Výsledky vyhledávání - "Yosuke Ogoshi"

Discovery of Selective Transforming Growth Factor β Type II Receptor Inhibitors as Antifibrosis Agents

Autor: Yoshifumi Ueyama, Yutaka Ukaji, Keisuke Nozawa, Katsuya Maeda, Shohei Miwa, Tomohiro Ishikawa, Yuki Kitao, Tsuyoshi Adachi, Naoki Ogawa, Makoto Shiozaki, Yokota Masahiro, Yosuke Ogoshi, Seki Noriyoshi, Jun Nishihata, Akihiro Nomura

Publikováno v: ACS Med Chem Lett

[Image: see text] Historically, modulation of transforming growth factor β (TGF-β) signaling has been deemed a rational strategy to treat many disorders, though few successful examples have been reported to date. This difficulty could be partially

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5975305876bfb25ddade8d015eb99ad2
https://pubmed.ncbi.nlm.nih.gov/34055221

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Discovery of potent liver-selective stearoyl-CoA desaturase-1 (SCD1) inhibitors, thiazole-4-acetic acid derivatives, for the treatment of diabetes, hepatic steatosis, and obesity

Autor: Masahiro Tanaka, Tetsuya Iida, Mitani Ikuo, Shohei Sakata, Yosuke Ogoshi, Hiroto Imai, Nakagawa Yuichi, Minoru Ubukata, Takashi Inaba, Katsuya Maeda, Hisayo Morinaga, Tamotsu Negoro, Shin-ichi Oshida, Ryuhei Sano, Hotta Takahiro

Publikováno v: European Journal of Medicinal Chemistry. 158:832-852

SCD1 is a rate-limiting enzyme in the conversion of saturated fatty acids to monounsaturated fatty acids. SCD1 inhibitors have potential effects on obesity, diabetes, acne, and cancer, but the adverse effects associated with SCD1 inhibition in the sk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942eb800910bb4018c26dc0b2b32ac78
https://doi.org/10.1016/j.ejmech.2018.09.003

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Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the Treatment of Renal Anemia

Autor: Mitani Ikuo, Motoda Dai, Masakazu Terashita, Kenji Fukui, Yasunori Hase, Yokota Masahiro, Hotta Takahiro, Soichiro Ito, Hiroyuki Abe, Yosuke Ogoshi, Katsuya Deai, Hiromi Yoshiuchi, Ito Takashi, Kazuhito Ueyama, Takuya Matsui

Publikováno v: ACS Medicinal Chemistry Letters. 8:1320-1325

Inhibition of hypoxia inducible factor prolyl hydroxylase (PHD) represents a promising strategy for the discovery of a next generation treatment for renal anemia. We identified several 5,6-fused ring systems as novel scaffolds of the PHD inhibitor on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4368beded07f0bdc3c33801b91b038
https://doi.org/10.1021/acsmedchemlett.7b00404

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Synthesis and SAR of 2-phenyl-1-sulfonylaminocyclopropane carboxylates as ADAMTS-5 (Aggrecanase-2) inhibitors

Autor: Akira Suma, John A. Josey, Andrew M. Fryer, Katsuya Maeda, Hiromi Yoshiuchi, Yokota Masahiro, Hiroto Imai, Yosuke Ogoshi, Ellen R. Laird, Takayuki Mimura, Nicole M. Littmann, Takashi Inaba, Katsutaka Yasue, Andrews Steven W, Julia Haas, Tomoya Miura, Makoto Shiozaki, Yuichi Shinozaki

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:6213-6217

A series of 1-sulfonylaminocyclopropanecarboxylates was synthesized as ADAMTS-5 (Aggrecanase-2) inhibitors. After an intensive investigation of the central cyclopropane core including its absolute stereochemistry and substituents, we found compound 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a96edd54e00a401d11e37b11d5525e4
https://doi.org/10.1016/j.bmcl.2009.08.093

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Asymmetric synthesis of isobenzofuranone derivatives and their unique character as protein kinase Cα (PKCα) activators

Autor: Yosuke Ogoshi, Go Hirai, Mikiko Sodeoka, Tadashi Shimizu, Yuki Tamura, Toru Watanabe, Megumi Ohkubo

Publikováno v: Tetrahedron Letters. 50:3609-3612

Efficient enantio-selective synthesis of conformationally constrained diacylglycerol analogues, 7-substituted isobenzofuranone derivatives, originally developed by us as PKCα ligands, was achieved by asymmetric dihydroxylation and γ-lactone formati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05788909d9dd43463d0751852fd057a7
https://doi.org/10.1016/j.tetlet.2009.03.069

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Analysis of Light Propagation in a Realistic Head Model by a Hybrid Method for Optical Brain Function Measurement

Autor: Eiji Okada, Yosuke Ogoshi

Publikováno v: Optical Review. 12:264-269

Near infrared spectroscopy (NIRS) is used to measure the change in blood volume and oxygenation in the brain cortex induced by functional brain activation. The development of an adequate model to calculate light propagation in the head is very import

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::20c76d7d29dd28298f1054edc0b0937c
https://doi.org/10.1007/s10043-005-0264-y

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Evaluation of series of isobenzofuranone dimers as PKCα ligands: implication for the distance between the two ligand binding sites

Autor: Yuichi Hashimoto, Yoshiyasu Baba, Takeshi Yanagisawa, Satoshi Mayumi, Go Hirai, Hidekazu Kawasaki, Mikiko Sodeoka, Yosuke Ogoshi

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 14:2969-2972

Protein kinase C (PKC) is a family of enzymes, which play important roles in intracellular signal transduction. To examine the distance between the two ligand binding sites (C1A and C1B) of PKC, we designed and synthesized two series of isobenzofuran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27013a3e716c2b2d19683e4412ef1be
https://doi.org/10.1016/j.bmcl.2004.02.098

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Novel N-substituted 2-phenyl-1-sulfonylamino-cyclopropane carboxylates as selective ADAMTS-5 (Aggrecanase-2) inhibitors

Autor: Nicole M. Littmann, Takashi Inaba, Katsuya Maeda, Yosuke Ogoshi, Andrews Steven W, Julia Haas, John A. Josey, Takayuki Mimura, Andrew M. Fryer, Makoto Shiozaki, Yuichi Shinozaki, Tomoya Miura, Ellen R. Laird, Hiromi Yoshiuchi

Publikováno v: Bioorganicmedicinal chemistry letters. 19(6)

A series of N-substituted sulfonylamino-alkanecarboxylate ADAMTS-5 (Aggrecanase-2) inhibitors has been synthesized and the in vitro enzyme SAR is discussed. This report is the first example of carboxylate-based ADAMTS-5 inhibitors which show strong p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b1da071c64c05bfc7da65c200749070
https://pubmed.ncbi.nlm.nih.gov/19243944

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Analysis of light propagation in adult head model by direct hybrid monte carlo-diffusion method

Autor: Yosuke Ogoshi, T. Hayashi, Yuichi Fukui, Eiji Okada

Publikováno v: IEEE EMBS Asian-Pacific Conference on Biomedical Engineering, 2003..

The development of a model to calculate light propagation in the head is essential for brain function measurement by near-infrared spectroscopy and imaging. The light propagation in the head is affected by low-scattering cerebrospinal fluid layer sur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e3430cc4a0d66ba13b89e7e8cf8d493
https://doi.org/10.1109/apbme.2003.1302711

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