Intradermal injection of lidocaine with a microneedle device to provide rapid local anaesthesia for peripheral intravenous cannulation: A randomised open-label placebo-controlled clinical trial

Autor: Alexey Rzhevskiy, Andrei Popov, Chavdar Pavlov, Yuri Anissimov, Andrei Zvyagin, Yotam Levin, Efrat Kochba

Publikováno v: PLoS ONE, Vol 17, Iss 1 (2022)

Background Peripheral venous cannulation is one of the most common procedures in medicine. It is associated with noticeable pain and apprehension, although in most cases it is performed without any anesthesia due to lack of a painless, cost-effective

Externí odkaz: https://doaj.org/article/738ddc2337d4422db81aaee49e823753

Intradermal Delivery of Synthetic mRNA Using Hollow Microneedles for Efficient and Rapid Production of Exogenous Proteins in Skin

Autor: Sonia Golombek, Martin Pilz, Heidrun Steinle, Efrat Kochba, Yotam Levin, Dominique Lunter, Christian Schlensak, Hans Peter Wendel, Meltem Avci-Adali

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 11, Iss C, Pp 382-392 (2018)

In recent years, synthetic mRNA-based applications to produce desired exogenous proteins in cells have been gaining importance. However, systemic delivery of synthetic mRNA can result in unspecific uptake into undesired cells or organs and, thereby,

Externí odkaz: https://doaj.org/article/2263849dcf0a44e2b2d6e900dc86d8a5

A Double-blind, Randomized Phase 2 Controlled Trial of Intradermal Hepatitis B Vaccination With a Topical Toll-like Receptor 7 Agonist Imiquimod, in Patients on Dialysis

Autor: SL Lui, Efrat Kochba, Kwok-Hung Chan, Man-Fung Yuen, Johnson Y.N. Lau, Desmond Y H Yap, Ricky Ruiqi Zhang, Yotam Levin, Kwok-Yung Yuen, Tak Mao Chan, Ivan Hung, Kelvin K. W. To, Terence P.S. Yip, Sydney C.W. Tang

Publikováno v: Clinical Infectious Diseases. 73:e304-e311

Background Patients on dialysis are hyporesponsive to the hepatitis B virus vaccines (HBVv). We examined intradermal (ID) HBVv Sci-B-Vac, with topical Toll-like receptor 7 (TLR7) agonist imiquimod pretreatment in dialysis patients. Methods We enrolle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44513d85a14c3aef5908da2bae0153f
https://doi.org/10.1093/cid/ciaa804

Ethics and execution of developing a 2nd wave COVID vaccine – Our interim phase I/II VSV-SARS-CoV2 vaccine experience

Autor: Yoseph Caraco, Jacob Atsmon, Noa Madar Balakirski, Eytan Ben-Ami, Yotam Levin, Hadar Marcus

Publikováno v: Vaccine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2acb4e3c606ec8e18d3d82589693e8
https://doi.org/10.1016/j.vaccine.2021.04.017

Using gold nanoparticles for enhanced intradermal delivery of poorly soluble auto-antigenic peptides

Autor: Bernard Malissen, Martina A. McAteer, James Caradoc Birchall, Colin M. Dayan, Yotam Levin, F. Susan Wong, Sandrine Henri, Joanne Davies, Efrat Kochba, Ravinder K. Singh, Jan Mous, Camille Malosse, Sion Coulman

Publikováno v: Nanomedicine: Nanotechnology, Biology and Medicine
Nanomedicine: Nanotechnology, Biology and Medicine, 2020, ⟨10.1016/j.nano.2020.102321⟩
Nanomedicine: Nanotechnology, Biology and Medicine, Elsevier, 2020, ⟨10.1016/j.nano.2020.102321⟩

International audience; Ultra-small 1-2 nm gold nanoparticles (NP) were conjugated with a poorly-soluble peptide auto-antigen, associated with type 1 diabetes, to modify the peptide pharmacokinetics, following its intradermal delivery. Peptide distri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33db1447d49f7807136dd9ea409af277
https://orca.cardiff.ac.uk/id/eprint/136850/1/Using+gold+nanoparticles+for+enhanced+intradermal+delivery+of+poorly+soluble+auto-antigenic+peptides+.pdf