Zobrazeno 1 - 10
of 1 913
pro vyhledávání: '"You LU"'
Publikováno v:
BMC Pediatrics, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Iron deficiency (ID) is the most prevalent nutritional deficiency disease in preterm infants, significantly affecting their growth and development. For preterm infants to flourish physically and neurologically, timely iron supplem
Externí odkaz:
https://doaj.org/article/947d3f817d384e7b947c5c9daf077371
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Background There is inconclusive evidence to suggest that the expression of programmed cell death ligand 1 (PD-L1) is a putative predictor of response to EGFR-TKI therapy in advanced EGFR-mutant non-small cell lung cancer (NSCLC). We evaluat
Externí odkaz:
https://doaj.org/article/c03f36fead7d4b4396e056a6740768cd
Autor:
Nanhao Yin, Xintong Li, Xuanwei Zhang, Shaolong Xue, Yu Cao, Gabriele Niedermann, You Lu, Jianxin Xue
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-50 (2024)
Abstract Immunotherapy represented by anti-PD-(L)1 and anti-CTLA-4 inhibitors has revolutionized cancer treatment, but challenges related to resistance and toxicity still remain. Due to the advancement of immuno-oncology, an increasing number of nove
Externí odkaz:
https://doaj.org/article/16b1901039d0420db4a3a0620183c418
Publikováno v:
Alexandria Engineering Journal, Vol 94, Iss , Pp 104-119 (2024)
Combining inertial navigation system (INS) and ultra-wideband (UWB) technologies can effectively compensate for their respective shortcomings, thus significantly enhancing the accuracy of indoor positioning systems. However, in the process of fusing
Externí odkaz:
https://doaj.org/article/189dd05eafe1427bb002d0702f7fc56a
Autor:
Caicun Zhou, MD, PhD, You Lu, MD, Sang-We Kim, MD, PhD, Thanyanan Reungwetwattana, MD, Jianying Zhou, MD, Yiping Zhang, MD, Jianxing He, MD, PhD, Jin-Ji Yang, MD, Ying Cheng, MD, Se-Hoon Lee, MD, PhD, Jianhua Chang, MD, Jian Fang, MD, Zhe Liu, PhD, Lilian Bu, MSc, Li Qian, MD, Tingting Xu, MD, Venice Archer, MB ChB, MSc, Magalie Hilton, MSc, Mingzhu Zhou, MSc, Li Zhang, MD
Publikováno v:
JTO Clinical and Research Reports, Vol 5, Iss 9, Pp 100700- (2024)
Introduction: Previous results from the phase 3 ALESIA study (NCT02838420) revealed that alectinib (a central nervous system [CNS]-active, ALK inhibitor) had clinical benefits in treatment-naïve Asian patients with advanced ALK-positive NSCLC, consi
Externí odkaz:
https://doaj.org/article/0adb5b401a534eba8c323105cdaa5a38
Autor:
Liangguang Leo Lin, Huilun Helen Wang, Brent Pederson, Xiaoqiong Wei, Mauricio Torres, You Lu, Zexin Jason Li, Xiaodan Liu, Hancheng Mao, Hui Wang, Linyao Elina Zhou, Zhen Zhao, Shengyi Sun, Ling Qi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The SEL1L-HRD1 protein complex represents the most conserved branch of endoplasmic reticulum (ER)-associated degradation (ERAD). Despite recent advances in both mouse models and humans, in vivo evidence for the importance of SEL1L in the ERA
Externí odkaz:
https://doaj.org/article/014892729fb04bc09af72c00d188ae38
Autor:
Wei Chen, Yun Lu, Yan Zhang, Jinjin Wu, Abigail McVicar, Yilin Chen, Siyu Zhu, Guochun Zhu, You Lu, Jiayang Zhang, Matthew McConnell, Yi-Ping Li
Publikováno v:
eLife, Vol 13 (2024)
As the most common degenerative joint disease, osteoarthritis (OA) contributes significantly to pain and disability during aging. Several genes of interest involved in articular cartilage damage in OA have been identified. However, the direct causes
Externí odkaz:
https://doaj.org/article/937ac78055f34e0e8653a0c08025e07a
Autor:
Xiaoqiong Wei, You Lu, Liangguang Leo Lin, Chengxin Zhang, Xinxin Chen, Siwen Wang, Shuangcheng Alivia Wu, Zexin Jason Li, Yujun Quan, Shengyi Sun, Ling Qi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Endoplasmic reticulum-associated degradation (ERAD) plays indispensable roles in many physiological processes; however, the nature of endogenous substrates remains largely elusive. Here we report a proteomics strategy based on the intrinsic
Externí odkaz:
https://doaj.org/article/9af861f4006a4bc58054198a6fb20fa2
Autor:
Xianyan Chen, Xiaoman Tian, Xuanwei Zhang, Qianyue Deng, Min Wang, Xiaojuan Zhou, Yong Xu, Lin Zhou, Bingwen Zou, Yongmei Liu, Rui Ao, You Lu, Youling Gong
Publikováno v:
Thoracic Cancer, Vol 14, Iss 27, Pp 2735-2744 (2023)
Abstract Background The immune system may influence prognosis, and lymphopenia is a frequent side effect of concurrent chemoradiotherapy (CCRT). Radical irradiation for locally advanced esophageal cancer (LA‐EC) exposes significant vascular and hea
Externí odkaz:
https://doaj.org/article/6095fd7e82e24ec9be847cad5e39d17a
Autor:
Shuangcheng Alivia Wu, Chenchen Shen, Xiaoqiong Wei, Xiawei Zhang, Siwen Wang, Xinxin Chen, Mauricio Torres, You Lu, Liangguang Leo Lin, Huilun Helen Wang, Allen H. Hunter, Deyu Fang, Shengyi Sun, Magdalena I. Ivanova, Yi Lin, Ling Qi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Endoplasmic reticulum (ER)-associated degradation (ERAD) and ER-phagy are two principal degradative mechanisms for ER proteins and aggregates, respectively; however, the crosstalk between these two pathways under physiological settings remai
Externí odkaz:
https://doaj.org/article/55b8edfe9e8d440db2033fcd22bb16d0