Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Youichi Nunokawa"'
Publikováno v:
FEBS Letters. 578:36-40
Nuclear factor kappa B (NF-kappaB) plays a wide variety of pathophysiological roles and modulation of its pathway can be a good novel drug target. Here, we found that our recently synthesized NF-kappaB inhibitor attenuated an ovalbumin-specific delay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306e7f072122aab9a99d21bff4b5c5bc
https://doi.org/10.1016/j.febslet.2004.10.065
https://doi.org/10.1016/j.febslet.2004.10.065
Autor:
Tadashi Miyamoto, Myung-Woo Hwang, Koh Ono, Ryosuke Nishio, Akira Yamaki, Masatake Hara, Kanjo Yamamoto, Youichi Nunokawa, Katsura Kitaura-Inenaga, Akira Matsumori
Publikováno v:
European Journal of Heart Failure. 6:137-144
Background: Nuclear factor kappa B (NF-κB) is activated by several factors, which increase the inflammatory response, and this activation, in turn, leads to the expression of several genes such as cytokines, and may play an important role in cardiov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d5e5fb2ee7aeac122b4e854b930d4a
https://doi.org/10.1016/j.ejheart.2003.10.007
https://doi.org/10.1016/j.ejheart.2003.10.007
Publikováno v:
Life Sciences. 67:2655-2661
This study was performed to examine the effects of the calcium channel blockers, nifedipine, amlodipine, diltiazem, and verapamil on the activation of the transcription factor NF-kappaB. A549 cells, a human epithelium-like lung carcinoma cell line, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca7861079444c470722e93b17e68011
https://doi.org/10.1016/s0024-3205(00)00849-3
https://doi.org/10.1016/s0024-3205(00)00849-3
Publikováno v:
Life Sciences. 67:2513-2519
Pimobendan, an inhibitor of phosphodiesterase III with calcium sensitizing properties, inhibits the production of cytokines and nitric oxide. In the present study, the effects of pimobendan and other inotropic agents on the activation of transcriptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f16096b1841e7e4133d057b0d74b12e
https://doi.org/10.1016/s0024-3205(00)00834-1
https://doi.org/10.1016/s0024-3205(00)00834-1
Publikováno v:
Biochemical and Biophysical Research Communications. 233:523-526
One of the mechanisms underlying the induction of human inducible nitric oxide synthase (hiNOS) by cytokines is transcriptional regulation. However, previous reports suggest that in human cells, the cytokine activation of the hiNOS expression is acco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82b3d0100a4bdc05294f9f493a82731
https://doi.org/10.1006/bbrc.1997.6471
https://doi.org/10.1006/bbrc.1997.6471
Publikováno v:
Archives of Biochemistry and Biophysics. 298:726-730
(6 R )-5,6,7,8-Tetrahydro- l -biopterin (R-THBP) is a cofactor not only for aromatic amino acid hydroxylases in mammalian tissues but also for nitric oxide synthase (NOS) induced by endotoxins or cytokines in some kinds of cells. Recently it has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9732f6f8238ee6c142502dc7bd5d96ed
https://doi.org/10.1016/0003-9861(92)90472-9
https://doi.org/10.1016/0003-9861(92)90472-9
Publikováno v:
Blood. 94(8)
We examined the expression of messenger RNA (mRNA) of the human inducible nitric oxide synthase (hiNOS) gene in a panel of human T-cell lines. Reverse transcriptase-polymerase chain reaction showed that human T-cell leukemia virus type-I (HTLV-I)-inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c8f296cec7c51419bd33560475806d
https://pubmed.ncbi.nlm.nih.gov/10515890
https://pubmed.ncbi.nlm.nih.gov/10515890
Publikováno v:
Biochemical and biophysical research communications. 223(2)
We previously showed a sequence of the 5'-flanking region of the human inducible nitric oxide synthase (hiNOS) gene that included putative cis-acting elements. A reported plasmid containing the 5'-flanking region of the hiNOS gene upstream from its r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ff783df17aa549080c77accc16e4da2
https://pubmed.ncbi.nlm.nih.gov/8670285
https://pubmed.ncbi.nlm.nih.gov/8670285
Autor:
Youichi Nunokawa, Shoji Tanaka
Publikováno v:
Biochemical and biophysical research communications. 188(1)
Interferon (IFN)-gamma inhibited the proliferation of rat vascular smooth muscle cells (VSMC) and increased the cyclic GMP (cGMP) concentration in the cells. The dose dependencies of the two effects were similar (IC50 = 4 U/ml for the anti-proliferat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9848b2fc9ada5b8b8a25d59249d5b5ad
https://pubmed.ncbi.nlm.nih.gov/1384487
https://pubmed.ncbi.nlm.nih.gov/1384487
Publikováno v:
Journal of Cardiac Failure. 9:S67
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10cccd80026232f76ac0b0a6e82d4b05
https://doi.org/10.1016/s1071-9164(03)00558-x
https://doi.org/10.1016/s1071-9164(03)00558-x