Zobrazeno 1 - 7
of 7
pro vyhledávání: '"You-Chiun Chang"'
Autor:
You-Chiun Chang, 張佑群
104
Ribosomes are important machines for protein synthesis in all organisms. In the past 50 years, structures of the ribosome have been revealed by TEM, X-ray and cryo-EM. However, many aspects of the mechanism of how the ribosome translates mRN
Ribosomes are important machines for protein synthesis in all organisms. In the past 50 years, structures of the ribosome have been revealed by TEM, X-ray and cryo-EM. However, many aspects of the mechanism of how the ribosome translates mRN
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/46579538626402582758
Autor:
Wen-Ching Lin, Hao-Cheng Tang, Han Ying Wang, Chia-Yi Kao, You-Chiun Chang, Athena Hsu Li, Shi-Bing Yang, Kurt Yun Mou
Publikováno v:
ACS synthetic biology. 11(4)
Two fundamentally different approaches are routinely used for protein engineering: user-defined mutagenesis and random mutagenesis, each with its own strengths and weaknesses. Here, we invent a unique mutagenesis protocol, which combines the advantag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a9ffb9db138ed0144f1e15e29cb089
https://pubmed.ncbi.nlm.nih.gov/35324156
https://pubmed.ncbi.nlm.nih.gov/35324156
Publikováno v:
Journal of Proteome Research. 19:1109-1118
Proximity labeling (PL) and chemical cross-linking (XL) mass spectrometry are two powerful methods to dissect protein-protein interactions (PPIs) in cells. Although PL typically captures neighboring proteins within a range of 10-20 nm of a single bai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99438cada83fcb6a77a2de792d5cfa82
https://doi.org/10.1021/acs.jproteome.9b00609
https://doi.org/10.1021/acs.jproteome.9b00609
Publikováno v:
Mol Ther
Tumor necrosis factor α (TNF-α) is upregulated in a chronic inflammatory environment, including tumors, and has been recognized as a pro-tumor factor in many cancers. Applying the traditional TNF-α antibodies that neutralize TNF-α activity, howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de040453509b8d5cd8e2af45591a3735
https://pubmed.ncbi.nlm.nih.gov/35440418
https://pubmed.ncbi.nlm.nih.gov/35440418
Autor:
Yao-An Yu, Kurt Yun Mou, Che-Wei Hu, See-Khai Lim, You-Chiun Chang, Han Ying Wang, Chia-Yi Kao
Publikováno v:
ACS synthetic biology. 10(8)
Due to its highly immunogenic nature and the great engineerability, filamentous phage has shown promising antitumor activities in preclinical studies. Previous designs of antitumor phage mainly focused on tumor targeting using a cancer-specific moiet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc6c919fc30fc020bf643fa7e4a04941
https://pubmed.ncbi.nlm.nih.gov/34342970
https://pubmed.ncbi.nlm.nih.gov/34342970
Publikováno v:
Biochemistry. 59(44)
Traditional antibody generation, using either phage display or animal immunization, relies on purified antigens. Many membrane proteins, such as G protein-coupled receptors, solute carriers, or ion channels, are important drug targets but very challe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36600c28a863b1db09958a2df5bb2165
https://pubmed.ncbi.nlm.nih.gov/33118810
https://pubmed.ncbi.nlm.nih.gov/33118810
Publikováno v:
Journal of molecular medicine (Berlin, Germany). 98(12)
Inflammatory bowel disease is a lifelong disorder that involves chronic inflammation in the small and large intestines. Current therapies, including aminosalicylates, corticosteroids, and anti-inflammatory biologics, can only alleviate the symptoms a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0111d3f39ac614a983e536f9922b20cb
https://pubmed.ncbi.nlm.nih.gov/33025105
https://pubmed.ncbi.nlm.nih.gov/33025105