Structure of complement fragment C3b–factor H and implications for host protection by complement regulators.

Autor: Jin Wu¹, You-Qiang Wu², Ricklin, Daniel², Janssen, Bert J. C.¹, Lambris, John D.² lambris@upenn.edu, Gros, Piet¹ p.gros@uu.nl

Publikováno v: Nature Immunology. Jul2009, Vol. 10 Issue 7, p728-733. 6p. 4 Diagrams, 1 Chart, 1 Graph.

Endothelin-1 Signaling Promotes Fibrosis In Vitro in a Bronchopulmonary Dysplasia Model by Activating the Extrinsic Coagulation Cascade

Autor: Konstantinos Ritis, Ioannis Kourtzelis, Stavros Rafail, You-Qiang Wu, George Kolios, Stergios Vradelis, Ioannis Sigalas, Ioannis Mitroulis, Marianna Skordala, Konstantinos Kambas, Akrivi Chrysanthopoulou, Matthaios Speletas

Publikováno v: The Journal of Immunology. 186:6568-6575

Neonatal respiratory distress syndrome can progress to bronchopulmonary dysplasia (BPD), a serious pulmonary fibrotic disorder. Given the involvement of the extrinsic coagulation cascade in animal models of lung fibrosis, we examined its role in BPD.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e1181dd5be2f508790fabac89a2a9b1
https://doi.org/10.4049/jimmunol.1003756

Structure-kinetic relationship analysis of the therapeutic complement inhibitor compstatin

Autor: Paola Magotti, Daniel Ricklin, Hongchang Qu, Yiannis N. Kaznessis, You-Qiang Wu, John D. Lambris

Publikováno v: Journal of Molecular Recognition. 22:495-505

Compstatin is a 13-residue peptide that inhibits activation of the complement system by binding to the central component C3 and its fragments C3b and C3c. A combination of theoretical and experimental approaches has previously allowed us to develop a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f6987de85cecac010c78d307cc9f2b
https://doi.org/10.1002/jmr.972

[Untitled]

Autor: You-Qiang Wu, Alicja Ziemienowicz, Barbara Hohn

Publikováno v: Plant Molecular Biology. 46:161-170

Here we report the purification and biochemical characterization of recombinant Arabidopsis thaliana DNA ligase I. We show that this ligase requires ATP as a source for adenylation. The calculated K m [ATP] for ligation is 3 μM. This enzyme is able

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9658c8b008c1bf25a55431451d07d647
https://doi.org/10.1023/a:1010679901911

A Molecular Insight into Complement Evasion by the Staphylococcal Complement Inhibitor Protein Family

Autor: Brian V. Geisbrecht, Georgia Sfyroera, Paul N. Barlow, V. Michael Holers, Daniel Ricklin, John D. Lambris, Apostolia Tzekou, You-Qiang Wu, William J. McWhorter, Brandon L. Garcia, Andrew P. Herbert, Michal Hammel

Publikováno v: Ricklin, D, Tzekou, A, Garcia, B L, Hammel, M, McWhorter, W J, Sfyroera, G, Wu, Y-Q, Holers, V M, Herbert, A P, Barlow, P N, Geisbrecht, B V & Lambris, J D 2009, ' A Molecular Insight into Complement Evasion by the Staphylococcal Complement Inhibitor Protein Family ', Journal of Immunology, vol. 183, no. 4, pp. 2565-2574 . https://doi.org/10.4049/jimmunol.0901443

Staphylococcus aureus possesses an impressive arsenal of complement evasion proteins that help the bacterium escape attack of the immune system. The staphylococcal complement inhibitor (SCIN) protein exhibits a particularly high potency and was previ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfaf4cdf38b8a1015ca6012d23321baf
https://www.pure.ed.ac.uk/ws/files/7508482/NIH_2009_Barlow.pdf