Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Yotaro Matsumoto"'
Autor:
Toma Oshita, Shun Watanabe, Takafumi Toyohara, Ryota Kujirai, Koichi Kikuchi, Takehiro Suzuki, Chitose Suzuki, Yotaro Matsumoto, Jun Wada, Yoshihisa Tomioka, Tetsuhiro Tanaka, Takaaki Abe
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Sensitive biomarkers can enhance the diagnosis, prognosis, and surveillance of chronic kidney disease (CKD), such as diabetic kidney disease (DKD). Plasma growth differentiation factor 15 (GDF15) levels are a novel biomarker for mitochondria
Externí odkaz:
https://doaj.org/article/866bb0472ec8469a9d3954eefae2e1e2
Autor:
Koichi Kikuchi, Daisuke Saigusa, Yoshitomi Kanemitsu, Yotaro Matsumoto, Paxton Thanai, Naoto Suzuki, Koki Mise, Hiroaki Yamaguchi, Tomohiro Nakamura, Kei Asaji, Chikahisa Mukawa, Hiroki Tsukamoto, Toshihiro Sato, Yoshitsugu Oikawa, Tomoyuki Iwasaki, Yuji Oe, Tomoya Tsukimi, Noriko N. Fukuda, Hsin-Jung HO, Fumika Nanto-Hara, Jiro Ogura, Ritsumi Saito, Shizuko Nagao, Yusuke Ohsaki, Satoshi Shimada, Takehiro Suzuki, Takafumi Toyohara, Eikan Mishima, Hisato Shima, Yasutoshi Akiyama, Yukako Akiyama, Mariko Ichijo, Tetsuro Matsuhashi, Akihiro Matsuo, Yoshiaki Ogata, Ching-Chin Yang, Chitose Suzuki, Matthew C. Breeggemann, Jurgen Heymann, Miho Shimizu, Susumu Ogawa, Nobuyuki Takahashi, Takashi Suzuki, Yuji Owada, Shigeo Kure, Nariyasu Mano, Tomoyoshi Soga, Takashi Wada, Jeffrey B. Kopp, Shinji Fukuda, Atsushi Hozawa, Masayuki Yamamoto, Sadayoshi Ito, Jun Wada, Yoshihisa Tomioka, Takaaki Abe
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Diabetes is a major cause of kidney disease. Here Kikuchi et al. show that phenol sulfate, a gut microbiota-derived metabolite, is increased in diabetic kidney disease and contributes to the pathology by promoting kidney injury, suggesting phenyl sul
Externí odkaz:
https://doaj.org/article/4b7ee8aaa8cd44e3ba881e3d9e920e28
Autor:
Emiko Sato, Daisuke Saigusa, Eikan Mishima, Taeko Uchida, Daisuke Miura, Tomomi Morikawa-Ichinose, Kiyomi Kisu, Akiyo Sekimoto, Ritsumi Saito, Yuji Oe, Yotaro Matsumoto, Yoshihisa Tomioka, Takefumi Mori, Nobuyuki Takahashi, Hiroshi Sato, Takaaki Abe, Toshimitsu Niwa, Sadayoshi Ito
Publikováno v:
Toxins, Vol 10, Iss 1, p 19 (2017)
Elevated circulating uremic toxins are associated with a variety of symptoms and organ dysfunction observed in patients with chronic kidney disease (CKD). Indoxyl sulfate (IS) and p-cresyl sulfate (PCS) are representative uremic toxins that exert var
Externí odkaz:
https://doaj.org/article/d25f222df81b440280857dbceb85f58e
Autor:
Taku Nakai, Yuma Iwamura, Koichiro Kato, Ikuo Hirano, Yotaro Matsumoto, Yoshihisa Tomioka, Masayuki Yamamoto, Norio Suzuki
Publikováno v:
Blood Advances.
