Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Youichi Miyamae"'
Autor:
Hitoshi Naraoka, Kenichiro Takeuchi, Sana Ota, Takeji Ohata, Jiro Seki, Kenichi Suzumura, Tomoyoshi Soga, Masashi Honma, Youichi Miyamae, Maki Ohishi
Publikováno v:
Journal of Proteome Research. 12:1399-1407
Nonsteroid anti-inflammatory drugs (NSAIDs) are among the most frequently prescribed drugs currently available. The most frequently reported serious side effects associated with NSAIDs are gastric mucosal ulceration and gastric hemorrhage. Presently,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13cd6acb4939344bffe32110506d8731
https://doi.org/10.1021/pr3010452
https://doi.org/10.1021/pr3010452
Publikováno v:
Environmental Mutagen Research. 27:145-151
Optimized conditions for an in vitro micronucleus (MN) test procedure were defined using a chamber slide that enabled the preparation of fine specimens without undergoing complicating procedures using culture dishes. The issues investigated are 1) th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc2aef0075981e7d26ef6992a13dd08b
https://doi.org/10.3123/jems.27.145
https://doi.org/10.3123/jems.27.145
Autor:
Kumiko Ishida, Shuji Tsuda, Youichi Miyamae, Kaoru Sekihashi, Naonori Matsusaka, Yu F. Sasaki, Hiroo Madarame, Mana Satoh
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 467:83-98
The genotoxicity of 22 mono-functional alkylating agents (including 9 dialkyl N-nitrosoamines) and 10 DNA crosslinkers selected from IARC (International Agency for Research on Cancer) groups 1, 2A, and 2B was evaluated in eight mouse organs with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8163d4c01e904b3fa66667ad27870cbe
https://doi.org/10.1016/s1383-5718(00)00014-0
https://doi.org/10.1016/s1383-5718(00)00014-0
Autor:
Kayoko Shimoi, Yu F. Sasaki, Hiroshi Kobayashi, Miyuki Igarashi-Soga, Makoto Hayashi, Mika Yamamoto, Youichi Miyamae
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 418:131-140
We evaluated a tissue homogenization technique that isolates nuclei for use in the in vivo comet assay. Five laboratories independently tested the technique using the liver, kidney, lung, spleen, and bone marrow of untreated and mutagen-treated male
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a943c9a89a41568b258da2b118ab872d
https://doi.org/10.1016/s1383-5718(98)00112-0
https://doi.org/10.1016/s1383-5718(98)00112-0
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 415:229-235
We evaluated the relationship between the onset of DNA damage and the characteristics of 5 model chemical mutagens with the single-cell gel electrophoresis (SCG) assay using L5178Y mouse lymphoma cells. We treated the cells with each chemical for 3 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd9c7b3311f99a9d4fc878bb12c7e21
https://doi.org/10.1016/s1383-5718(97)00192-7
https://doi.org/10.1016/s1383-5718(97)00192-7
Autor:
Takumi Awogi, Akihiro Wakata, Takayoshi Suzuki, Takeshi Morita, Koji Kondo, Makoto Hayashi, Norihide Asano, Youichi Miyamae, Sei-ichi Sato
Publikováno v:
Environmental and Molecular Mutagenesis. 32:84-100
The mouse has traditionally been used for the micronucleus test, with bone marrow the usual target organ. The aim of the 9th collaborative study by CSGMT was to evaluate the suitability of the rat for the micronucleus test, with bone marrow and perip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8f515c0d443a3ad13160eb4e872161a
https://doi.org/10.1002/(sici)1098-2280(1998)32:1<84::aid-em10>3.0.co
https://doi.org/10.1002/(sici)1098-2280(1998)32:1<84::aid-em10>3.0.co
Autor:
Youichi Miyamae, Yu F. Sasaki, Kouichi Iwasaki, Shuji Tsuda, Naohide Kinae, Michiko Murakami, Makiko Tanaka
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 393:107-113
The alkaline condition is an important factor for the alkaline single-cell gel electrophoresis (SCG) assay to detect the genotoxic effects of chemicals. In order to understand the relationship between DNA migration and alkaline condition, the effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4b4d84e944583ed9788b2accf8ab3e1
https://doi.org/10.1016/s1383-5718(97)00091-0
https://doi.org/10.1016/s1383-5718(97)00091-0
Autor:
Kazuyo Zaizen, Atsushi Miyamoto, Osamu Hirai, Miyuki Takashima, Yasuhiro Mine, Youichi Miyamae, Yuko Hattori
Publikováno v:
Mutation Research Letters. 324:43-50
The genotoxic activity of a new antitumor agent, FK973, was compared with that of mitomycin C (MMC) in eukaryotic and prokaryotic cells. In chromosome aberration tests using Chinese hamster fibroblast Don cells, FK973 induced a dose-related increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3f1706a4b064b9dd7bfdf1a61c3170
https://doi.org/10.1016/0165-7992(94)90066-3
https://doi.org/10.1016/0165-7992(94)90066-3
Autor:
Youichi Miyamae, Yasuhiro Mine, Yuko Hattori, Kazuyo Zaizen, Kaname Ohara, Astushi Miyamoto, Miyuki Takashima, Osamu Hirai
Publikováno v:
The Journal of Toxicological Sciences. 19:89-96
The genotoxicity of polyoxyethylene hydrogenated castor oil 60 (HCO-60) was examined in reverse mutation test in bacteria, chromosome aberration test in vitro and micronucleus test in mice. The in vitro tests were done with and without metabolic acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f63fd63cc5fc9014d4dd9d9bdf24b8
https://doi.org/10.2131/jts.19.2_89
https://doi.org/10.2131/jts.19.2_89
Autor:
Hiroyuki Izumi, Youichi Miyamae, Hideyo Noguchi, Yasuhiro Fujino, Atsushi Miyamoto, Osamu Hirai
Publikováno v:
Mutation research. 264(3)
It has been reported that the sensitivity of the in vivo mouse bone marrow micronucleus test can be increased by inducing erythropoiesis with exogenous erythropoietin prior to treatment (Suzuki et al., 1989). In these studies we demonstrate that remo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d28ce4c419b6e8079ec83ee71f8388
https://pubmed.ncbi.nlm.nih.gov/1944391
https://pubmed.ncbi.nlm.nih.gov/1944391