Výsledky vyhledávání - "Youichi Iimura"

Effect of cupula shrinkage on the semicircular canal activity

Autor: Shigetaka Shimizu, Ujimoto Konomi, Youichi Iimura, Taro Inagaki, Koji Otsuka, Mamoru Suzuki

Publikováno v: Acta Oto-Laryngologica. 130:1092-1096

Conclusion: With half-sized cupula, the semicircular canal nerve potentials decreased under slow stimulus, thus potentially leading to reduced caloric response. This also suggests that shrunken cupula may cause dizziness because of its hypermobility.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dbc06fb7e7207e221447a89fb17d692
https://doi.org/10.3109/00016481003677456

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Metastasis of Renal Cell Carcinoma to the Paranasal Sinuses

Autor: Rei Motohashi, Susumu Araki, Shoko Nemoto, Noriko Nagai, Mamoru Suzuki, Youichi Iimura

Publikováno v: Practica Oto-Rhino-Laryngologica. 101:777-780

Renal cell carcinoma tends to present multiple hematogenous metastases. But metastasis to the paranasal sinuses is rare. We encountered metastasis of renal cell carcinoma to the ethmoidal and sphenoidal sinuses. Because of extensive lesion, we select

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::afdd0ffd865e1d2f08c5fee2de5e151d
https://doi.org/10.5631/jibirin.101.777

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Clinical Observation of Middle Ear Surgery in the Elderly

Autor: Atsushi Kawano, Kumiko Yukawa, Taro Yamaguchi, Mamoru Suzuki, Youichi Iimura, Hiroyuki Fujita

Publikováno v: Practica Oto-Rhino-Laryngologica. 97:1067-1070

We performed surgery of the middle ear in 157 patients (171 ears) between April 1997 and March 2001. In this study, the clinical features and outcomes of middle ear surgery performed in 11 patients (13 ears) 70 or more years of age were analyzed. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07765100f083e9a4d243d6c6e898ed2c
https://doi.org/10.5631/jibirin.97.1067

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Research and Development of Donepezil Hydrochloride, a New Type of Acetylcholinesterase Inhibitor

Autor: Yoshiharu Yamanishi, Hiroo Ogura, Youichi Iimura, Yasuo Arai, Hachiro Sugimoto

Publikováno v: Japanese Journal of Pharmacology. 89:7-20

A wide range of evidence shows that cholinesterase (ChE) inhibitors can interfere with the progression of Alzheimer's disease (AD). The earliest known ChE inhibitors, namely, physostigmine and tacrine, showed modest improvement in the cognitive funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a10258ffb3bc3cccec1e972ee981c024
https://doi.org/10.1254/jjp.89.7

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Donepezil Hydrochloride (E2020) and Other Acetylcholinesterase Inhibitors

Autor: Youichi Iimura, Yoshiyuki Kawakami, Yoshiharu Yamanishi, Hachiro Sugimoto

Publikováno v: Current Medicinal Chemistry. 7:303-339

A wide range of evidence shows that acetylcholinesterase (AChE) inhibitors can interfere with the progression of Alzheimer's disease (AD). The successful development of these compounds was based on a well-accepted theory that the decline in cognitive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005082e6b361e780dd70213d0d98c063
https://doi.org/10.2174/0929867003375191

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The Simulated Binding of (±)-2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4- piperidinyl]methyl]-1H-inden-1-one Hydrochloride (E2020) and Related Inhibitors to Free and Acylated Acetylcholinesterases and Corresponding Structure−Activity Analyses

Autor: Yoshiyuki Kawakami, Atsushi Inoue, Misako Wakita, Youichi Iimura, Takatoshi Kawai, Hachiro Sugimoto

Publikováno v: Journal of Medicinal Chemistry. 39:4460-4470

The simulated binding profiles of acetylcholine, ACh, and the inhibitor (+/-)-2,3-dihydro-5,6- dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-on e hydrochloride (E2020), 1, and some of its analogs to acetylcholinesterase, AChE, were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecccfe24f84e773e1a86f36135802c2e
https://doi.org/10.1021/jm950596e

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Synthesis and Structure-Activity Relationships of Acetylcholinesterase Inhibitors: 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine Hydrochloride and Related Compounds

Autor: Kiyomi Yamatsu, Hachiro Sugimoto, Yoshiharu Yamanishi, Youichi Iimura

Publikováno v: Journal of Medicinal Chemistry. 38:4821-4829

Following the discovery of a new series of anti-acetylcholinesterase (anti-AChE) inhibitors such as 1-benzyl-4-[2-(N-benzoylamino)ethyl]piperidine (1), we reported that its rigid analogue, 1-benzyl-4-(2-isoindolin-2-ylethyl)piperidine (5), had more p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386b39ae9fb1d21565a09d4fc1682dc1
https://doi.org/10.1021/jm00024a009

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ChemInform Abstract: Synthesis and Structure-Activity Relationships of Acetylcholinesterase Inhibitors: 1-Benzyl-4-((5,6-dimethoxy-1-oxoindan-2-yl)methyl) piperidine Hydrochloride and Related Compounds

Autor: Kiyomi Yamatsu, Hachiro Sugimoto, Yoshiharu Yamanishi, Youichi Iimura

Publikováno v: ChemInform. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba51bc6d3a08e53dd80e6e0da4209d8d
https://doi.org/10.1002/chin.199614152

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