The erythroid growth factor erythropoietin (EPO) is mainly produced by the kidneys in adult mammals and induces expansion of erythroid cells and iron use for hemoglobin synthesis. The liver also produces EPO at a lower level than the kidneys. Renal a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90feaf619319c9fac3bc62d8e9bee03d
https://doi.org/10.1182/bloodadvances.2023009798
https://doi.org/10.1182/bloodadvances.2023009798
Autor:
Michiaki Hiramatsu, Yuichi Hashimoto, Masanobu Uchiyama, Makoto Makishima, Atsuya Muranaka, Yusuke Mita, Yui Masumoto, Yuki Ichikawa, Yotaro Matsumoto, Minoru Ishikawa
Publikováno v:
Organic & Biomolecular Chemistry. 19:446-456
Aqueous solubility is a key requirement for small-molecule drug candidates. Here, we investigated the regioisomer–physicochemical property relationships of disubstituted benzenes. We found that meta-isomers bearing non-flat substituents tend to pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab6a309835a4ce0800b375a7e5b246c1
https://doi.org/10.1039/d0ob02083d
https://doi.org/10.1039/d0ob02083d
Autor:
Ritsumi Saito, Teiji Tominaga, Masayuki Yamamoto, Daisuke Saigusa, Takahiro Yamazaki, Yoshihisa Tomioka, Akira Uruno, Yotaro Matsumoto, Sherif Rashad, Kuniyasu Niizuma
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Understanding the root causes of neuronal vulnerability to ischemia is paramount to the development of new therapies for stroke. Transient global cerebral ischemia (tGCI) leads to selective neuronal cell death in the CA1 sub-region of the hippocampus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed147a8a9ef0918ee1c64b77ecd04d2
http://link.springer.com/article/10.1038/s41598-020-63483-w
http://link.springer.com/article/10.1038/s41598-020-63483-w
Autor:
Taku Nakai, Daisuke Saigusa, Yuma Iwamura, Yotaro Matsumoto, Keiko Umeda, Koichiro Kato, Hayato Yamaki, Yoshihisa Tomioka, Ikuo Hirano, Seizo Koshiba, Masayuki Yamamoto, Norio Suzuki
Publikováno v:
Biochemical pharmacology. 197
Kidney injury often causes anemia due to a lack of production of the erythroid growth factor erythropoietin (EPO) in the kidneys. Roxadustat is one of the first oral medicines inducing EPO production in patients with renal anemia by activating hypoxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc66bde8c196c2ab8be9bc9b40316fc5
https://pubmed.ncbi.nlm.nih.gov/35114188
https://pubmed.ncbi.nlm.nih.gov/35114188
Autor:
Yoshiteru Oshima, Junken Aoki, Elias Al-Mamun, Mohammad Abdul Hai Siddique, Masamichi Nogi, Masayuki Yamamoto, Takayuki Doi, Nobuhiro Kikuchi, Daisuke Saigusa, Kimio Satoh, Yotaro Matsumoto, Shinichiro Sunamura, Satoshi Miyata, Kuniyuki Kano, Kazuhiko Numano, Ryo Kurosawa, Haruhisa Kikuchi, Akira Uruno, Junichi Omura, Hiroaki Shimokawa, Taijyu Satoh
Publikováno v:
Circulation Research. 125:309-327
Rationale: Pulmonary arterial hypertension (PAH) is characterized by enhanced proliferation of pulmonary artery smooth muscle cells (PASMCs) accompanying increased production of inflammatory factors and adaptation of the mitochondrial metabolism to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6608b9727e4287da8c947bf4d916dd4d
https://doi.org/10.1161/circresaha.119.315229
https://doi.org/10.1161/circresaha.119.315229
Autor:
Akira Suda, Yoku Kikuchi, Tomohiko Shindo, Hiroaki Shimokawa, Jun Takahashi, Kensuke Nishimiya, Shigeo Godo, Kiyotaka Hao, Jun Sugisawa, Yotaro Matsumoto, Takashi Shiroto, Koichi Satoh
Publikováno v:
European Heart Journal. 41
Introduction Ischemia and non-obstructive coronary artery disease (INOCA), including microvascular spasm (MVS) and epicardial spasm, has recently attracted much attention, for which in vivo imaging evaluation for coronary artery morphology is warrant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::302136980c9b7dae64f230f46a79849e
https://doi.org/10.1093/ehjci/ehaa946.1522
https://doi.org/10.1093/ehjci/ehaa946.1522
Autor:
Tomoyoshi Soga, Sadayoshi Ito, Eikan Mishima, Chitose Suzuki, Noriko N. Fukuda, Yotaro Matsumoto, Daisuke Saigusa, Takehiro Suzuki, Tatsuki Tachikawa, Chikahisa Mukawa, Yoshitomi Kanemitsu, Hiroki Tsukamoto, Yoshihisa Tomioka, Koichi Kikuchi, Kei Asaji, Fumika Nanto, Hsin Jung Ho, Shinji Fukuda, Takaaki Abe, Tomoya Tsukimi
Publikováno v:
American Journal of Physiology-Renal Physiology. 315:F824-F833
Accumulation of uremic toxins, which exert deleterious effects in chronic kidney disease, is influenced by the intestinal environment; the microbiota contributes to the production of representative uremic toxins, including p-cresyl sulfate and indoxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586ce5cdb17de8cd4555fe6301ff790e
https://doi.org/10.1152/ajprenal.00314.2017
https://doi.org/10.1152/ajprenal.00314.2017