Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Yosuke, Funato"'
Autor:
Yosuke Funato, Mai Mimura, Kazuto Nunomura, Bangzhong Lin, Shintarou Fujii, Junichi Haruta, Hiroaki Miki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Phosphatase of regenerating liver (PRL) is an oncogenic protein that promotes tumor progression by directly binding to cyclin M (CNNM) membrane proteins and inhibiting their Mg2+ efflux activity. In this study, we have developed a high-throu
Externí odkaz:
https://doaj.org/article/3586ef48f07b4cb194e89b64ca504b67
PRL stimulates mitotic errors by suppressing kinetochore-localized activation of AMPK during mitosis
Publikováno v:
Cell Structure and Function, Vol 47, Iss 2, Pp 75-87 (2022)
Phosphatase of regenerating liver (PRL) is frequently overexpressed in various malignant cancers and is known to be a driver of malignancy. Here, we demonstrated that PRL overexpression causes mitotic errors that accompany spindle misorientation and
Externí odkaz:
https://doaj.org/article/d616a418b3994ef1b2421e2b1d58c39a
Autor:
Yosuke Funato, Hiroaki Miki
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 1, Pp 14-18 (2022)
Cyclin M (CNNM) and its prokaryotic ortholog CorC belong to a family of proteins that function as Mg2+-extruding transporters by stimulating Na+/Mg2+ exchange, and thereby control intracellular Mg2+ levels. The Mg2+-extruding function of CNNM is inhi
Externí odkaz:
https://doaj.org/article/82767a2f421b483ca5c5b42a61d474c2
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Circadian variation of blood pressure, with higher values in the active period, is associated with the risk of fatal cardiovascular events. Here, we show the importance of renal TRPM6, a Magnesium-permeable cation channel, in raising blood pressure b
Externí odkaz:
https://doaj.org/article/19ab4e3777194204aa8e0dcab04a04d6
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Adenomatous polyposis coli (APC) is a tumor-suppressing protein whose inactivation triggers the formation of colorectal polyps. Numerous studies using cell lines or genetically engineered mice have revealed its role in suppressing Wnt/β-cat
Externí odkaz:
https://doaj.org/article/2b1a581672fc4c0aa6e1d5883a21459d
Autor:
Yichen Huang, Kaijie Mu, Xinyu Teng, Yimeng Zhao, Yosuke Funato, Hiroaki Miki, Weiliang Zhu, Zhijian Xu, Motoyuki Hattori
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102370- (2021)
Summary: The CorC/CNNM family of Na+-dependent Mg2+ transporters is ubiquitously conserved from bacteria to humans. CorC, the bacterial CorC/CNNM family of proteins, is involved in resistance to antibiotic exposure and in the survival of pathogenic m
Externí odkaz:
https://doaj.org/article/7156af8ee327407d98439d603288e9dd
Autor:
Yanying Wu, Yosuke Funato, Eleonora Meschi, Kristijan D Jovanoski, Hiroaki Miki, Scott Waddell
Publikováno v:
eLife, Vol 9 (2020)
Dietary magnesium (Mg2+) supplementation can enhance memory in young and aged rats. Memory-enhancing capacity was largely ascribed to increases in hippocampal synaptic density and elevated expression of the NR2B subunit of the NMDA-type glutamate rec
Externí odkaz:
https://doaj.org/article/5738768bc0fb419bb4416754ecc5d583
Publikováno v:
Cancer Science. 114:25-33
Phosphatase of regenerating liver (PRL) is a family of protein tyrosine phosphatases (PTPs) that are anchored to the plasma membrane by prenylation. They are frequently overexpressed in various types of malignant cancers and their roles in cancer pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eff909596cba8cbd0cdb0db9d55014ce
https://doi.org/10.1111/cas.15625
https://doi.org/10.1111/cas.15625
Autor:
Hiroaki Miki, Yosuke Funato
Publikováno v:
Journal of Pharmacological Sciences, Vol 148, Iss 1, Pp 14-18 (2022)
Cyclin M (CNNM) and its prokaryotic ortholog CorC belong to a family of proteins that function as Mg2+-extruding transporters by stimulating Na+/Mg2+ exchange, and thereby control intracellular Mg2+ levels. The Mg2+-extruding function of CNNM is inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1d0724c83e108de04335847726de94
https://doi.org/10.1016/j.jphs.2021.09.004
https://doi.org/10.1016/j.jphs.2021.09.004
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Blood pressure has a daily pattern, with higher values in the active period. Its elevation at the onset of the active period substantially increases the risk of fatal cardiovascular events. Renin secretion stimulated by renal sympathetic neurons is c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0eb862fe37003dec4b7a4753f2d4688
https://doaj.org/article/19ab4e3777194204aa8e0dcab04a04d6
https://doaj.org/article/19ab4e3777194204aa8e0dcab04a04d6