Výsledky vyhledávání - "Yossi Saragani"

Removal of ribonucleotides by p53 protein incorporated during DNA synthesis by HIV-1 reverse transcriptase

Autor: Yossi Saragani, Amnon Hizi, Tzofit Akua, Galia Rahav, Mary Bakhanashvili

Publikováno v: AIDS. 31:343-353

OBJECTIVE(S) HIV-1 reverse transcriptase frequently incorporates ribonucleotides into the proviral DNA in macrophages, but not in lymphocytes. The enzyme exerts an efficient ribonucleotide-terminated primer extension capacity. Furthermore, ribonucleo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36b5501af02b9f48a9b635adc9537d4
https://doi.org/10.1097/qad.0000000000001339

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Cytoplasmic p53 contributes to the removal of uracils misincorporated by HIV-1 reverse transcriptase

Autor: Mary Bakhanashvili, Sara Zaouch, Amnon Hizi, Galia Rahav, Yossi Saragani

Publikováno v: Biochemical and biophysical research communications. 497(2)

HIV-1 reverse transcriptase (RT) in the cytoplasm of HIV-infected cells efficiently inserts the non-canonical dUTP into the proviral DNA, and extends the dU-terminated DNA. The misincorporation of dUTP leads to mutagenesis, and uracils can down-regul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076f80278e8e08287d8f27780b85fd56
https://pubmed.ncbi.nlm.nih.gov/29470985

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