Zobrazeno 1 - 10
of 155
pro vyhledávání: '"You Tang Shen"'
Autor:
David Ho, Li Chen, Xin Zhao, Nicquanna Durham, Malar Pannirselvam, Dorothy E Vatner, David J Morgans, Fady I Malik, Stephen F Vatner, You-Tang Shen
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36302 (2012)
Pulmonary hypertension remains a major clinical problem despite current therapies. In this study, we examine for the first time a novel pharmacological target, smooth muscle myosin, and determine if the smooth muscle myosin inhibitor, CK-2019165 (CK-
Externí odkaz:
https://doaj.org/article/19f0f2d84641463c8d31ccc641c431cb
Autor:
Zhe Sun, Gerald A. Meininger, Tara McNulty, Sanford P. Bishop, Li Chen, Dorothy E. Vatner, Jie Zhang, You-Tang Shen, Stephen F. Vatner, Xin Zhao
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 36:700-706
Objective— Increased vascular stiffness is central to the pathophysiology of aging, hypertension, diabetes mellitus, and atherosclerosis. However, relatively few studies have examined vascular stiffness in both the thoracic and the abdominal aorta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35ed874d7bcf5057242d8267aba15b0
https://doi.org/10.1161/atvbaha.115.306563
https://doi.org/10.1161/atvbaha.115.306563
With advances in molecular and genomic research offering novel insights into cardiovascular diseases, recently many transgenic animal models have been developed and characterized. Currently, more than 90% of all laboratory animals are mice and rats.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acbea51116dabbb85ac0226522af5642
https://doi.org/10.1016/b978-0-12-809468-6.00006-1
https://doi.org/10.1016/b978-0-12-809468-6.00006-1
Autor:
Bernhard Aigner, W. Ted Allison, Roberto Andreatini, Marta Antonelli, Saskia S. Arndt, Amazon Austin, Cristin Brand, Joanna Bukowska, Andrew C. Caprariello, Rachel E. Carlisle, Lucas M. Chaible, Li Chen, Mengqi Chen, Thomas Chi, Mohammed E. Choudhury, Iain J. Clarke, Kristine Coleman, Gabriela D. Colpo, Oliver S. Damm, Catherine M. Davis, Erica E. Davis, Luis de Lecea, Aline S. de Miranda, Diogo B. de Souza, Jeffrey G. Dickhout, Paul J. Donaldson, Geoffrey A. Donnan, Yuko Emoto, David Feifel, Marcus A. Finzi Corat, Martin G. Frasch, Ryutaro Fukumura, Toshio Fukusato, John-Paul Fuller-Jackson, Sharyl Fyffe-Maricich, Barbara Gawronska-Kozak, Godfrey S. Getz, Yoichi Gondo, Belinda A. Henry, David W. Howells, Sumit Jamwal, Jiro Kasahara, Nicholas Katsanis, Matthew W. Kemp, Barbara Kessler, Imran Khan, Aileen King, Denise Kinoshita, Nikolai Klymiuk, Ryuta Koyama, Doris Kretzschmar, Puneet Kumar, Jitka Kuncova, Maki Kuro, Mayuko Kurome, Michael Lardelli, Heather A. Lawson, Lars Lewejohann, Julie C. Lim, David M. Lyons, Malcolm R. Macleod, Shigeru Makino, Marta Martinez-Lage, Renita M. Martis, Ellen Meijer, Gerlinde A.S. Metz, Robert H. Miller, Yuichiro Miura, Zahraa Mohammed-Ali, Gabrielle C. Musk, Samera Nademi, Aysegul Nalca, Morgan Newman, Yu Nie, Noriko Nishikawa, Masahiro Nomoto, Rebecca E. Nordquist, Victoria E. O’Collins, Masatoshi Ogawa, Marco A. Pereira-Sampaio, Jean-Paul Praud, João Quevedo, Catherine A. Reardon, Christopher P. Regan, Simone Renner, Fabiola M. Ribeiro, Natalia P. Rocha, Sandra Rodriguez-Perales, Sara I. Ruiz, Masatoshi Saito, Francisco J.B. Sampaio, Steven J. Schapiro, Alan F. Schatzberg, Jay Schulkin, Angela L. Shamchuk, Richard P. Shannon, You-Tang Shen, Paul D. Shilling, Milan Stengl, Marshall L. Stoller, Stephen R. Stürzenbaum, Jitka Sviglerova, Kazumi Taguchi, Yoshihisa Takahashi, Akie Tanabe, Junya Tanaka, Jerrold Tannenbaum, Antônio L. Teixeira, Jeffrey M. Testani, Keith B. Tierney, Raul Torres-Ruiz, Airo Tsubura, Ryosuke Tsuji, David T. Tzou, Haruo Usuda, Samira S. Valvassori, Franz J. van der Staay, Roger B. Varela, Giuseppe Verdile, Irene Vorontsova, Jessica P. Wayhart, James L. Weed, JoEllen Welsh, Steffi Werler, Joachim Wistuba, Eckhard Wolf, Annegret Wünsch, Toshiyuki Yamamoto, Hironori Yokoyama, Katsuhiko Yoshizawa, Maria L. Zaidan Dagli, Jennifer Y. Zhang, Yu Zhou, Elizabeth E. Zumbrun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c10440a25dcbbfc031ebf261231febdd
https://doi.org/10.1016/b978-0-12-809468-6.00048-6
https://doi.org/10.1016/b978-0-12-809468-6.00048-6
