Zobrazeno 1 - 10
of 59
pro vyhledávání: '"You Zhuo"'
Autor:
Florence N. Reddish, Cassandra L. Miller, Xiaonan Deng, Bin Dong, Atit A. Patel, Mohammad A. Ghane, Barbara Mosca, Cheyenne McBean, Shengnan Wu, Kyril M. Solntsev, You Zhuo, Giovanni Gadda, Ning Fang, Daniel N. Cox, Angela M. Mabb, Susan Treves, Francesco Zorzato, Jenny J. Yang
Publikováno v:
iScience, Vol 24, Iss 3, Pp 102129- (2021)
Summary: The precise spatiotemporal characteristics of subcellular calcium (Ca2+) transients are critical for the physiological processes. Here we report a green Ca2+ sensor called “G-CatchER+” using a protein design to report rapid local ER Ca2+
Externí odkaz:
https://doaj.org/article/4c7e2bf541984ca7a973495876649783
Autor:
Deyun Wang, You Zhuo, Mike Karfunkle, Sharadrao M. Patil, Cameron J. Smith, David A. Keire, Kang Chen
Publikováno v:
Molecules, Vol 26, Iss 14, p 4251 (2021)
Peptide and protein drug molecules fold into higher order structures (HOS) in formulation and these folded structures are often critical for drug efficacy and safety. Generic or biosimilar drug products (DPs) need to show similar HOS to the reference
Externí odkaz:
https://doaj.org/article/0e8386945d20489ea9b1a4234113e6b6
Akademický článek
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Autor:
Xin-Qiu Yao, Ning Fang, Angela M. Mabb, Zheng Zachory Wei, Daniel Ouedraogo, Giovanni Gadda, You Zhuo, Ken Berglund, Bin Dong, Cheyenne McBean, Xiaonan Deng, Shan Ping Yu, Jenny J. Yang, Samer Gozem, Mohammad A Ghane, Ling Wei, Donald Hamelberg
Publikováno v:
Angewandte Chemie. 133:23477-23486
Multi-scale calcium (Ca2+ ) dynamics, exhibiting wide-ranging temporal kinetics, constitutes a ubiquitous mode of signal transduction. We report a novel endoplasmic-reticulum (ER)-targeted Ca2+ indicator, R-CatchER, which showed superior kinetics in
Akademický článek
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Publikováno v:
In Thermochimica Acta 10 February 2013 553:54-59
Publikováno v:
Molecular Pharmaceutics. 18:441-450
The N-glycosylation pattern of Asn-297 may have impacts on monoclonal antibody (mAb) drug plasma clearance, antibody-dependent cell mediated cytotoxicity (ADCC), and complement-dependent cytotoxicity (CDC). Notably, the changes in the relative abunda
Autor:
Diana Y. Lee, Christopher M. Bergeron, Richard G. Spencer, Mustapha Bouhrara, Wenshu Qian, Abinand C. Rejimon, You Zhuo
Publikováno v:
Magnetic Resonance Imaging. 53:173-179
Purpose To extend the null signal method (NSM) for B1 mapping to 3 T magnetic resonance imaging (MRI). Background The NSM operates in the steady state regime and exploits the linearity of the spoiled gradient recalled echo (SPGR) signal around the 18
Autor:
Giovanni Gadda, Kyril M. Solntsev, Bin Dong, Cassandra Lynn Miller, Angela M. Mabb, Atit A. Patel, Xiaonan Deng, Ning Fang, Cheyenne McBean, Mohammad A Ghane, Daniel N. Cox, Susan Treves, Jenny J. Yang, Barbara Mosca, Florence Reddish, Francesco Zorzato, You Zhuo, Shengnan Wu
Publikováno v:
iScience
iScience, Vol 24, Iss 3, Pp 102129-(2021)
iScience, Vol 24, Iss 3, Pp 102129-(2021)
Summary The precise spatiotemporal characteristics of subcellular calcium (Ca2+) transients are critical for the physiological processes. Here we report a green Ca2+ sensor called “G-CatchER+” using a protein design to report rapid local ER Ca2+
Autor:
John R. Hepler, Yanyi Chen, Nicole E. Brown, Jenny J. Yang, Mani Salarian, Juan Zou, You Zhuo
Publikováno v:
Biochemical Journal. 474:4035-4051
Calmodulin (CaM) is an intracellular Ca 2+ transducer involved in numerous activities in a broad Ca 2+ signaling network. Previous studies have suggested that the Ca 2+ /CaM complex may participate in gap junction regulation via interaction with puta