Zobrazeno 1 - 10
of 223
pro vyhledávání: '"Youichi ABE"'
Autor:
Akira Nishiyama, Youichi Abe
Publikováno v:
Journal of Pharmacological Sciences, Vol 100, Iss 1, Pp 9-16 (2006)
Abstract.: Recent clinical and pre-clinical studies have indicated the utility of mineralocorticoid receptor (MR) antagonists in renal injury. We have demonstrated in rats that chronic treatment with aldosterone results in severe proteinuria and rena
Externí odkaz:
https://doaj.org/article/cbbf274ee877406687796c114c3a5089
Publikováno v:
Journal of Pharmacological Sciences, Vol 96, Iss 4, Pp 406-410 (2004)
The candidate mechanisms for maintaining hypertension in a chronically angiotensin II (Ang II)-infused state include direct vasoconstriction of the vasculature, disturbance of renal water/sodium handling, and central/peripheral sympathetic nerve regu
Externí odkaz:
https://doaj.org/article/1ea7eaddd2e04b4491c3e54b58ffb0bc
Publikováno v:
International Journal of Pharmaceutics. 375:55-60
Brain pharmacokinetic behaviors of tetramethylpyrazine (TMP) following intranasal (i.n.) and intravenous (i.v.) administration, have been investigated using brain microdialysis technique in free-moving rats. A cross-over design was employed in the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8d917ec69fe1a188c4d5196a3838cd
https://doi.org/10.1016/j.ijpharm.2009.03.034
https://doi.org/10.1016/j.ijpharm.2009.03.034
Autor:
Akira Nishiyama, Guo-Xing Zhang, Yoshihide Fujisawa, Shoji Kimura, Youichi Abe, Yukiko Nagai, Koji Ohmori
Publikováno v:
Journal of Molecular and Cellular Cardiology. 42:804-811
Elevated activities of the sympathetic nerve and renin-angiotensin systems are common features of heart failure. This study was designed to investigate the roles of the AT1 receptor in cardiac hypertrophy and oxidative stress during excessive beta-ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b28735dde699457b80ed63036826a27
https://doi.org/10.1016/j.yjmcc.2007.01.012
https://doi.org/10.1016/j.yjmcc.2007.01.012
Autor:
Akira Miyatake, Yoshihide Fujisawa, Akira Nishiyama, Youichi Abe, Shoji Kimura, Katsuyuki Miura, Yukiko Nagai
Publikováno v:
European Journal of Pharmacology. 558:128-132
The present study aimed to assess the effects of rat adrenomedullin 2 on systemic and regional hemodynamics in conscious Wistar Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs). Intravenous infusion of rat adrenomedullin 2 (0.25-5 micro g/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af4efe433e1a6e26b67752ab3f469c6
https://doi.org/10.1016/j.ejphar.2006.11.043
https://doi.org/10.1016/j.ejphar.2006.11.043
Autor:
Youichi Abe, Shoji Kimura, Kumiko Moriwaki, Toshiki Fukui, Keisuke Matsubara, Hirofumi Hitomi, Akira Nishiyama, Guang Ping Sun, Masakazu Kohno, Koji Ohmori, Hideyasu Kiyomoto, Matlubur Rahman
Publikováno v:
Journal of Hypertension. 24:1089-1095
Objective Mechanical forces and angiotensin II influence the structure and function of vascular cells, and play an important role in reactive oxygen species production. In this study, we examined the effects of mechanical stretch and angiotensin II o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdca78824018aa7ea98e97350ce06269
https://doi.org/10.1097/01.hjh.0000226199.51805.88
https://doi.org/10.1097/01.hjh.0000226199.51805.88
Autor:
Akira Nishiyama, Yoshihide Fujisawa, Akira Miyatake, Shoji Kimura, Takatomi Shokoji, Youichi Abe, Katsuyuki Miura, Yukiko Nagai
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 290:H1120-H1127
Recently, a new member of the calcitonin gene-related peptide (CGRP) family, adrenomedullin 2 (AM2) or intermedin (IMD), was identified. AM2/IMD has been shown to have a vasodilator effect in mice and rats and an effect on urine formation in rats. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a888c302954f343dca469bdd5afde4b
https://doi.org/10.1152/ajpheart.00461.2005
https://doi.org/10.1152/ajpheart.00461.2005
Autor:
Mamoru Fujita, Akira Nishiyama, Akira Miyatake, Shoji Kimura, Yukiko Nagai, Youichi Abe, Guang-Ping Sun, Naohisa Hosomi, Ryoko Baba, Yu-Yan Fan, Masakazu Kohno
Publikováno v:
Hypertension Research. 29:169-178
Recent studies have suggested that aldosterone plays a role in the pathogenesis of renal injury. In this study, we investigated whether local angiotensin II (Ang II) activity contributes to the progression of renal injury in aldosterone/salt-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2def9a3bb3c699a8dc252cb0e82fc187
https://doi.org/10.1291/hypres.29.169
https://doi.org/10.1291/hypres.29.169
Autor:
Guang Ping Sun, Masakazu Kohno, Kumiko Moriwaki, Shoji Kimura, Naoki Kondo, Akira Miyatake, Hideyasu Kiyomoto, Youichi Abe, Taiga Hara, Matlubur Rahman, Akira Nishiyama, Tokunori Yamamoto, Hirofumi Hitomi
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 316:1047-1052
Recent studies have indicated that derangement of peritubular capillary (PTC) circulation with consequent tubulointerstitial hypoxia plays a pivotal role in the pathogenesis of renal injury. The present study was performed to determine whether azelni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b212d682392727c64d831ff34b83c6
https://doi.org/10.1124/jpet.105.095331
https://doi.org/10.1124/jpet.105.095331
Autor:
Matlubur Rahman, Hideyasu Kiyomoto, Youichi Abe, Akira Nishiyama, Akira Miyatake, Shoji Kimura, Masakazu Kohno, Masanori Yoshizumi, Kayoko Miyata, Yukiko Nagai, Guang Ping Sun
Publikováno v:
Hypertension. 46:1039-1045
Recently, we demonstrated that in rats treated chronically with aldosterone and salt, severe tubulointerstitial fibrosis is associated with the activation of mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::332b4a8e5b8bde9ba132e3d6a38b5555
https://doi.org/10.1161/01.hyp.0000174593.88899.68
https://doi.org/10.1161/01.hyp.0000174593.88899.68