Namekata, Xiaoli Guo, Youichi Shinozaki, Chikako Harada, Takahiko Noro, Tadashi Nakano, Takayuki Harada
Publikováno v:
Biochemistry and Biophysics Reports, Vol 39, Iss , Pp 101799- (2024)
Neurodegenerative diseases including glaucoma affect insulin signaling, and insulin treatment has been shown to reverse the neurodegenerative loss of dendritic complexity in retinal ganglion cells. Therefore, strategies for enhancing or maintaining i
Externí odkaz:
https://doaj.org/article/662727a36de84d238f5de1746015322c
Autor:
Youichi Shinozaki
Publikováno v:
Frontiers in Ophthalmology, Vol 4 (2024)
Externí odkaz:
https://doaj.org/article/3a8c239c4c3f4cfe954509a635544a8d
Publikováno v:
Frontiers in Ophthalmology, Vol 3 (2024)
Glial cells, a type of non-neuronal cell found in the central nervous system (CNS), play a critical role in maintaining homeostasis and regulating CNS functions. Recent advancements in technology have paved the way for new therapeutic strategies in t
Externí odkaz:
https://doaj.org/article/af970234dfef4ba4a119338b939a20dc
Autor:
Kazuhiko Namekata, Naoki Tsuji, Xiaoli Guo, Euido Nishijima, Sari Honda, Yuta Kitamura, Atsushi Yamasaki, Masamichi Kishida, Jun Takeyama, Hirokazu Ishikawa, Youichi Shinozaki, Atsuko Kimura, Chikako Harada, Takayuki Harada
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-8 (2023)
Abstract Dedicator of cytokinesis 3 (DOCK3) is an atypical member of the guanine nucleotide exchange factors (GEFs) and plays important roles in neurite outgrowth. DOCK3 forms a complex with Engulfment and cell motility protein 1 (Elmo1) and effectiv
Externí odkaz:
https://doaj.org/article/2c0459c1ded845d2905aa9f9482ad0c3
Autor:
Youichi Shinozaki, Schuichi Koizumi
Publikováno v:
Journal of Pharmacological Sciences, Vol 145, Iss 3, Pp 262-267 (2021)
Glaucoma, a progressive optic neuropathy and the leading cause of blindness, is characterized by impairment or degeneration of retinal ganglion cells (RGCs), which transmit visual information to the brain. Currently, 70 million people worldwide are a
Externí odkaz:
https://doaj.org/article/8b8303a16e8e43d281a4e134082da426
Autor:
Fumikazu Sano, Eiji Shigetomi, Youichi Shinozaki, Haruka Tsuzukiyama, Kozo Saito, Katsuhiko Mikoshiba, Hiroshi Horiuchi, Dennis Lawrence Cheung, Junichi Nabekura, Kanji Sugita, Masao Aihara, Schuichi Koizumi
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
Extensive activation of glial cells during a latent period has been well documented in various animal models of epilepsy. However, it remains unclear whether activated glial cells contribute to epileptogenesis, i.e., the chronically persistent proces
Externí odkaz:
https://doaj.org/article/a915495c6e1f433aba8681799e7b07bc
Autor:
Manao Kinoshita, Yuri Hirayama, Kayoko Fujishita, Keisuke Shibata, Youichi Shinozaki, Eiji Shigetomi, Akiko Takeda, Ha Pham Ngoc Le, Hideaki Hayashi, Miki Hiasa, Yoshinori Moriyama, Kazuhiro Ikenaka, Kenji F. Tanaka, Schuichi Koizumi
Publikováno v:
EBioMedicine, Vol 32, Iss , Pp 72-83 (2018)
Although psychotropic drugs act on neurons and glial cells, how glia respond, and whether glial responses are involved in therapeutic effects are poorly understood. Here, we show that fluoxetine (FLX), an anti-depressant, mediates its anti-depressive
Externí odkaz:
https://doaj.org/article/0994b8524db94945898522171ad5a080
Autor:
Mitsuhiko Katoh, Bao Wu, Huy Bang Nguyen, Truc Quynh Thai, Ryo Yamasaki, Haiyan Lu, Anna M. Rietsch, Musab M. Zorlu, Youichi Shinozaki, Yurika Saitoh, Sei Saitoh, Takashi Sakoh, Kazuhiro Ikenaka, Schuichi Koizumi, Richard M. Ransohoff, Nobuhiko Ohno
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Microglia are the resident macrophages of the central nervous system and play complex roles in the milieu of diseases including the primary diseases of myelin. Although mitochondria are critical for cellular functions and survival in the ner
Externí odkaz:
https://doaj.org/article/52abb5ec19ee44a2bc3a37aaeb839825
Autor:
Youichi Shinozaki, Keisuke Shibata, Keitaro Yoshida, Eiji Shigetomi, Christian Gachet, Kazuhiro Ikenaka, Kenji F. Tanaka, Schuichi Koizumi
Publikováno v:
Cell Reports, Vol 19, Iss 6, Pp 1151-1164 (2017)
Microglia and astrocytes become reactive following traumatic brain injury (TBI). However, the coordination of this reactivity and its relation to pathophysiology are unclear. Here, we show that microglia transform astrocytes into a neuroprotective ph
Externí odkaz:
https://doaj.org/article/7887800b970d4006874b04452b89b1d0