Zobrazeno 1 - 10
of 57
pro vyhledávání: '"You-Qing Zhang"'
Autor:
Tingting Mo, Yefen Zou, Weijun Shen, Zhihong Huang, Xiaoyue Zhang, Qihui Jin, Jing Li, Shifeng Pan, Michael Di Donato, Loren Jon, Andrew M. Schumacher, George Harb, Shanshan Yan, Anwesh Kamireddy, You-Qing Zhang, Tom Y.-H. Wu, Yong Jia, Xueshi Hao, Yahu A. Liu, Richard Glynne, Bryan Laffitte, Brandon Taylor, Peter McNamara, Qiang Ding, Wenqi Gao, Valentina Molteni, Badry Bursalaya, Lisa Deaton, Chun Li
Publikováno v:
ChemMedChem. 15:1562-1570
Loss of β-cell mass and function can lead to insufficient insulin levels and ultimately to hyperglycemia and diabetes mellitus. The mainstream treatment approach involves regulation of insulin levels; however, approaches intended to increase β-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d25eb2a68736314c37d5245dad02a1
https://doi.org/10.1002/cmdc.202000183
https://doi.org/10.1002/cmdc.202000183
Autor:
Bo Liu, Sukwon Ha, H. Michael Petrassi, Kate Jacobsen, George Harb, W. Perry Gordon, Bryan Laffitte, Thanh Lam, Qihui Jin, Yong Jia, Janine E. Baaten, Minhua Qiu, Robert Hill, Shelly Meeusen, Shanshan Yan, Badry Bursulaya, Valentina Molteni, Anwesh Kamireddy, Lisa Deaton, Jianfeng Pan, You-Qing Zhang, Loren Jon, Michael DiDonato, Yahu A. Liu, Shifeng Pan, Andrew M. Schumacher, Tingting Mo, Yefen Zou, Xiaoyue Zhang, Weijun Shen, Karyn Colman, Richard Glynne, Xueshi Hao, Peter McNamara, Vân Nguyen-Tran, Zhicheng Wang, Sheryll Espinola, Bao Nguyen, Tom Y.-H. Wu, Jing Li, Qiang Ding
Publikováno v:
Journal of Medicinal Chemistry. 63:2958-2973
Autoimmune deficiency and destruction in either β-cell mass or function can cause insufficient insulin levels and, as a result, hyperglycemia and diabetes. Thus, promoting β-cell proliferation could be one approach toward diabetes intervention. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222e5ae5085b8fd7b08c90167919a793
https://doi.org/10.1021/acs.jmedchem.9b01624
https://doi.org/10.1021/acs.jmedchem.9b01624
Autor:
Richard Glynne, Bryan Laffitte, Peter McNamara, George Harb, Weidong Wang, V. Deshmukh, Matthew S. Tremblay, Charles Y. Cho, You Qing Zhang, Ann E. Herman, Peter G. Schultz, Jonathan G. Swoboda, Janine E. Baaten, Weijun Shen, Tom Y.-H. Wu, Christophe M. Filippi, Jing Li, Qihui Jin, Anwesh Kamireddy, Xu Wu
Publikováno v:
Journal of the American Chemical Society. 135:1669-1672
The identification of factors that promote β cell proliferation could ultimately move type 1 diabetes treatment away from insulin injection therapy and toward a cure. We have performed high-throughput, cell-based screens using rodent β cell lines t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75bd49122d522040efaa9a74797d00bd
https://doi.org/10.1021/ja309304m
https://doi.org/10.1021/ja309304m
Autor:
Ayse G. Kayali, Marcie Kritzik, Guoxun Liu, Howard S. Fox, Hong Hua, Nora Sarvetnick, Cory U. Lago, You Qing Zhang, Sandrine Arnaud-Dabernat
Publikováno v:
Endocrine. 37:312-321
The growth and renewal of epithelial tissue is a highly orchestrated and tightly regulated process occurring in different tissue types under a variety of circumstances. We have been studying the process of pancreatic regeneration in mice. We have ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c551b1e6699271772924a7020c3af3b
https://doi.org/10.1007/s12020-009-9297-5
https://doi.org/10.1007/s12020-009-9297-5
