Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Youge, Qu"'
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106573- (2024)
Arketamine, the (R)-enantiomer of ketamine, exhibits antidepressant-like effects in mice, though the precise molecular mechanisms remain elusive. It has been shown to reduce splenomegaly and depression-like behaviors in the chronic social defeat stre
Externí odkaz:
https://doaj.org/article/26018cb3c1ee4c3ba099a562268435a4
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Relapse is common in remitted patients with major depressive disorder (MDD). Arketamine, an (R)-enantiomer of ketamine, has persistent prophylactic actions in an inflammatory model of depression. However, the precise mechanisms underlying th
Externí odkaz:
https://doaj.org/article/14d4644e5abb4c0caa0e40b099c8973b
Autor:
Ji-chun Zhang, Wei Yao, Youge Qu, Mayumi Nakamura, Chao Dong, Chun Yang, Qian Ren, Min Ma, Mei Han, Yukihiko Shirayama, Akiko Hayashi-Takagi, Kenji Hashimoto
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/620dec1f3a5f4e33ada6cb176524d32d
Publikováno v:
Neurobiology of Disease, Vol 189, Iss , Pp 106348- (2023)
3,4-Methylenedioxymethamphetamine (MDMA) is the most widely used illicit substance worldwide. Nevertheless, recent observational studies demonstrated that lifetime MDMA use among U.S. adults was associated with a lower risk of depression and suicide
Externí odkaz:
https://doaj.org/article/b99b74a470064b50bdf194786c4569e9
Autor:
Qianqian Cao, Shilin Luo, Wei Yao, Youge Qu, Nanbu Wang, Jian Hong, Shigeo Murayama, Zhentao Zhang, Jiaxu Chen, Kenji Hashimoto, Qi Qi, Ji-chun Zhang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 1-15 (2022)
Parkinson’s disease (PD) is characterized by the formation of Lewy bodies (LBs) in the brain. LBs are mainly composed of phosphorylated and aggregated α-synuclein (α-Syn). Thus, strategies to reduce the expression of α-Syn offer promising therap
Externí odkaz:
https://doaj.org/article/8c17e102840846bdafb031880634a5c8
Autor:
Li Ma, Long Wang, Lijia Chang, Jiajing Shan, Youge Qu, Xingming Wang, Xiayun Wan, Yuko Fujita, Kenji Hashimoto
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract (R,S)-ketamine is known to elicit persistent prophylactic effects in rodent models of depression. However, the precise molecular mechanisms underlying its action remain elusive. Using RNA-sequencing analysis, we searched for novel molecular
Externí odkaz:
https://doaj.org/article/df5f5097b6214dbdbd5dcd4d24b0004a
Autor:
Qianqian Cao, Qiuming Zou, Xin Zhao, Yimin Zhang, Youge Qu, Nanbu Wang, Shigeo Murayama, Qi Qi, Kenji Hashimoto, Song Lin, Ji-chun Zhang
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract Mounting evidence suggests the key role of brain-derived neurotrophic factor (BDNF) in the dopaminergic neurotoxicity of Parkinson’s disease (PD). Activation of NF-E2-related factor-2 (Nrf2) and inhibition of methyl CpG-binding protein 2 (
Externí odkaz:
https://doaj.org/article/e90b28b6ad0f4c5f9c7a088517e7bbc0
Autor:
Li Ma, Jiancheng Zhang, Yuko Fujita, Youge Qu, Jiajing Shan, Xiayun Wan, Xingming Wang, Tamaki Ishima, Kenta Kobayashi, Long Wang, Kenji Hashimoto
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract (R, S)-ketamine has prophylactic antidepressant-like effects in rodents; however, the precise molecular mechanisms underlying its action remain unknown. Using RNA-sequencing analysis, we searched novel molecular target(s) that contribute to
Externí odkaz:
https://doaj.org/article/f32c469a36c84859a13c5db52a93723a
Autor:
Xiayun Wan, Akifumi Eguchi, Akemi Sakamoto, Yuko Fujita, Yong Yang, Youge Qu, Masahiko Hatano, Chisato Mori, Kenji Hashimoto
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 27, Iss , Pp 100573- (2023)
The spleen is a key immune-related organ that plays a role in communication between the brain and the immune system through the brain–spleen axis and brain–gut–microbiota axis. However, how the gut microbiota affects spleen and brain function r
Externí odkaz:
https://doaj.org/article/b09c183c2e494510ac27cc4cee4adb38
Autor:
Xingming Wang, Akifumi Eguchi, Yong Yang, Lijia Chang, Xiayun Wan, Jiajing Shan, Youge Qu, Li Ma, Chisato Mori, Jianjun Yang, Kenji Hashimoto
Publikováno v:
Neurobiology of Disease, Vol 176, Iss , Pp 105951- (2023)
Multiple sclerosis (MS) is the most common demyelinating disease that attacks the central nervous system. Dietary intake of cuprizone (CPZ) produces demyelination resembling that of patients with MS. Given the role of the vagus nerve in gut–microbi
Externí odkaz:
https://doaj.org/article/433f4dbddf26483f83aae9dde784c582