Zobrazeno 1 - 10
of 52
pro vyhledávání: '"You Take Oh"'
Autor:
Jian Wang, You-Take Oh, Zhentian Li, Juan Dou, Siyuan Tang, Xiang Wang, Hongyan Wang, Shunichi Takeda, Ya Wang
Publikováno v:
Cell Reports, Vol 34, Iss 2, Pp 108625- (2021)
Summary: Radiation sensitive 52 (RAD52) is an important factor for double-strand break repair (DSBR). However, deficiency in vertebrate/mammalian Rad52 has no apparent phenotype. The underlying mechanism remains elusive. Here, we report that RAD52 de
Externí odkaz:
https://doaj.org/article/b5cfdca9370c4176a775051793a4c514
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract b-AP15 and its derivatives block proteasome deubiquitinase (DUB) activity and have been developed and tested in the clinic as potential cancer therapeutic agents. b-AP15 induces apoptosis in cancer cells, but the underlying mechanisms are la
Externí odkaz:
https://doaj.org/article/38f8016a0030447e8e7e8736ee71973b
Publikováno v:
Cell Communication and Signaling, Vol 15, Iss 1, Pp 1-10 (2017)
Abstract Background Death receptor (DR5), a well-characterized death domain-containing cell surface pro-apoptotic protein, has been suggested to suppress cancer cell invasion and metastasis. However, the underlying mechanisms have not been fully eluc
Externí odkaz:
https://doaj.org/article/47f8e3626b0b422bb0edf2668ace2891
Autor:
Shi-Yong Sun, Mingwei Chen, Taofeek K. Owonikoko, Suresh S. Ramalingam, Emily Anderson, Benjamin Legendre, Grant Wu, Hui Ren, Shuo Zhang, Guoqing Qian, Guojing Zhang, Liang Deng, You-Take Oh, Puyu Shi
The combination of AZD9291 with a MEK inhibitor effectively induces apoptosis in AZD9291-resistant NSCLC cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2847a338451e082874993892dd3ff74d
https://doi.org/10.1158/1078-0432.22468614
https://doi.org/10.1158/1078-0432.22468614
Autor:
Shi-Yong Sun, Mingwei Chen, Taofeek K. Owonikoko, Suresh S. Ramalingam, Emily Anderson, Benjamin Legendre, Grant Wu, Hui Ren, Shuo Zhang, Guoqing Qian, Guojing Zhang, Liang Deng, You-Take Oh, Puyu Shi
Purpose: The mechanisms accounting for anticancer activity of AZD9291 (osimertinib or TAGRISSO), an approved third-generation EGFR inhibitor, in EGFR-mutant non–small cell lung cancer (NSCLC) cells and particularly for the subsequent development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4c4bca9f4bca8d6a0e1293ea696e35
https://doi.org/10.1158/1078-0432.c.6527013.v1
https://doi.org/10.1158/1078-0432.c.6527013.v1
Autor:
You-Take Oh, Shi-Yong Sun
Publikováno v:
Biomolecules, Vol 11, Iss 4, p 499 (2021)
Death ligands such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL; TNFSF10) and their corresponding death receptors (e.g., DR5) not only initiate apoptosis through activation of the extrinsic apoptotic pathway but also exert non-ap
Externí odkaz:
https://doaj.org/article/49378c43c32c49f982702404dc11a9f9
Publikováno v:
Apoptosis. 26:338-347
Caspase-mediated cleavage of proteins ensures the irreversible commitment of cells to undergo apoptosis, and is thus a hallmark of apoptosis. Rapamycin-insensitive companion of mTOR (rictor) functions primarily as a core and essential component of mT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f55f8bb0d5039b6f7dbd44d21988fa2d
https://doi.org/10.1007/s10495-021-01676-y
https://doi.org/10.1007/s10495-021-01676-y
Autor:
Liangfang Shen, Bailong Liu, You-Take Oh, Zhentian Li, Min Liu, Jian Wang, Ya Wang, Siyuan Tang, Jiaqi Liu, Hongyan Wang
Publikováno v:
DNA Repair. 78:37-44
DNA double strand breaks (DSBs) are a severe threat to genome integrity and a potential cause of tumorigenesis, which is a multi-stage process and involves many factors including the mutation of oncogenes and tumor suppressors, some of which are tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2bfbd12770982cd2203f65ea00db367
https://doi.org/10.1016/j.dnarep.2019.03.012
https://doi.org/10.1016/j.dnarep.2019.03.012
Publikováno v:
Apoptosis : an international journal on programmed cell death. 26(5-6)
Caspase-mediated cleavage of proteins ensures the irreversible commitment of cells to undergo apoptosis, and is thus a hallmark of apoptosis. Rapamycin-insensitive companion of mTOR (rictor) functions primarily as a core and essential component of mT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::40844bd40e99c92fdb89cbdff4a0189d
https://pubmed.ncbi.nlm.nih.gov/33905036
https://pubmed.ncbi.nlm.nih.gov/33905036
Autor:
Wei Zhou, Ping Yue, Taofeek K. Owonikoko, Esther P. Black, Shi-Yong Sun, Justin M. Balko, Fadlo R. Khuri, You-Take Oh
Publikováno v:
J Biol Chem
Oncogenic mutations of ras and B-raf frequently occur in many cancer types and are critical for cell transformation and tumorigenesis. Death receptor 5 (DR5) is a cell surface pro-apoptotic death receptor for tumor necrosis factor-related apoptosis-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8aa91d68ab70b5a1987a3072c41d0e7
https://europepmc.org/articles/PMC7324490/
https://europepmc.org/articles/PMC7324490/