Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Yotis A Senis"'
Autor:
Elizabeth J Haining, Kate L Lowe, Surasak Wichaiyo, Raghu P Kataru, Zoltan Nagy, Dean Pj Kavanagh, Sian Lax, Ying Di, Bernhard Nieswandt, Benoît Ho-Tin-Noé, Babak J Mehrara, Yotis A Senis, Julie Rayes, Steve P Watson
Publikováno v:
Platelets, Vol 32, Iss 3, Pp 352-367 (2021)
C-type lectin-like receptor 2 (CLEC-2) is considered as a potential drug target in settings of wound healing, inflammation, and infection. A potential barrier to this is evidence that CLEC-2 and its ligand podoplanin play a critical role in preventin
Externí odkaz:
https://doaj.org/article/a005fc05380f45788ba6052de9029753
Autor:
Juan Carlos Yam-Puc, Lingling Zhang, Raul A Maqueda-Alfaro, Laura Garcia-Ibanez, Yang Zhang, Jessica Davies, Yotis A Senis, Michael Snaith, Kai-Michael Toellner
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102038- (2021)
Summary: It is still not clear how B cell receptor (BCR) signaling intensity affects plasma cell (PC) and germinal center (GC) B cell differentiation. We generated Cγ1Cre/wtPtpn6fl/fl mice where SHP-1, a negative regulator of BCR signaling, is delet
Externí odkaz:
https://doaj.org/article/2683f28e2d1c4ba08fa4c42ead60d9c9
Autor:
Timo Vögtle, Sumana Sharma, Jun Mori, Zoltan Nagy, Daniela Semeniak, Cyril Scandola, Mitchell J Geer, Christopher W Smith, Jordan Lane, Scott Pollack, Riitta Lassila, Annukka Jouppila, Alastair J Barr, Derek J Ogg, Tina D Howard, Helen J McMiken, Juli Warwicker, Catherine Geh, Rachel Rowlinson, W Mark Abbott, Anita Eckly, Harald Schulze, Gavin J Wright, Alexandra Mazharian, Klaus Fütterer, Sundaresan Rajesh, Michael R Douglas, Yotis A Senis
Publikováno v:
eLife, Vol 8 (2019)
The immunoreceptor tyrosine-based inhibition motif (ITIM)-containing receptor G6b-B is critical for platelet production and activation. Loss of G6b-B results in severe macrothrombocytopenia, myelofibrosis and aberrant platelet function in mice and hu
Externí odkaz:
https://doaj.org/article/c344e049fe504f759f1164a922d96039
Autor:
Alexandra Mazharian, Blandine Maître, Alicia Bornert, Desline Hennequin, Marc Lourenco-Rodrigues, Mitchell J. Geer, Christopher W. Smith, Silke Heising, Michaela Walter, Florian Montel, Lucy S. K. Walker, Henri de la Salle, Steve P. Watson, Christian Gachet, Yotis A. Senis
Publikováno v:
Blood Advances. 7:46-59
Mice lacking the immunoreceptor tyrosine-based inhibition motif-containing co-inhibitory receptor G6b-B (Mpig6b, G6b knockout, KO) are born with a complex megakaryocyte (MK) per platelet phenotype, characterized by severe macrothrombocytopenia, expan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620c59da210464487d02a6daff4999b7
https://doi.org/10.1182/bloodadvances.2022008873
https://doi.org/10.1182/bloodadvances.2022008873
Publikováno v:
Journal of Thrombosis and Haemostasis. 21:397-399
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de851e138fd4f1fee1b55c3a43564c07
https://doi.org/10.1016/j.jtha.2022.10.026
https://doi.org/10.1016/j.jtha.2022.10.026
Autor:
Magdolna Nagy, Johanna P. van Geffen, David Stegner, David J. Adams, Attila Braun, Susanne M. de Witt, Margitta Elvers, Mitchell J. Geer, Marijke J. E. Kuijpers, Karl Kunzelmann, Jun Mori, Cécile Oury, Joachim Pircher, Irina Pleines, Alastair W. Poole, Yotis A. Senis, Remco Verdoold, Christian Weber, Bernhard Nieswandt, Johan W. M. Heemskerk, Constance C. F. M. J. Baaten
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 6 (2019)
Genetically modified mice are indispensable for establishing the roles of platelets in arterial thrombosis and hemostasis. Microfluidics assays using anticoagulated whole blood are commonly used as integrative proxy tests for platelet function in mic
Externí odkaz:
https://doaj.org/article/bf144e9b91d74d40b88d09d030089336
Autor:
Cécile Loubière, Emily Janus-Bell, Cyril Scandola, Ahmed Muhammad-Usman, Alexandra A. Yakusheva, Clarisse Mouriaux, Pierre Mangin, Nicolas Receveur, Anita Eckly, Christian Gachet, Mikhail A. Panteleev, Yotis A. Senis, Catherine Bourdon
Publikováno v:
Thrombosis and Haemostasis. 122:767-776
Objective Integrins are key regulators of various platelet functions. The pathophysiological importance of most platelet integrins has been investigated, with the exception of α5β1, a receptor for fibronectin. The aim of this study was to character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9135a5ea67491b59bdda9fd5a7f131b8
https://doi.org/10.1055/a-1659-6214
https://doi.org/10.1055/a-1659-6214
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 5, Iss 3, Pp 376-389 (2021)
Research and Practice in Thrombosis and Haemostasis
Research and Practice in Thrombosis and Haemostasis
Sarcoma (Src) family kinases (SFKs) have occupied a central place in platelet research for over 40 years. Discovered by virologists and oncologists as the proto proto‐oncogene, Src tyrosine kinase spurred a phenomenal burst of research on reversibl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58020d90debe893fb21da50d019581af
https://doaj.org/article/8914ee4b156d4674a45eecafa66736e8
https://doaj.org/article/8914ee4b156d4674a45eecafa66736e8
Autor:
Sian Lax, Babak J. Mehrara, Benoît Ho-Tin-Noé, Kate L. Lowe, Julie Rayes, Bernhard Nieswandt, Dean Pj Kavanagh, Zoltan Nagy, Elizabeth J. Haining, Steve P. Watson, Raghu P. Kataru, Yotis A. Senis, Ying Di, Surasak Wichaiyo
Publikováno v:
Platelets
C-type lectin-like receptor 2 (CLEC-2) is considered as a potential drug target in settings of wound healing, inflammation, and infection. A potential barrier to this is evidence that CLEC-2 and its ligand podoplanin play a critical role in preventin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83035f7eb58b98008f9cf905f2e1b272
http://europepmc.org/articles/PMC8443399
http://europepmc.org/articles/PMC8443399
Catalytic dysregulation of SHP2 leading to Noonan syndromes affects platelet signaling and functions
Autor:
Benjamin G. Neel, Philippe Valet, Alexandra Mazharian, Yotis A. Senis, Jun Mori, Bernard Payrastre, Cendrine Cabou, Thomas Edouard, Sophie Voisin, Cédric Garcia, Marie Bellio, Sonia Severin, Armelle Yart
Publikováno v:
Blood. 134:2304-2317
Src homology 2 domain–containing phosphatase 2 (SHP2), encoded by the PTPN11 gene, is a ubiquitous protein tyrosine phosphatase that is a critical regulator of signal transduction. Germ line mutations in the PTPN11 gene responsible for catalytic ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1cfc4223c2f883ae1350e4908af9a9
https://doi.org/10.1182/blood.2019001543
https://doi.org/10.1182/blood.2019001543