Autor:
Sandrine Dabernat, Lori Sterling, Daisy Dietz, Nora Sarvetnick, Hong Hua, You Qing Zhang, Marcie Kritzik
Publikováno v:
Journal of Biological Chemistry. 281:13574-13580
Inhibitor of DNA binding (Id) proteins bind to and inhibit the function of basic helix-loop-helix (bHLH) transcription factors including those that regulate pancreatic development. Moreover, bone morphogenetic proteins (BMPs) regulate the expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4914ac79cfef43d76b22346013c8b4b
https://doi.org/10.1074/jbc.m600526200
https://doi.org/10.1074/jbc.m600526200
Autor:
Ayse G. Kayali, Guoxun Liu, You Qing Zhang, Sandrine Arnaud-Dabernat, Nora Sarvetnick, Marcie Kritzik
Publikováno v:
Endocrine. 30:103-112
Gut peptide YY (PYY) plays an important role in regulating metabolism and is expressed during the ontogeny of the pancreas. However, its biological role during endocrine cell formation is not fully understood, and its role, if any, during pancreatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a89faaa295b4977b46d825794651f5
https://doi.org/10.1385/endo:30:1:103
https://doi.org/10.1385/endo:30:1:103
Autor:
Ayse G. Kayali, Yingjie Si, Mary Malo Cleary, Guoxun Liu, Marcie Kritzik, You Qing Zhang, Nora Sarvetnick, Sandrine Dabernat, Yuzuru Eto
Publikováno v:
Diabetes. 53:2024-2033
Activins regulate the growth and differentiation of a variety of cells. During pancreatic islet development, activins are required for the specialization of pancreatic precursors from the gut endoderm during midgestation. In this study, we probed the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc42f7e9c5bc1a40465894ccc6509ca
https://doi.org/10.2337/diabetes.53.8.2024
https://doi.org/10.2337/diabetes.53.8.2024
Autor:
You-Qing Zhang, Akito Maeshima, Itaru Kojima, Hiroyuki Kuwano, Yoshihisa Hasegawa, Wataru Wada
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 287:E247-E254
We assessed the function of the βC-subunit of activin in hepatocytes. We studied the effect of conditioned medium of Chinese hamster ovary (CHO) cell line stably expressing the βC gene (CHO-βC) on growth of AML12 hepatocytes. We also examined the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f5713c355f90a44a19de43909d1810f
https://doi.org/10.1152/ajpendo.00390.2003
https://doi.org/10.1152/ajpendo.00390.2003
Autor:
Yoshihisa Hasegawa, Masatomo Mori, Takeshi Ichikawa, Kimitaka Kogure, You-Qing Zhang, Hitoshi Takagi, Itaru Kojima
Publikováno v:
Hepatology. 34:918-925
The present study was conducted to assess the role of transforming growth factor beta (TGF-beta) and activin(s) in the regulation of the mass of the liver. To this end, we eliminated TGF-beta or activin signaling in intact rat liver by adenovirus-med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b383a833e72d6b49b79e3143ffccd0
https://doi.org/10.1053/jhep.2001.29132
https://doi.org/10.1053/jhep.2001.29132
Publikováno v:
Journal of the American Society of Nephrology. 12:1685-1695
This study was conducted to investigate the involvement of the activin-follistatin system in renal regeneration after ischemic injury. Expression of mRNA for the activin β A subunit was not detected in normal kidneys but increased markedly after ren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e1bf9a10322b53cf8bf04049c91ca9
https://doi.org/10.1681/asn.v1281685
https://doi.org/10.1681/asn.v1281685