Zobrazeno 1 - 10
of 308
pro vyhledávání: '"You Han Bae"'
Publikováno v:
Advanced Science, Vol 9, Iss 21, Pp n/a-n/a (2022)
Abstract Bile acid‐modified nanoparticles provide a convenient strategy to improve oral bioavailability of poorly permeable drugs by exploiting specific interactions with bile acid transporters. However, the underlying mechanisms are unknown, espec
Externí odkaz:
https://doaj.org/article/a3cea923e6d7410c91c3a94044dbf478
Autor:
Ying Han, Zhonggao Gao, Liqing Chen, Lin Kang, Wei Huang, Mingji Jin, Qiming Wang, You Han Bae
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 902-922 (2019)
In last few years, therapeutic peptides/proteins are rapidly growing in drug market considering their higher efficiency and lower toxicity than chemical drugs. However, the administration of therapeutic peptides/proteins is mainly limited in parenter
Externí odkaz:
https://doaj.org/article/3d8452e6d6e542bb8440aa53902f9ea9
Publikováno v:
Advanced healthcare materials. 11(21)
Here, antigen and adjuvant encapsulated dendritic cell-targeted nanoparticles for immune activation in the small intestinal lymphatic system to inhibit melanoma development are described. This strategy is demonstrated using chondroitin sulfate-coated
Autor:
Youqing Shen, You Han Bae
Publikováno v:
Advanced Drug Delivery Reviews. 194:114707
Autor:
Feiyang, Deng, You Han, Bae
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 48:102629
Bile acid-modified nanomedicine is a promising strategy to improve oral bioavailability. However, the efficiencies of different bile acids have not been clarified. To clarify this issue, deoxycholic acid (DCA) and cholic acid (CA) and glycocholic aci
Publikováno v:
Molecular Pharmaceutics. 17:4346-4353
Here, we describe the absorption pathways of nanoparticles whose surface is modified with bile acid and present environmental factors that influence oral bioavailability (BA) from the gastrointestinal tract (GIT). The approach utilized 100 nm sized f
Autor:
You Han Bae, Kinam Park
Publikováno v:
Adv Drug Deliv Rev
Drug delivery systems are developed to maximize drug efficacy and minimize side effects. As drug delivery technologies improve, the drug becomes safer and more comfortable for patients to use. During the last seven decades, extraordinary progress has
Autor:
Feiyang Deng, You Han Bae
Publikováno v:
Int J Pharm
Bile acid transporter-targeting has been proven to be an effective strategy to improve drug delivery to hepatocytes and enterocytes. With increasing discoveries of bile acid transporter expression on tumor cells, bile acid-modified anticancer drugs a
Autor:
Rui Sun, Jiajia Xiang, Quan Zhou, Ying Piao, Jianbin Tang, Shiqun Shao, Zhuxian Zhou, You Han Bae, Youqing Shen
Publikováno v:
Advanced Drug Delivery Reviews. 191:114614
Over the past three decades, the enhanced permeability and retention (EPR) effect has been considered the basis of tumor-targeted drug delivery. Various cancer nanomedicines, including macromolecular drugs, have been designed to utilize this mechanis
Autor:
Sungpil Cho, Hongsuk Park, Elke A Jarboe, C Matthew Peterson, You Han Bae, Margit M Janát-Amsbury
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141172 (2015)
Cancer stem cells (CSCs) are a small subset of cancer cells responsible for maintenance and progression of several types of cancer. Isolation, propagation, and the differentiation of CSCs in the proper stem niches expose the intrinsic difficulties fo
Externí odkaz:
https://doaj.org/article/427b683983404797b6740707f21f4503