Zobrazeno 1 - 10
of 173
pro vyhledávání: '"You Mie Lee"'
Autor:
Hye-Jin Boo, Hye-Young Min, Su Jung Hwang, Hyo-Jong Lee, Jae-Won Lee, Sei-Ryang Oh, Choon-Sik Park, Jong-Sook Park, You Mie Lee, Ho-Young Lee
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 6, Pp 1131-1144 (2023)
Abstract The renin-angiotensin (RA) system has been implicated in lung tumorigenesis without detailed mechanistic elucidation. Here, we demonstrate that exposure to the representative tobacco-specific carcinogen nitrosamine 4-(methylnitrosamino)-1-(3
Externí odkaz:
https://doaj.org/article/dc30c8eff1d24fa5b014bc318d4499e6
Publikováno v:
The Korean Journal of Gastroenterology, Vol 79, Iss 4, Pp 170-176 (2022)
Background/Aims: Angiogenesis is essential for the outgrowth and metastasis of tumors. The structure and characteristics of tumor vasculature differ from those of normal vessels. We compared the characteristics of differentially expressed genes in en
Externí odkaz:
https://doaj.org/article/8ff6838bc73d4218bd0e1dbe472f6b34
Autor:
Young Sun Choi, Hyeonha Jang, Biki Gupta, Ji-Hak Jeong, Yun Ge, Chul Soon Yong, Jong Oh Kim, Jong-Sup Bae, Im-Sook Song, In-San Kim, You Mie Lee
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-18 (2020)
Abstract Background Conventional therapeutic approaches for tumor angiogenesis, which are primarily focused on the inhibition of active angiogenesis to starve cancerous cells, target the vascular endothelial growth factor signaling pathway. This aggr
Externí odkaz:
https://doaj.org/article/db80f33a15cc4fada2f1b9246ca794b9
Autor:
Heeyoun Bunch, Jaehyeon Jeong, Keunsoo Kang, Doo Sin Jo, Anh T. Q. Cong, Deukyeong Kim, Donguk Kim, Dong-Hyung Cho, You Mie Lee, Benjamin P. C. Chen, Matthew J. Schellenberg, Stuart K. Calderwood
Publikováno v:
Open Biology, Vol 11, Iss 10 (2021)
RNA polymerase II (Pol II)-dependent transcription in stimulus-inducible genes requires topoisomerase IIβ (TOP2B)-mediated DNA strand break and the activation of DNA damage response signalling in humans. Here, we report a novel function of the breas
Externí odkaz:
https://doaj.org/article/6d84432b1b6c4245b6debb21f48be0c7
Autor:
You Mie Lee
Publikováno v:
Cells, Vol 11, Iss 19, p 3098 (2022)
The tumor microenvironment (TME) is broadly implicated in tumorigenesis, as tumor cells interact with surrounding cells to influence the development and progression of the tumor. Blood vessels are a major component of the TME and are attributed to th
Externí odkaz:
https://doaj.org/article/99f8fe41ae9e4994949a93fced54c452
Autor:
Jun-Kyu Byun, Yeon-Kyung Choi, Ji-Hyun Kim, Ji Yun Jeong, Hui-Jeon Jeon, Mi-Kyung Kim, Ilseon Hwang, Shin-Yup Lee, You Mie Lee, In-Kyu Lee, Keun-Gyu Park
Publikováno v:
Cell Reports, Vol 20, Iss 3, Pp 586-599 (2017)
Proper regulation of mTORC1 and mTORC2 upon nutrient starvation is critical for cancer cell survival. Upregulation of Sestrin2 in response to glutamine deprivation rescues cell death by suppressing mTORC1. However, the contribution of mTORC2 to Sestr
Externí odkaz:
https://doaj.org/article/9515e654db7b4ff09beddd5322bcf9dd
Autor:
Myo-Hyeon Park, Ae kyung Kim, Sarala Manandhar, Su-Young Oh, Gun-Hyuk Jang, Li Kang, Dong-Won Lee, Do Young Hyeon, Sun-Hee Lee, Hye Eun Lee, Tae-Lin Huh, Sang Heon Suh, Daehee Hwang, Kyunghee Byun, Hae-Chul Park, You Mie Lee
Publikováno v:
eLife, Vol 8 (2019)
CCN1 (CYR61) stimulates active angiogenesis in various tumours, although the mechanism is largely unknown. Here, we report that CCN1 is a key regulator of endothelial tip cell activity in angiogenesis. Microvessel networks and directional vascular ce
Externí odkaz:
https://doaj.org/article/9313d1d5b6ea490d9a7bab455bc9aff9
Clinical significance and prognostic role of hypoxia-induced microRNA 382 in gastric adenocarcinoma.
Autor:
An Na Seo, Yukdong Jung, Hyeonha Jang, Eunhye Lee, Han-Ik Bae, Taekwon Son, Ohkyung Kwon, Ho Young Chung, Wansik Yu, You Mie Lee
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223608 (2019)
Hypoxia and angiogenesis are critical components in the progression of solid cancer, including gastric cancers (GCs). miR-382 has been identified as a hypoxia-induced miR (hypoxamiR), but the clinical significance in GCs has not been identified yet.
Externí odkaz:
https://doaj.org/article/b1a82c4456ab4dfeadb34aad0380bf83
Publikováno v:
Molecules, Vol 23, Iss 8, p 1880 (2018)
Inflammation is considered the root cause of various inflammatory diseases, including cancers. Decursinol angelate (DA), a pyranocoumarin compound obtained from the roots of Angelica gigas, has been reported to exhibit potent anti-inflammatory effect
Externí odkaz:
https://doaj.org/article/8b23c5d3675b4ae79c0a83462eff96f0
Autor:
You Mie Lee, Sun-Hee Lee, Kheun Byeol Lee, Minh Phuong Nguyen, Min-Young Lee, Gyu Hwan Park, Mi Jeong Kwon
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84520 (2013)
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK, a tumor suppressor) is down-regulated by the oncogenic signals and hypoxia, but the biological function of RECK in early tumorigenic hyperplastic phenotypes is largely unknown. Knockdo
Externí odkaz:
https://doaj.org/article/392911682a394d30816d9eb5a5b28bed