Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Youg Raj, Thaker"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Activation of T cells in the tumor microenvironment can be inhibited through a variety of mechanisms. Here, the authors show that Rasal1, a GTPase-activating protein, binds and inhibits signaling downstream of the T Cell Receptor complex and that con
Externí odkaz:
https://doaj.org/article/5e3f7af3677d4cc6984ba9564955a165
Autor:
Nelson Fernandez, Christopher E. Rudd, Asha Recino, Youg Raj Thaker, Asma Jabeen, Maja Wallberg, Monika Raab
Publikováno v:
The Journal of Biological Chemistry
The adaptor protein Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) plays a crucial role in T cell activation by linking antigen receptor (T cell receptor, TCR) signals to downstream pathways. At its N terminus, SLP-76 ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4658469bc20e68b3043e0f5b01c14f2e
https://doi.org/10.1074/jbc.m116.759555
https://doi.org/10.1074/jbc.m116.759555
Autor:
Youg Raj Thaker, Bijender K. Bajaj
Publikováno v:
World Journal of Microbiology and Biotechnology. 35
Unfortunately, The first author’s name has been incorrectly published in the original publication of the article. The correct name of the author is “Youg Raj Thaker”.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7928289eebdf9023d092621020fdb8a7
https://doi.org/10.1007/s11274-019-2725-7
https://doi.org/10.1007/s11274-019-2725-7
Autor:
Vladimir, Marshansky, Hiroyuki, Hosokawa, Maria, Merkulova, Anastasia, Bakulina, Phat Vinh, Dip, Youg Raj, Thaker, Ajay, Bjargava, James R, Tonra, Dennis A, Ausiello, Gerhard, Grüber
Publikováno v:
Current topics in membranes. 83
We have previously identified the interaction between mammalian V-ATPase a2-subunit isoform and cytohesin-2 (CTH2) and studied molecular details of binding between these proteins. In particular, we found that six peptides derived from the N-terminal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::584db6eedb194811fe2733527b9055cc
https://pubmed.ncbi.nlm.nih.gov/31196611
https://pubmed.ncbi.nlm.nih.gov/31196611
Autor:
Jessica Buck, Bruce R. Blazar, Peter T. Sage, Sun Jung Lee, Shannon L. McArdel, Qianxia Zhang, Vikram R. Juneja, Arlene H. Sharpe, Scott B. Lovitch, Loise M. Francisco, Catherine L. Tan, Dario A. A. Vignali, Christine G. Lian, Gordon J. Freeman, Youg Raj Thaker, Dan Liang, George F. Murphy, Juhi R. Kuchroo
Publikováno v:
The Journal of Experimental Medicine
Tan et al. provide novel insights into understanding how PD-1 regulates regulatory T (T reg) cells. More specifically, this study demonstrates that loss of PD-1 on T reg cells leads to enhanced T reg cell suppressor function in vitro and in vivo. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5756deb59f0ade163585a718edaede2a
https://pubmed.ncbi.nlm.nih.gov/33045061
https://pubmed.ncbi.nlm.nih.gov/33045061
Publikováno v:
The Journal of Immunology. 202:184.4-184.4
T-cell activation is needed for responses to antigen and controls responses to foreign antigen and cancer neo-antigens in immunotherapy. The full range of signaling events that inhibit T-cell activation and limit anti-tumor reactivity is unclear. Pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::410b0ad216946e2dd5fb019b0c61549b
https://doi.org/10.4049/jimmunol.202.supp.184.4
https://doi.org/10.4049/jimmunol.202.supp.184.4
Autor:
Christopher E. Rudd, Helga Schneider, Hebin Liu, Youg Raj Thaker, Loren J. Stagg, John E. Ladbury
Publikováno v:
The Journal of Biological Chemistry
Background: SLP-76 possesses an N-terminal sterile α motif (SAM) domain of unknown function. Results: SLP-76 SAM and its isolated H5 domain self-associates for microclusters and NFAT transcription. Conclusion: SLP-76 self-associates in response to T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbeb2fd1db2cb1fcdc427c14331c28e5
https://doi.org/10.1074/jbc.m112.424846
https://doi.org/10.1074/jbc.m112.424846
Publikováno v:
The Journal of Immunology. 200:101.7-101.7
The inhibitory receptor Lymphocyte activation gene 3 (LAG3; CD223) plays a key role in regulating T cell activation and tolerance. LAG3 can be expressed on CD4+ FoxP3+ regulatory T cells (Tregs) and conventional effector T cells (Tcons). We found tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c77c770f68fa9977109f53bf51571d63
https://doi.org/10.4049/jimmunol.200.supp.101.7
https://doi.org/10.4049/jimmunol.200.supp.101.7
Autor:
Sankaranarayanan Rishikesan, Malathy Sony Subramanian Manimekalai, Yin Hoe Yau, Susana Geifman Shochat, Subramanian Vivekanandan, Shovanlal Gayen, Gerhard Grüber, Youg Raj Thaker
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1787:242-251
Understanding the structural traits of subunit G is essential, as it is needed for V(1)V(O) assembly and function. Here solution NMR of the recombinant N- (G(1-59)) and C-terminal segment (G(61-114)) of subunit G, has been performed in the absence an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee800cd457b1dabfffaee3b2cbb1e2a
https://doi.org/10.1016/j.bbabio.2009.01.010
https://doi.org/10.1016/j.bbabio.2009.01.010
Publikováno v:
FEBS Letters. 583:1090-1095
Owing to the complex nature of V1VO ATPases, identification of neighboring subunits is essential for mechanistic understanding of this enzyme. Here, we describe the links between the V1 headpiece and the VO-domain of the yeast V1VO ATPase via subunit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b340ee283182847b4958142b21b67737
https://doi.org/10.1016/j.febslet.2009.03.013
https://doi.org/10.1016/j.febslet.2009.03.013