Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Youcef Mehellou"'
Autor:
Olivia A Lambourne, Shane Bell, Lea P Wilhelm, Erika B Yarbrough, Gabriel G Holly, Oliver M Russell, Arwa Alghamdi, Azeza M Fdel, Carmine Varricchio, Emma L Lane, Ian G Ganley, Arwyn T Jones, Matthew S Goldberg, Youcef Mehellou
The phosphorylation of ubiquitin by the mitochondrial protein kinase PINK1, upon mitochondrial depolarization, is an important step in the repair and recycling of the mitochondria via mitophagy. As mutations in PINK1 can cause early-onset Parkinson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78095e08f1981ed3d6849627cca3ac5e
https://doi.org/10.26434/chemrxiv-2022-vcp3x
https://doi.org/10.26434/chemrxiv-2022-vcp3x
Publikováno v:
Journal of Medicinal Chemistry. 64:16703-16710
Intracellular phosphorylation of therapeutic nucleoside analogues into their active triphosphate metabolites is a prerequisite for their pharmacological activity. However, the initial phosphorylation of these unnatural nucleosides into their monophos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b758b4c76a70df25cac257487ef898b
https://doi.org/10.1021/acs.jmedchem.1c01490
https://doi.org/10.1021/acs.jmedchem.1c01490
Publikováno v:
Biochemical and Biophysical Research Communications. 532:88-93
SPAK and OSR1 are two cytoplasmic serine/threonine protein kinases that regulate the function of a series of sodium, potassium and chloride co-transporters via phosphorylation. Over recent years, it has emerged that these two kinases may have diverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c8a54401dc8b9818d55f5d5d6500d6
https://doi.org/10.1016/j.bbrc.2020.07.143
https://doi.org/10.1016/j.bbrc.2020.07.143
Autor:
Taher E. Taher, Richard T. Bryan, Youcef Mehellou, Benjamin E. Willcox, Elizabeth Ashby, Maria Sharif, Hachemi Kadri, Qin Xu
Publikováno v:
Journal of Medicinal Chemistry
Vγ9/Vδ2 T-cells are activated by pyrophosphate-containing small molecules known as phosphoantigens (PAgs). The presence of the pyrophosphate group in these PAgs has limited their drug-like properties because of its instability and polar nature. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1396a8819eae3a345032e3f645e31b0
http://europepmc.org/articles/PMC7549095
http://europepmc.org/articles/PMC7549095
Publikováno v:
Chemmedchem
Aryloxy triester phosphoramidate prodrugs of the monophosphate derivatives of isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP) were synthesized as lipophilic derivatives that can improve cell uptake. Despite the structural simi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb9719401f86606fa2bfe30fd95aceb
https://orca.cardiff.ac.uk/id/eprint/140886/7/cmdc.202100198.pdf
https://orca.cardiff.ac.uk/id/eprint/140886/7/cmdc.202100198.pdf
Autor:
Youcef Mehellou, Binar Asrining Dhiani
Publikováno v:
ChemBioChem. 21:638-643
SPAK and OSR1 are two protein kinases that play critical roles in regulating ion homeostasis. They are activated under osmotic stress through phosphorylation by their upstream WNK kinases at a conserved threonine site on their T-loops. Additionally,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5232ff2edd470cc542fb09f2219cfa06
https://doi.org/10.1002/cbic.201900454
https://doi.org/10.1002/cbic.201900454
Publikováno v:
ACS Medicinal Chemistry Letters. 10:2-5
[Image: see text] The ProTide prodrug technology has proved very useful in the discovery of nucleotide therapeutics and has successfully led to two FDA-approved drugs. However, with the extensive application of this prodrug approach to nucleotides fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231831946bb4a7bf97d3e8232950aae9
https://doi.org/10.1021/acsmedchemlett.8b00586
https://doi.org/10.1021/acsmedchemlett.8b00586
COVID19 has caused thousands of deaths worldwide within a few months. The rapid spread of this virus that causes COVID19, termed SARS CoV2, has been facilitated by the lack of effective vaccines and treatments against this virus. In recent months, ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6905b1619b0b0c40be30dbd662db8a
https://doi.org/10.26434/chemrxiv.12170337
https://doi.org/10.26434/chemrxiv.12170337
Autor:
Hachemi Kadri, Youcef Mehellou, Binar Asrining Dhiani, Ageo Miccoli, Olivia A. Lambourne, Peter J. Thornton, Edward James
Publikováno v:
ChemMedChem, 2020, Vol.15(8), pp.671-674 [Peer Reviewed Journal]
The specific targeting of protein‐protein interactions by phosphoserine‐containing small molecules has been scarce due to the dephosphorylation of phosphoserine and its charged nature at physiological pH, which hinders its uptake into cells. To a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb95e8a833c4645b1a4b8e382fb148a
https://doi.org/10.1002/cmdc.202000034
https://doi.org/10.1002/cmdc.202000034
Publikováno v:
ChemBioChem. 19:2072-2080
STE20/SPS1-related proline/alanine-rich kinase (SPAK) and oxidative-stress-responsive kinase 1 (OSR1) are two serine/threonine protein kinases that play key roles in regulating ion homeostasis. Various SPAK and OSR1 mouse models exhibited reduced blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5fe9d26854eb4498c7edc1a827a9f7
https://doi.org/10.1002/cbic.201800272
https://doi.org/10.1002/cbic.201800272