Zobrazeno 1 - 10
of 151
pro vyhledávání: '"You‐Yang Zhao"'
Autor:
Luyang Cao, Lixiang Ma, Juan Zhao, Xiangyu Wang, Xinzou Fang, Wei Li, Yawen Qi, Yingkui Tang, Jieya Liu, Shengxian Peng, Li Yang, Liangxue Zhou, Li Li, Xiaobo Hu, Yuan Ji, Yingyong Hou, Yi Zhao, Xianming Zhang, You-yang Zhao, Yong Zhao, Yuquan Wei, Asrar B Malik, Hexige Saiyin, Jingsong Xu
Publikováno v:
eLife, Vol 12 (2023)
Billions of apoptotic cells are removed daily in a human adult by professional phagocytes (e.g. macrophages) and neighboring nonprofessional phagocytes (e.g. stromal cells). Despite being a type of professional phagocyte, neutrophils are thought to b
Externí odkaz:
https://doaj.org/article/26dc4a5f54e64fc6b2281fc82176b8e2
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
This study highlights the impact of macrophage-derived IGF-1 on the microvascular development in the neonatal intestine and a resulting protective effect against necrotizing enterocolitis.
Externí odkaz:
https://doaj.org/article/2f66fd6df13649eaa48a03e396f415ad
Autor:
Hiroyuki Hirai, Xiubin Liang, Yifei Sun, Yihan Zhang, Jifeng Zhang, Y. Eugene Chen, Hongmei Mou, You-Yang Zhao, Jie Xu
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 11-19 (2022)
Cystic fibrosis (CF) is a lethal autosomal-recessive inherited disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. In the present work, we derived human proximal lung organoids (HLOs) from patient-deriv
Externí odkaz:
https://doaj.org/article/3b0bd80f8db4442d84d9803cd5b8eb3b
Autor:
Slaven Crnkovic, Francesco Valzano, Elisabeth Fließer, Jürgen Gindlhuber, Helene Thekkekara Puthenparampil, Maria Basil, Mike P. Morley, Jeremy Katzen, Elisabeth Gschwandtner, Walter Klepetko, Edward Cantu, Heimo Wolinski, Horst Olschewski, Jörg Lindenmann, You-Yang Zhao, Edward E. Morrisey, Leigh M. Marsh, Grazyna Kwapiszewska
Publikováno v:
JCI Insight, Vol 7, Iss 20 (2022)
A central feature of progressive vascular remodeling is altered smooth muscle cell (SMC) homeostasis; however, the understanding of how different cell populations contribute to this process is limited. Here, we utilized single-cell RNA sequencing to
Externí odkaz:
https://doaj.org/article/44b0a9ebfeff415b9c53d340fe872d68
Autor:
Bin Liu, Dan Yi, Jiakai Pan, Jingbo Dai, Maggie M. Zhu, You‐Yang Zhao, S. Paul Oh, Michael B. Fallon, Zhiyu Dai
Publikováno v:
Pulmonary Circulation, Vol 12, Iss 1, Pp n/a-n/a (2022)
Abstract BMP signaling deficiency is evident in the lungs of patients with pulmonary arterial hypertension. We demonstrated that PHD2 deficiency suppresses BMP signaling in the lung endothelial cells, suggesting the novel mechanisms of dysregulated B
Externí odkaz:
https://doaj.org/article/e3e7950ab3e44c8f94406428c59d1d04
Autor:
Zhiyu Dai, Jianding Cheng, Bin Liu, Dan Yi, Anlin Feng, Ting Wang, Lingling An, Chen Gao, Yibin Wang, Maggie M. Zhu, Xianming Zhang, You‐Yang Zhao
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 22 (2021)
Background Cardiac hypertrophy and fibrosis are common adaptive responses to injury and stress, eventually leading to heart failure. Hypoxia signaling is important to the (patho)physiological process of cardiac remodeling. However, the role of endoth
Externí odkaz:
https://doaj.org/article/02dc5b7e7a6c459c88f08c898ebf63ff
Autor:
Jiannan Gong, Zihang Feng, Abigail L. Peterson, Jennifer F. Carr, Xuexin Lu, Haifeng Zhao, Xiangming Ji, You-Yang Zhao, Monique E. De Paepe, Phyllis A. Dennery, Hongwei Yao
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Dysmorphic pulmonary vascular growth and abnormal endothelial cell (EC) proliferation are paradoxically observed in premature infants with bronchopulmonary dysplasia (BPD), despite vascular pruning. The pentose phosphate pathway (PPP), a metabolic pa
Externí odkaz:
https://doaj.org/article/b9f94dbb034e45fb9de9e1ca4df84791
Publikováno v:
Cells, Vol 11, Iss 9, p 1425 (2022)
There are currently no effective treatments for sepsis and acute respiratory distress syndrome (ARDS). The repositioning of existing drugs is one possible effective strategy for the treatment of sepsis and ARDS. We previously showed that vascular rep
Externí odkaz:
https://doaj.org/article/2faa4f753d5047c9a790ae201313b68d
Autor:
Birendra Chaurasiya, You-Yang Zhao
Publikováno v:
Pharmaceutics, Vol 13, Iss 1, p 31 (2020)
The pulmonary route has long been used for drug administration for both local and systemic treatment. It possesses several advantages, which can be categorized into physiological, i.e., large surface area, thin epithelial membrane, highly vascularize
Externí odkaz:
https://doaj.org/article/baebc840684f410792aacc5cf1fed460
Autor:
Xueke Du, Chunling Jiang, Yang Lv, Randal O Dull, You-Yang Zhao, David E Schwartz, Guochang Hu
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180213 (2017)
A patient's recovery from lung inflammatory injury or development of multi-system organ failure is determined by the host's ability to resolve inflammation and repair tissue damage, both of which require the clearance of apoptotic neutrophils by macr
Externí odkaz:
https://doaj.org/article/61d48b6dfcff4b189436c255a636ad82