Autor:
Xin Zhao, Stephen F. Vatner, You-Tang Shen, Christophe Depre, Dorothy E. Vatner, Xiangzhen Sui, Paulo Lizano, Sunil K. Dhar, Li Chen
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 300:H1303-H1310
The second window of ischemic preconditioning (SWOP) provides maximal protection against ischemia through regulation of the inducible nitric oxide synthase (iNOS), yet its application is limited by the inconvenience of the preliminary ischemic stimul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73037b6f78787a4b1dc658e6a3c850fe
https://doi.org/10.1152/ajpheart.00979.2010
https://doi.org/10.1152/ajpheart.00979.2010
Autor:
Katjuša Brejc, Jeffrey T. Finer, Maria Pokrovskii, David R. Cox, Daniel W. Pierce, Marc Garard, Ramesh Baliga, Congrong Niu, Todd Tochimoto, Kathleen A. Elias, Guillermo Godinez, Stephen F. Vatner, You Tang Shen, Roman Sakowicz, Bradley P. Morgan, Sandra H. Sueoka, Pu Ping Lu, Fady I. Malik, Tatsuo Katori, Alexander Muci, David Lenzi, David J. Morgans, Corey Valdez, Sheila Sylvester, Kenneth Lee, Xiangping Qian, Ion Suehiro, Erica Kraynack, Raja Kawas, David A. Kass, James J. Hartman, Hector P. Rodriguez, Robert L. Anderson, Wenyue Wang
Publikováno v:
Science. 331:1439-1443
Decreased cardiac contractility is a central feature of systolic heart failure. Existing drugs increase cardiac contractility indirectly through signaling cascades but are limited by their mechanism-related adverse effects. To avoid these limitations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b655534b7d4dbf40b4a85dea7dd873d
https://doi.org/10.1126/science.1200113
https://doi.org/10.1126/science.1200113
Autor:
You-Tang Shen, Li Chen, Anjali V. Fields, Shiva Bhashyam, Brandy Patterson, Jeffrey M. Testani, Richard P. Shannon
Publikováno v:
Circulation: Heart Failure. 3:512-521
Background— We have shown that glucagon-like peptide-1 (GLP-1[7–36] amide) stimulates myocardial glucose uptake in dilated cardiomyopathy (DCM) independent of an insulinotropic effect. The cellular mechanisms of GLP-1–induced myocardial glucose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55ffbb29fda076f4f8a0963fe870ffd3
https://doi.org/10.1161/circheartfailure.109.900282
https://doi.org/10.1161/circheartfailure.109.900282
Autor:
Changgong Wu, Dorothy E. Vatner, You-Tang Shen, Junichi Sadoshima, Stephen F. Vatner, Sunil K. Dhar, Christophe Depre, Lin Yan
Publikováno v:
American Journal of Physiology-Cell Physiology. 297:C928-C934
Cytochrome c oxidase (COX) is composed of 13 subunits, of which COX I, II, and III are encoded by a mitochondrial gene. COX I and II function as the main catalytic components, but the function of COX III is unclear. Because myocardial ischemia affect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6e2eb001775601225eb1bf9fffc932
https://doi.org/10.1152/ajpcell.00045.2009
https://doi.org/10.1152/ajpcell.00045.2009
Autor:
Misun Park, Guy R. Heyndrickx, Vinciane Gaussin, Jozef Bartunek, Ranillo R.G. Resuello, Dorothy E. Vatner, Stephen F. Vatner, You-Tang Shen, Filipinas F. Natividad, Richard N. Kitsis
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 297:H785-H791
The goal of this investigation was to determine the distribution of myocardial apoptosis in myocytes and nonmyocytes in primates and patients with heart failure (HF). Almost all clinical cardiologists and cardiovascular investigators believe that myo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f264ed8c48a1e6208c83986520a79164
https://doi.org/10.1152/ajpheart.00310.2009
https://doi.org/10.1152/ajpheart.00310.2009
Autor:
Ranillo R.G. Resuello, Filipinas F. Natividad, Franco Rossi, Yimin Tian, Athanasios Peppas, Dorothy E. Vatner, Xiao-Ping Zhang, Stephen F. Vatner, You-Tang Shen
Publikováno v:
Journal of Molecular and Cellular Cardiology. 43:487-491
We studied gender-specific changes in aging cardiomyopathy in a primate model, Macaca fascicularis, free of the major human diseases, complicating the interpretation of data specific to aging in humans. Left ventricular (LV) weight/body weight decrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36cc693337db6bb615ec5f1f76d0fa6b
https://doi.org/10.1016/j.yjmcc.2007.07.048
https://doi.org/10.1016/j.yjmcc.2007.07.048