Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Youheng Shu"'
Autor:
James C. Hershey, Youheng Shu, Cheng Wang, Julie A. O'Brien, Vanita Puri, Tracy L. Diamond, Shaei Huang, Antonella Converso, Brian C. Magliaro, Jason M. Uslaner, Victor N. Uebele, Kelly-Ann S. Schlegel
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(9)
Antagonism of the mGluR2 receptor has the potential to provide therapeutic benefit to cognitive disorders by elevating synaptic glutamate, the primary excitatory neurotransmitter in the brain. Selective antagonism of the mGluR2 receptor, however, has
Publikováno v:
Steroids. 67:291-304
Aminosterols isolated from the dogfish shark Squalus acanthias are promising therapeutic agents in the treatment of infection and cancer. One of these, MSI-1436, has been shown to possess antimicrobial activity slightly better than squalamine. In thi
Autor:
Wong Michael K C, Yueheng Jiang, Qingbei Zeng, Chung-Her Jenh, Stuart B. Rosenblum, De-Yi Yang, Yuefei Shao, Anilkumar G. Nair, Jingqi Duo, Doug W. Hobbs, Brian F. Mcguinness, Joseph A. Kozlowski, Lisa Guise Zawacki, Neng-Yang Shih, Carolyn DiIanni Carroll, Youheng Shu, Seong Heon Kim
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(4)
The structure-human CXCR3 binding affinity relationship of a series of pyridyl/pyrazinyl-piperazinyl-piperidine derivatives were explored with a focus to improve PK, hERG and metabolic profiles. Several small heterocycles were identified as amide sur
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(11)
Squalamine and three aminosterol analogs have been shown to inhibit bacterial cell growth and induce lysis of large unilamellar phospholipid vesicles. The analogs differ in the identity of the polyamine attached at C3 of the sterol, and the stereoche
Autor:
Gopinadhan N. Anilkumar, Qingbei Zeng, Brian F. Mcguinness, Chung-Her Jenh, Guizhen Dong, Lisa Guise Zawacki, Inna Schulman, Yueheng Jiang, Seong Heon Kim, Yuefei Shao, Youheng Shu, Wong Michael K C, Doug W. Hobbs, Stuart B. Rosenblum, Neng-Yang Shih, James W. Hall, Carolyn DiIanni Carroll, Wensheng Yu, Joseph A. Kozlowski
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(5)
The structure–human CXCR3 binding affinity relationship of a series of pyridyl–piperazinyl-piperidine derivatives was explored. The optimization campaign highlighted the pronounced effect of 2′-piperazine substitution on CXCR3 receptor affinity
Autor:
Cindy E. Nuss, John J. Renger, Thomas S. Reger, Jeanine E. Ballard, Thomayant Prueksaritanont, Susan L. Garson, Mark G. Bock, Youheng Shu, Yuxing Li, Zhi Qiang Yang, Richard L. Kraus, Scott M. Doran, Kenneth E. Rittle, Victor N. Uebele, Rowena V. Cube, Cuyue Tang, Phung Bondiskey, Schlegel Kelly-Ann, Yuhsin Kuo, Steven V. Fox, James C. Barrow, George D. Hartman
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(17)
The discovery and synthesis of 4,4-disubstituted quinazolinones as T-type calcium channel antagonists is reported. Based on lead compounds 2 and 3, a focused SAR campaign driven by the optimization of potency, metabolic stability, and pharmacokinetic
Autor:
Len Favreau, Chunli Huang, Guowei Zhou, Neng-Yang Shih, Waldemar Gonsiorek, R. William Hipkin, Charles A. Lunn, Ling Tong, Joseph A. Kozlowski, Joseph Kelly, Lei Chen, Brian J. Lavey, Asra Malikzay, Razia Rizvi, Eric J. Gilbert, Bandarpalle B. Shankar, Daniel Lundell, Wong Michael K C, Stuart W. McCombie, Youhao Dong, Youheng Shu
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(2)
The triaryl bis-sulfone 1 was modified by converting the aryl A-ring to a piperidine ring. The piperidine ring was further elaborated to a spirocyclopropyl piperidine moiety. The effect on CB2 binding potency, rat calcium channel affinity, and CYP 2C
Autor:
Guowei Zhou, Stuart W. McCombie, Neng-Yang Shih, De-Yi Yang, Bandarpalle B. Shankar, Youheng Shu, Razia Rizvi, Spitler James M, Brian J. Lavey, Michael K. C. Wong, Charles A. Lunn, Jie Wu, Joseph A. Kozlowski, Shing-Chun Wong, Ronald L. Wolin
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(13)
Structure-activity relationship on our recently reported triaryl bis-sulfone class of cannabinoid-2 (CB2) receptor selective inverse agonists was explored. Modifications to the methane sulfonamide, substitutions to B and C phenyl rings, and replaceme
Autor:
Zhi-Qiang Yang, James C. Barrow, William D. Shipe, Kelly-Ann S. Schlegel, Youheng Shu, F. Vivien Yang, Craig W. Lindsley, Kenneth E. Rittle, Mark G. Bock, George D. Hartman, Victor N. Uebele, Cindy E. Nuss, Steve V. Fox, Richard L. Kraus, Scott M. Doran, Thomas M. Connolly, Cuyue Tang, Jeanine E. Ballard, Yuhsin Kuo, Emily D. Adarayan
Publikováno v:
Journal of Medicinal Chemistry; Oct2008, Vol. 51 Issue 20, p6471-6477, 7p
Autor:
William D. Shipe, James C. Barrow, Zhi-Qiang Yang, Craig W. Lindsley, F. Vivien Yang, Kelly-Ann S. Schlegel, Youheng Shu, Kenneth E. Rittle, Mark G. Bock, George D. Hartman, Cuyue Tang, Jeanine E. Ballard, Yuhsin Kuo, Emily D. Adarayan, Thomayant Prueksaritanont, Matthew M. Zrada, Victor N. Uebele, Cindy E. Nuss, Thomas M. Connolly, Scott M. Doran
Publikováno v:
Journal of Medicinal Chemistry; Jun2008, Vol. 51 Issue 13, p3692-3695, 4p