Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Youhou Kang"'
Plasma membrane flipping of Syntaxin-2 regulates its inhibitory action on insulin granule exocytosis
Autor:
Fei Kang, Li Xie, Tairan Qin, Yifan Miao, Youhou Kang, Toshimasa Takahashi, Tao Liang, Huanli Xie, Herbert Y. Gaisano
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Kang and colleagues find that plasma membrane flipping of Syntaxin-2 from inside (inhibitory) to outside (relief of inhibition) of pancreatic β-cells helps fine-tune insulin secretion. Increasing this flipping efficiency can alleviate the impaired i
Externí odkaz:
https://doaj.org/article/448e49692c8f483fabaa7e2203e39286
Autor:
Tairan Qin, Tao Liang, Dan Zhu, Youhou Kang, Li Xie, Subhankar Dolai, Shuzo Sugita, Noriko Takahashi, Claes-Goran Ostenson, Kate Banks, Herbert Y. Gaisano
Publikováno v:
EBioMedicine, Vol 16, Iss C, Pp 262-274 (2017)
Reduced pancreatic islet levels of Munc18a/SNARE complex proteins have been postulated to contribute to the deficient glucose-stimulated insulin secretion (GSIS) in type-2 diabetes (T2D). Whereas much previous work has purported Munc18a/SNARE complex
Externí odkaz:
https://doaj.org/article/145a7b2011d04b458ebc56f90b2ef7b3
Publikováno v:
Molecular Metabolism, Vol 4, Iss 5, Pp 418-426 (2015)
Objective: Pancreatic beta-cells express three Munc18 isoforms. Much is known about the roles of Munc18a (pre-docked secretory granules-SGs) and Munc18b (newcomer SGs and SG–SG fusion) in insulin exocytosis. Although shown to influence glucose-stim
Externí odkaz:
https://doaj.org/article/ec89d30bb5444ba39312b339dcd26536
Autor:
Li Xie, Subhankar Dolai, Youhou Kang, Tao Liang, Huanli Xie, Tairan Qin, Lu Yang, Liangyi Chen, Herbert Y Gaisano
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0147862 (2016)
Syntaxin (Syn)-1A mediates exocytosis of predocked insulin-containing secretory granules (SGs) during first-phase glucose-stimulated insulin secretion (GSIS) in part via its interaction with plasma membrane (PM)-bound L-type voltage-gated calcium cha
Externí odkaz:
https://doaj.org/article/63bfa688542b47c09d74086078d09441
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67561 (2013)
The exocyst complex subunit Sec5 is a downstream effector of RalA-GTPase which promotes RalA-exocyst interactions and exocyst assembly, serving to tether secretory granules to docking sites on the plasma membrane. We recently reported that RalA regul
Externí odkaz:
https://doaj.org/article/ed33d249fe4d435bacbdda39b62f2d86
Autor:
Li Xie, Tao Liang, Yi-Fan Miao, Tairan Qin, Mark S. Cattral, Subhankar Dolai, Huanli Xie, Toshimasa Takahashi, Paul A Roche, Erin Winter, Justin Manuel, Fei Kang, Herbert Y. Gaisano, Youhou Kang
Publikováno v:
Autophagy
Intrapancreatic trypsin activation by dysregulated macroautophagy/autophagy and pathological exocytosis of zymogen granules (ZGs), along with activation of inhibitor of NFKB/NF-κB kinase (IKK) are necessary early cellular events in pancreatitis. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa951c98b56f75b70b3873d8fb6ee55
Autor:
Tao Liang, Dan Zhu, Herbert Y. Gaisano, Dafna Greitzer-Antes, Subhankar Dolai, Youhou Kang, Tairan Qin, Yan He, Li Xie, Alexandre B. Hardy, Fei Kang, Huanli Xie
Publikováno v:
Journal of Biological Chemistry. 293:6893-6904
The voltage-dependent K+ (Kv) channel Kv2.1 is a major delayed rectifier in many secretory cells, including pancreatic β cells. In addition, Kv2.1 has a direct role in exocytosis at an undefined step, involving SNARE proteins, that is independent of
Autor:
Kacey J. Prentice, Tao Liang, Youhou Kang, Michael B. Wheeler, Subhankar Dolai, Herbert Y. Gaisano, Lucy R. Osborne, Dan Zhu, Tairan Qin, Li Xie
Publikováno v:
Journal of Biological Chemistry. 292:2203-2216
In type-2 diabetes (T2D), severely reduced islet syntaxin-1A (Syn-1A) levels contribute to insulin secretory deficiency. We generated β-cell-specific Syn-1A-KO (Syn-1A-βKO) mice to mimic β-cell Syn-1A deficiency in T2D. Glucose tolerance tests sho
Autor:
Deborah C. Rubin, Jakob Bondo Hansen, Subhankar Dolai, Herbert Y. Gaisano, Tairan Qin, Huanli Xie, Youhou Kang, Tao Liang, Lucy R. Osborne, Li Xie, Dan Zhu
Publikováno v:
Diabetes
Of the four syntaxins specialized for exocytosis, syntaxin (Syn)-2 is the least understood. In this study, we used Syn-2/epimorphin knockout mice to examine the role of Syn-2 in insulin secretory granule (SG) exocytosis. Unexpectedly, Syn-2 knockout
Autor:
Robert K. Baker, Youhou Kang, Dan Zhu, Claes-Göran Östenson, Herbert Y. Gaisano, Fei Kang, Subhankar Dolai, Timothy J. Kieffer, Daorong Feng, Jeffrey E. Pessin, Li Xie, Tairan Qin, Kate Banks, Dafna Greitzer-Antes, Eva Tudurí, Tao Liang
Publikováno v:
JCI insight. 5(3)
SNAP23 is the ubiquitous SNAP25 isoform that mediates secretion in non-neuronal cells, similar to SNAP25 in neurons. However, some secretory cells like pancreatic islet β cells contain an abundance of both SNAP25 and SNAP23, where SNAP23 is believed