Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Youchao, Deng"'
Autor:
Youchao Deng (邓友超)
Publikováno v:
ECNU Review of Education, Vol 7 (2024)
Highlights We live in a technology-driven age, so the education field must rationally consider chatbots powered by artificial intelligence (AI). Faced with increasing application of AI in education, teachers should be reflective educators, and studen
Externí odkaz:
https://doaj.org/article/2401c84d2707495bbd2f12c611563ab7
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 12, Pp 4893-4905 (2023)
Protein arginine methyltransferases (PRMTs) are attractive targets for developing therapeutic agents, but selective PRMT inhibitors targeting the cofactor SAM binding site are limited. Herein, we report the discovery of a noncanonical but less polar
Externí odkaz:
https://doaj.org/article/20ea3f0876a041129c1e09a657e85ca3
Autor:
Danfeng Cao, Jie Yang, Youchao Deng, Meng Su, Yeji Wang, Xueqiong Feng, Yi Xiong, Enhe Bai, Yanwen Duan, Yong Huang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/23fc6fe9be26407b82b0a76c3ed73bfd
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2709-2718 (2021)
Protein arginine methyltransferases (PRMTs) have been implicated in the progression of many diseases. Understanding substrate recognition and specificity of individual PRMT would facilitate the discovery of selective inhibitors towards future drug di
Externí odkaz:
https://doaj.org/article/94de89932623487b8bf535b282a1cf58
Publikováno v:
Natural Gas Industry B, Vol 7, Iss 6, Pp 648-655 (2020)
Fracturing equipment is the core device in shale gas reservoir stimulation. As domestic shale gas exploration and development steps into deep layers, the development of fracturing technology puts forward higher requirements for relevant equipment. El
Externí odkaz:
https://doaj.org/article/3a0b793927e24573a3f1da08fb24d620
Autor:
Jujun Zhou, Youchao Deng, Iredia D. Iyamu, John R. Horton, Dan Yu, Taraneh Hajian, Masoud Vedadi, Dante Rotili, Antonello Mai, Robert M. Blumenthal, Xing Zhang, Rong Huang, Xiaodong Cheng
Publikováno v:
ACS Chemical Biology. 18:734-745
Autor:
Youchao Deng, Yuling Li, Zhongqing Wen, Claudia H. Ruiz, Xiang Weng, Michael D. Cameron, Yanwen Duan, Yong Huang
Publikováno v:
Antibiotics, Vol 11, Iss 4, p 425 (2022)
Type II fatty acid synthases are promising drug targets against major bacterial pathogens. Platensimycin (PTM) is a potent inhibitor against β-ketoacyl-[acyl carrier protein] synthase II (FabF) and β-ketoacyl-[acyl carrier protein] synthase I (FabB
Externí odkaz:
https://doaj.org/article/fdacf75b6e434256b3578b2646910920
Publikováno v:
Journal of Medicinal Chemistry. 66:1601-1615
Autor:
Liao-Bin Dong, Jeffrey D. Rudolf, Dingding Kang, Nan Wang, Cyndi Qixin He, Youchao Deng, Yong Huang, K. N. Houk, Yanwen Duan, Ben Shen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Thioplatensimycin (thioPTM) and thioplatencin (thioPTN) are recently discovered thiocarboxylic acid congeners of the antibacterial compounds PTM and PTN. Here, the authors identify a thioacid cassette encoding PtmA3 and PtmU4 that are responsible for
Externí odkaz:
https://doaj.org/article/e89626e016aa4682b96d98ed37e5b624
Autor:
Guangping Dong, Youchao Deng, Adam Yasgar, Ravi Yadav, Daniel Talley, Alexey V. Zakharov, Sankalp Jain, Ganesha Rai, Nicholas Noinaj, Anton Simeonov, Rong Huang
Publikováno v:
Journal of Medicinal Chemistry. 65:12334-12345
Venglustat is a known allosteric inhibitor for ceramide glycosyltransferase, investigated in diseases caused by lysosomal dysfunction. Here, we identified venglustat as a potent inhibitor (IC