Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Yosuke Hiramuki"'
Autor:
Masahito Watanabe, Hitomaru Miyamoto, Kazutoshi Okamoto, Kazuaki Nakano, Hitomi Matsunari, Kanako Kazuki, Koki Hasegawa, Ayuko Uchikura, Shuko Takayanagi, Kazuhiro Umeyama, Yosuke Hiramuki, Elisabeth Kemter, Nikolai Klymuik, Mayuko Kurome, Barbara Kessler, Eckhard Wolf, Yasuhiro Kazuki, Hiroshi Nagashima
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 444-453 (2023)
Mammalian artificial chromosomes have enabled the introduction of extremely large amounts of genetic information into animal cells in an autonomously replicating, nonintegrating format. However, the evaluation of human artificial chromosomes (HACs) a
Externí odkaz:
https://doaj.org/article/7a8c635119da410397f678e585a6364e
Autor:
Yosuke Hiramuki, Satoshi Abe, Narumi Uno, Kanako Kazuki, Shuta Takata, Hitomaru Miyamoto, Haruka Takayama, Kayoko Morimoto, Shoko Takehara, Mitsuhiko Osaki, Jun Tanihata, Shin’ichi Takeda, Kazuma Tomizuka, Mitsuo Oshimura, Yasuhiro Kazuki
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Dystrophin maintains membrane integrity as a sarcolemmal protein. Dystrophin mutations lead to Duchenne muscular dystrophy, an X-linked recessive disorder. Since dystrophin is one of the largest genes consisting of 79 exons in the human geno
Externí odkaz:
https://doaj.org/article/232b2a6750bd4df6b4d27f2d86136a45
Autor:
Yosuke Hiramuki, Yuriko Kure, Yoshihiko Saito, Megumu Ogawa, Keiko Ishikawa, Madoka Mori-Yoshimura, Yasushi Oya, Yuji Takahashi, Dae-Seong Kim, Noriko Arai, Chiaki Mori, Tsuyoshi Matsumura, Tadanori Hamano, Kenichiro Nakamura, Koji Ikezoe, Shinichiro Hayashi, Yuichi Goto, Satoru Noguchi, Ichizo Nishino
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-12 (2022)
Abstract Background Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant muscular disorder characterized by asymmetric muscle wasting and weakness. FSHD can be subdivided into two types: FSHD1, caused by contraction of the D4Z4 repe
Externí odkaz:
https://doaj.org/article/232b7b90ca3f41728eb543822e9d6aba
Autor:
Yosuke Hiramuki, Stephen J. Tapscott
Publikováno v:
Skeletal Muscle, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract Background SMCHD1 is a disease modifier and a causative gene for facioscapulohumeral muscular dystrophy (FSHD) type 1 and type 2, respectively. A large variety of different mutations in SMCHD1 have been identified as causing FSHD2. In many c
Externí odkaz:
https://doaj.org/article/dd1ac626ecdb44f2acc5d9510effdde5
Autor:
Amy E. Campbell, Jonathan Oliva, Matthew P. Yates, Jun Wen Zhong, Sean C. Shadle, Lauren Snider, Nikita Singh, Shannon Tai, Yosuke Hiramuki, Rabi Tawil, Silvère M. van der Maarel, Stephen J. Tapscott, Francis M. Sverdrup
Publikováno v:
Skeletal Muscle, Vol 7, Iss 1, Pp 1-18 (2017)
Abstract Background Facioscapulohumeral dystrophy (FSHD) is a progressive muscle disease caused by mutations that lead to epigenetic derepression and inappropriate transcription of the double homeobox 4 (DUX4) gene in skeletal muscle. Drugs that enha
Externí odkaz:
https://doaj.org/article/851f6001f8d54b48828ccacb12eb6194
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130436 (2015)
When skeletal muscle fibers are injured, they regenerate and grow until their sizes are adjusted to surrounding muscle fibers and other relevant organs. In this study, we examined whether Mest, one of paternally expressed imprinted genes that regulat
Externí odkaz:
https://doaj.org/article/ecb86546c2a94188a4bcda48f0ebc6d3
Autor:
Yosuke Hiramuki, Yuriko Kure, Yoshihiko Saito, Megumu Ogawa, Keiko Ishikawa, Madoka Mori-Yoshimura, Yasushi Oya, Yuji Takahashi, Dae-Seong Kim, Noriko Arai, Chiaki Mori, Tsuyoshi Matsumura, Tadanori Hamano, Kenichiro Nakamura, Koji Ikezoe, Shinichiro Hayashi, Yuichi Goto, Satoru Noguchi, Ichizo Nishino
SummaryFacioscapulohumeral muscular dystrophy (FSHD) can be subdivided into two types: FSHD1, caused by contraction of the D4Z4 repeat on chromosome 4q35, and FSHD2, caused by mild contraction of the D4Z4 repeat plus aberrant hypomethylation mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a70612bbecdbb134a4b2b70d33602c09
https://doi.org/10.1101/2022.06.24.22276750
https://doi.org/10.1101/2022.06.24.22276750
Publikováno v:
The FASEB Journal. 33:8094-8109
Skeletal muscle satellite cells (SMSCs), the major stem cells responsible for the regeneration of skeletal muscle, are normally cell cycle arrested but differentiate to generate myocytes upon muscle damage, forming new myofibers along with self-renew
Autor:
Shigeru Taketani, Atsuko Fujisawa-Sehara, Takahiko Sato, Hanako Naitoh, Yukari Suganuma, Masasuke Araki, Yoko Ueda, Yosuke Hiramuki
Publikováno v:
Developmental Neurobiology. 77:1086-1100
In adult Xenopus eyes, when the whole retina is removed, retinal pigmented epithelial (RPE) cells become activated to be retinal stem cells and regenerate the whole retina. In the present study, using a tissue culture model, it was examined whether u
Autor:
Miha Pakusch, Jessica C. de Greef, Silvère M. van der Maarel, Daniela C.F. Salvatori, Bram Slütter, Kelsey Breslin, Lauren Snider, Yvonne D. Krom, Rabi Tawil, Bianca den Hamer, Rob F. P. van den Akker, Marnie E. Blewitt, Stephen J. Tapscott, Yosuke Hiramuki
Publikováno v:
Human Molecular Genetics, 27(4), 716-731
Human Molecular Genetics
Human Molecular Genetics
In humans, a copy of the DUX4 retrogene is located in each unit of the D4Z4 macrosatellite repeat that normally comprises 8-100 units. The D4Z4 repeat has heterochromatic features and does not express DUX4 in somatic cells. Individuals with facioscap