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Betaine acts on a ligand-gated ion channel in the nervous system of the nematode C. elegans

Autor: Erik M. Jorgensen, Vadivel Ganapathy, Guoliang Jiang, Kenneth J. Murfitt, Aude S. Peden, Eric A. Miska, Julian L. Griffin, You Jun Fei, Patrick Mac, Cecilia Castro

Publikováno v: Nature neuroscience

Prior to the advent of synthetic nematocides, natural products such as seaweed were used to control nematode infestations. The nematocidal agent in seaweed is betaine, an amino acid that functions as an osmolyte and methyl donor. However, the molecul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83e46b8497da77e9923c00146e5fa31
http://europepmc.org/articles/PMC3955162

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Interaction of Ibuprofen and Other Structurally Related NSAIDs with the Sodium-Coupled Monocarboxylate Transporter SMCT1 (SLC5A8)

Autor: Seiji Miyauchi, You Jun Fei, Lina Zhuang, Puttur D. Prasad, Elangovan Gopal, Shirou Itagaki, Vadivel Ganapathy

Publikováno v: Pharmaceutical Research. 23:1209-1216

Sodium-coupled monocarboxylate transporter 1 (SMCT1) is a Na+-coupled transporter for monocarboxylates. Many nonsteroidal anti-inflammatory drugs (NSAIDs) are monocarboxylates. Therefore, we investigated the interaction of these drugs with human SMCT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf266179dfcd3e5288e9d80fc66ae73a
https://doi.org/10.1007/s11095-006-0023-1

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Electrophysiological Characterization and Modeling of the Structure Activity Relationship of the Human Concentrative Nucleoside Transporter 3 (hCNT3)

Autor: Vadivel Ganapathy, H. Hu, Shirou Itagaki, Eun Woo Lee, Christopher J. Endres, Peter W. Swaan, You Jun Fei, Nagavedi S. Umapathy, Jashvant D. Unadkat, Cheng Chang

Publikováno v: Molecular Pharmacology. 69:1542-1553

We characterized the electrophysiology, kinetics, and quantitative structure-activity relationship (QSAR) of the human concentrative nucleoside transporter 3 (hCNT3) expressed in Xenopus laevis oocytes by measuring substrate-induced inward currents u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54089636183c7b9570fb06ec1405bcd2
https://doi.org/10.1124/mol.105.018945

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Expression of slc5a8 in Kidney and Its Role in Na+-coupled Transport of Lactate

Autor: Elangovan Gopal, Lina Zhuang, Puttur D. Prasad, Mitsuru Sugawara, You Jun Fei, Pamela M. Martin, Sylvia B. Smith, Vadivel Ganapathy, Seiji Miyauchi

Publikováno v: Journal of Biological Chemistry. 279:44522-44532

We report here on the expression of slc5a8 in kidney and its relevance to Na(+)-coupled reabsorption of lactate. slc5a8 is the murine ortholog of SLC5A8, a candidate tumor suppressor gene, which we recently cloned from human intestine and demonstrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22bb9180e2ceb83ca7c19fe2d04f9b1b
https://doi.org/10.1074/jbc.m405365200

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Transport of Amino Acid-Based Prodrugs by the Na+- and Cl--Coupled Amino Acid Transporter ATB0,+ and Expression of the Transporter in Tissues Amenable for Drug Delivery

Autor: Takahiro Hatanaka, Sylvia B. Smith, Preethi S. Ganapathy, You Jun Fei, Vadivel Ganapathy, Seiji Miyauchi, Christy C. Bridges, Malliga E. Ganapathy, Masayuki Haramura

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 308:1138-1147

We evaluated the potential of the Na(+)- and Cl(-)-coupled amino acid transporter ATB(0,+) as a delivery system for amino acid-based prodrugs. Immunofluorescence analysis indicated that ATB(0,+) is expressed abundantly on the luminal surface of cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784c2202e3e544ca203a4ef1bfadd038
https://doi.org/10.1124/jpet.103.057109

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Structure, function and immunolocalization of a proton‐coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco‐2

Autor: You-Jun Fei, Vadivel Ganapathy, Seiji Miyauchi, David T. Thwaites, Catriona M.H. Anderson, Wei Huang, Zhong Chen, Katherine A. Wake

Publikováno v: The Journal of Physiology. 546:349-361

Throughout the animal and plant kingdoms, amino acids play vital roles in a variety of essential biological functions, including protein synthesis, neurotransmission, nitrogen metabolism and cell growth. Many of these functions depend on the entry of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7783cdd9878a5a59670fc54f767df2f3
https://doi.org/10.1113/jphysiol.2002.026500

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Depressed Patients Have Higher Body Temperature: 5-HT Transporter Long Promoter Region Effects

Autor: N. Shendarkar, Jeffrey L. Rausch, You-Jun Fei, Katina M. Corley, Vadivel Ganapathy, F. H. Leibach, Maria E. Johnson, H.M. Hobby

Publikováno v: Neuropsychobiology. 47:120-127

Background: Depression has been associated with a decrease in intracellular serotonin (5-HT) reuptake through its transporter, SERT. The 5-HT transporter long promoter region (5-HTTLPR) deletion in the SERT gene has also been associated with a decrea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ecee6b7d3e2632011dab075596180c6
https://doi.org/10.1159/000070579

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Antidepressant effects on kinase gene expression patterns in rat brain

Autor: Vadivel Ganapathy, H.M. Hobby, C.F. Gillespie, You-Jun Fei, T. Stoming, F. H. Leibach, Jeffrey L. Rausch

Publikováno v: Neuroscience Letters. 334:91-94

Multiple kinase pathways determine serotonin transporter (SERT) regulation. We hypothesized a decrease in kinase expression with chronic selective serotonin reuptake inhibitor (SSRI) administration necessary to regulate extracellular serotonin. We st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0febe00ede25846d752696f3b7c12d26
https://doi.org/10.1016/s0304-3940(02)01106-0

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Cloning and Functional Characterization of a σ Receptor from Rat Brain

Autor: Vadivel Ganapathy, Frederick H. Leibach, Pankaj Seth, You-Jun Fei, Hui W. Li, Wei Huang

Publikováno v: Journal of Neurochemistry. 70:922-931

We have cloned a sigma receptor from rat brain and established its functional identity using a heterologous expression system. The cloned cDNA (1,582 bp long) codes for a protein of 223 amino acids that possesses a single putative transmembrane domai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a730f91a8c3da619398498fb07ad3af
https://doi.org/10.1046/j.1471-4159.1998.70030922.x

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Functional identity of Drosophila melanogaster Indy as a cation-independent, electroneutral transporter for tricarboxylic acid-cycle intermediates

Autor: Lina Zhuang, You-Jun Fei, Katsuhisa Inoue, Wei Huang, Vadivel Ganapathy, Zhong Chen

Publikováno v: Biochemical Journal. 367:313-319

Indy is a gene in Drosophila melanogaster which, when made dysfunctional, leads to an extension of the average adult life span of the organism. The present study was undertaken to clone the Indy gene-product and to establish its functional identity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065af6a42c1d46d40fb416edf94de7f1
https://doi.org/10.1042/bj20021132

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