Discovery of -Arrestin-Biased Dopamine D2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy

Autor: Setola, V., Jensen, N. H., Jin, J., Feng, B., Wetsel, W. C., Frye, S. V., Caron, M. G., Chen, M., Roth, B. L., Allen, J. A., Yadav, P. N., Bai, X., Sassano, M. F., Yost, J. M., Chen, X., Peterson, S., Javitch, J. A., Che, X., Huang, X.-p.

Elucidating the key signal transduction pathways essential for both antipsychotic efficacy and side-effect profiles is essential for developing safer and more effective therapies. Recent work has highlighted noncanonical modes of dopamine D2 receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b00eae60d70e28b477b2c1c18804ba9c

Strategies for Promoting Catalytic Performance of Ru‐Based Electrocatalysts towards Oxygen/Hydrogen Evolution Reaction.

Autor: Chu, Xianxu¹ (AUTHOR), Wang, Lu¹ (AUTHOR), Li, Junru^1,2 (AUTHOR), Xu, Hui² (AUTHOR) xuhui006@cczu.edu.cn

Publikováno v: Chemical Record. Apr2023, Vol. 23 Issue 4, p1-21. 21p.

Herbarium records reveal multiple phases in the relationship between minimum residence time and invasion ranges of alien plant species.

Autor: Ni, Ming¹ (AUTHOR) ming.ni@usherbrooke.ca

Publikováno v: Plants, People, Planet. Jan2023, Vol. 5 Issue 1, p47-57. 11p.

Phosphorylation Signals Downstream of Dopamine Receptors in Emotional Behaviors: Association with Preference and Avoidance.

Autor: Zhang, Xinjian¹ (AUTHOR), Tsuboi, Daisuke^2,3 (AUTHOR), Funahashi, Yasuhiro^2,3 (AUTHOR), Yamahashi, Yukie^2,3 (AUTHOR), Kaibuchi, Kozo^2,3 (AUTHOR) kaibuchi@fujita-hu.ac.jp, Nagai, Taku¹ (AUTHOR) kaibuchi@fujita-hu.ac.jp

Publikováno v: International Journal of Molecular Sciences. Oct2022, Vol. 23 Issue 19, p11643. 15p.

Progress on the development of Class A GPCR-biased ligands.

Autor: Morales P; Instituto de Química Médica, Consejo Superior de Investigaciones Científicas, Madrid, Spain., Scharf MM; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Bermudez M; Institute for Pharmaceutical and Medicinal Chemistry, University of Münster, Münster, Germany., Egyed A; Medicinal Chemistry Research Group and National Drug Discovery and Development Laboratory, Research Centre for Natural Sciences, Budapest, Hungary., Franco R; Molecular Neurobiology Laboratory, Department of Biochemistry and Molecular Biology, Universitat de Barcelona, Barcelona, Spain.; CiberNed. Network Center for Neurodegenerative Diseases, National Spanish Health Institute Carlos III, Madrid, Spain.; School of Chemistry, Universitat de Barcelona, Barcelona, Spain., Hansen OK; Laboratory of Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jagerovic N; Instituto de Química Médica, Consejo Superior de Investigaciones Científicas, Madrid, Spain., Jakubík J; Institute of Physiology Czech Academy of Sciences, Prague, Czech Republic., Keserű GM; Medicinal Chemistry Research Group and National Drug Discovery and Development Laboratory, Research Centre for Natural Sciences, Budapest, Hungary., Kiss DJ; Medicinal Chemistry Research Group and National Drug Discovery and Development Laboratory, Research Centre for Natural Sciences, Budapest, Hungary., Kozielewicz P; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden., Larsen O; Laboratory of Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Majellaro M; Celtarys Research S.L., Santiago de Compostela, Spain., Mallo-Abreu A; Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, Santiago de Compostela, Spain.; Laboratory of Medicinal Chemistry (CSIC Associated Unit), Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, Barcelona, Spain.; Institute of Biomedicine (IBUB), Universitat de Barcelona, Barcelona, Spain., Navarro G; CiberNed. Network Center for Neurodegenerative Diseases, National Spanish Health Institute Carlos III, Madrid, Spain.; Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Science, Universitat de Barcelona, Barcelona, Spain., Prieto-Díaz R; Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, Santiago de Compostela, Spain., Rosenkilde MM; Laboratory of Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sotelo E; Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, Santiago de Compostela, Spain., Stark H; Heinrich Heine University Düsseldorf, Institut fuer Pharmazeutische und Medizinische Chemie, Duesseldorf, Germany., Werner T; Heinrich Heine University Düsseldorf, Institut fuer Pharmazeutische und Medizinische Chemie, Duesseldorf, Germany., Wingler LM; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2024 Sep 11. Date of Electronic Publication: 2024 Sep 11.