Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Youcun Qian"'
Autor:
Tao Yang, Guodong Wang, Mingxiang Zhang, Xiaohu Hu, Qi Li, Fenglin Yun, Yingying Xing, Xinyang Song, Haibing Zhang, Guohong Hu, Youcun Qian
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113377- (2023)
Summary: ZBP1 senses viral Z-RNAs to induce necroptotic cell death to restrain viral infection. ZBP1 is also thought to recognize host cell-derived Z-RNAs to regulate organ development and tissue inflammation in mice. However, it remains unknown how
Externí odkaz:
https://doaj.org/article/d9ce3c12964e4a4497d84d11113718a9
Autor:
Xinrui Shao, Siyuan Chen, Daping Yang, Mengtao Cao, Yikun Yao, Zhengxi Wu, Ningli Li, Nan Shen, Xiaoxia Li, Xinyang Song, Youcun Qian
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract IL-17 is a pro-inflammatory cytokine implicated a variety of autoimmune diseases. We have recently reported that FGF2 cooperates with IL-17 to protect intestinal epithelium during dextran sodium sulfate (DSS)-induced colitis. Here, we report
Externí odkaz:
https://doaj.org/article/73c7aea82a264b86b2b5961d19bf7011
Autor:
Meng Xia, Juan Liu, Shuxun Liu, Kun Chen, Hongyu Lin, Minghong Jiang, Xiaoqing Xu, Yiquan Xue, Wei Liu, Yan Gu, Xiang Zhang, Zhiqing Li, Lin Yi, Youcun Qian, Chen Zhou, Ru Li, Xuan Zhang, Zhanguo Li, Xuetao Cao
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The transcriptional program activated by Smad2/Smad3 is critical for the induction and function of regulatory T cells. Here the authors show that the expression of Smad3 is modulated by the complementary functions of a methyltransferase Ash1l and an
Externí odkaz:
https://doaj.org/article/330b9b0908f84e2aabfc8b87a44e5027
Autor:
Yikun Yao, Siyuan Chen, Mengtao Cao, Xing Fan, Tao Yang, Yin Huang, Xinyang Song, Yongqin Li, Lilin Ye, Nan Shen, Yufang Shi, Xiaoxia Li, Feng Wang, Youcun Qian
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Perforin is part of the cytotoxic effector mechanism of CD8+ T cells. Here the authors show that antigen-induced perforin release from CD8 T cells into antigen-presenting cells can activate NLRP3 inflammasome to constitute a positive feedback loop to
Externí odkaz:
https://doaj.org/article/d1e62bdfffbc49eca8c485e2ff13f254
Autor:
Chenhui Wang, Cun-Jin Zhang, Bradley N. Martin, Katarzyna Bulek, Zizhen Kang, Junjie Zhao, Guanglin Bian, Julie A. Carman, Ji Gao, Ashok Dongre, Haibo Xue, Stephen D. Miller, Youcun Qian, Dolores Hambardzumyan, Tom Hamilton, Richard M. Ransohoff, Xiaoxia Li
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
NOTCH signalling stimulates oligodendrocyte progenitor cell proliferation but how this regulates demyelinating disease is unclear. Here, the authors show that an IL-17 adaptor protein, Act1, interacts with the C-terminal fragment of NOTCH1 (NICD) to
Externí odkaz:
https://doaj.org/article/6cf86ce31a16462e8d6947a6f2906f20
Autor:
Jing Xu, Siyu Pei, Yan Wang, Junli Liu, Youcun Qian, Mingzhu Huang, Yanyun Zhang, Yichuan Xiao
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Myeloid derived suppressor cells (MDSC) in the liver microenvironment protects against the inflammation-induced liver injury in fulminant hepatitis (FH). However, the molecular mechanism through which MDSC is recruited into the inflamed liver remain
Externí odkaz:
https://doaj.org/article/e6c0454861094bbb855c3cbe3ee60a91
Publikováno v:
Immunology
Host−microbiota interaction plays fundamental roles in the homeostasis of mucosal immunity. Dysbiosis of intestinal microbiota has been demonstrated to participate in various immune responses and many multifactorial diseases. Study of intestinal mi
Autor:
Qi Li, Zhengxi Wu, Wenli Lu, Haibing Zhang, Ming Li, Yifan Zhang, Jie Zhang, Yikun Yao, Youcun Qian, Mengtao Cao, Qun Zhao, Qi Lou
Publikováno v:
Cell Death Differ
Necroptosis is a recently defined type of programmed cell death with the specific signaling cascade of receptor-interacting protein 1 (RIPK1) and RIPK3 complex to activate the executor MLKL. However, the pathophysiological roles of necroptosis are la
Autor:
Xianzhe Lv, Hongxia Wang, Jili Wen, Tianhao Zhou, Wenjing Zhao, Min Cong, Yichuan Xiao, Yansen Xiao, Shuaixi Yang, Pu Tian, Wenqian Luo, Qiang Gao, Chenxi Liang, Qiuyao Wu, Guohong Hu, Dasa He, Qingcheng Yang, Youcun Qian, Xingwang Zhang, Yajun Liang, Qifeng Yang, Yingjie Liu, Dong-dong Cheng, Yuan Wang, Peiyuan Zhang, Yunfei He, Jiatao Li
Publikováno v:
Cancer cell. 39(3)
Lung metastasis is the major cause of breast cancer-related mortality. The neutrophil-associated inflammatory microenvironment aids tumor cells in metastatic colonization in lungs. Here, we show that tumor-secreted protease cathepsin C (CTSC) promote
Autor:
Rui Wu, Feng Wang, Huijuan Wu, Xuanchen Liu, Youcun Qian, Niansong Wang, Jianyong Yin, Xiulei Cai
Publikováno v:
Metabolism. 83:18-24
Background and Objective Interleukin 6 (IL-6) has been identified as a key mediator in inflammation, immune responses and glucose metabolism. In this study, we assessed the effects of an IL-6 receptor antibody on diabetic nephropathy in a mouse model