Výsledky vyhledávání - "Yosser Zina, Abdelkrim"

Akademický článek

Approved drugs successfully repurposed against Leishmania based on machine learning predictions

Autor: Rafeh Oualha, Yosser Zina Abdelkrim, Ikram Guizani, Emna Harigua-Souiai

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)

Drug repurposing is a promising approach towards the discovery of novel treatments against Neglected Tropical Diseases, such as Leishmaniases, presenting the advantage of reducing both costs and duration of the drug discovery process. In previous wor

Externí odkaz: https://doaj.org/article/306d9dbeb6ee4b7ca8fd1aa212a7f481

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Akademický článek

Deep Learning Algorithms Achieved Satisfactory Predictions When Trained on a Novel Collection of Anticoronavirus Molecules

Autor: Emna Harigua-Souiai, Mohamed Mahmoud Heinhane, Yosser Zina Abdelkrim, Oussama Souiai, Ines Abdeljaoued-Tej, Ikram Guizani

Publikováno v: Frontiers in Genetics, Vol 12 (2021)

Drug discovery and repurposing against COVID-19 is a highly relevant topic with huge efforts dedicated to delivering novel therapeutics targeting SARS-CoV-2. In this context, computer-aided drug discovery is of interest in orienting the early high th

Externí odkaz: https://doaj.org/article/7bc2c5a443dc4da8b6177a50cec908ee

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Akademický článek

Enzymatic and Molecular Characterization of Anti-Leishmania Molecules That Differently Target Leishmania and Mammalian eIF4A Proteins, LieIF4A and eIF4AMus

Autor: Yosser Zina Abdelkrim, Emna Harigua-Souiai, Imen Bassoumi-Jamoussi, Mourad Barhoumi, Josette Banroques, Khadija Essafi-Benkhadir, Michael Nilges, Arnaud Blondel, N. Kyle Tanner, Ikram Guizani

Publikováno v: Molecules, Vol 27, Iss 18, p 5890 (2022)

Previous investigations of the Leishmania infantum eIF4A-like protein (LieIF4A) as a potential drug target delivered cholestanol derivatives inhibitors. Here, we investigated the mode of action of cholesterol derivatives as a novel scaffold structure

Externí odkaz: https://doaj.org/article/dd3b2dc394d34a8a8f9fc27de5aab333

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Akademický článek

Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A.

Autor: Emna Harigua-Souiai, Yosser Zina Abdelkrim, Imen Bassoumi-Jamoussi, Ons Zakraoui, Guillaume Bouvier, Khadija Essafi-Benkhadir, Josette Banroques, Nathan Desdouits, Hélène Munier-Lehmann, Mourad Barhoumi, N Kyle Tanner, Michael Nilges, Arnaud Blondel, Ikram Guizani

Publikováno v: PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006160 (2018)

Leishmaniases are neglected parasitic diseases in spite of the major burden they inflict on public health. The identification of novel drugs and targets constitutes a research priority. For that purpose we used Leishmania infantum initiation factor 4

Externí odkaz: https://doaj.org/article/ebb7e2223ed14d3b805b46d2c9ede416

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Known Inhibitors of RNA Helicases and Their Therapeutic Potential

Autor: N. Kyle Tanner, Josette Banroques, Yosser Zina Abdelkrim

Publikováno v: RNA Remodeling Proteins (Methods in Molecular Biology)
RNA Remodeling Proteins (Methods in Molecular Biology), pp.35-52, 2021, ⟨10.1007/978-1-0716-0935-4_3⟩
Methods in Molecular Biology ISBN: 9781071609347

RNA helicases are proteins found in all kingdoms of life, and they are associated with all processes involving RNA from transcription to decay. They use NTP binding and hydrolysis to unwind duplexes, to remodel RNA structures and protein-RNA complexe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f80eeea47937bce98103bb1f03cc3a56
https://hal.archives-ouvertes.fr/hal-03017727

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The In Silico Identification of Potential Members of the Ded1/DDX3 Subfamily of DEAD-Box RNA Helicases from the Protozoan Parasite Leishmania infantum and Their Analyses in Yeast

Autor: Hilal Yeter-Alat, Ikram Guizani, Yosser Zina Abdelkrim, Rafeh Oualha, Mourad Barhoumi, Emmeline Huvelle, N. Kyle Tanner, Molka Mokdadi, Josette Banroques

Publikováno v: Genes
Volume 12
Issue 2
Genes, MDPI, 2021, 12 (2), pp.212. ⟨10.3390/genes12020212⟩
Genes, Vol 12, Iss 212, p 212 (2021)

International audience; DEAD-box RNA helicases are ubiquitous proteins found in all kingdoms of life and that are associated with all processes involving RNA. Their central roles in biology make these proteins potential targets for therapeutic or pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622edaf6781a6147a1c335ce97b3d9eb

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The

Autor: Molka, Mokdadi, Yosser Zina, Abdelkrim, Josette, Banroques, Emmeline, Huvelle, Rafeh, Oualha, Hilal, Yeter-Alat, Ikram, Guizani, Mourad, Barhoumi, N Kyle, Tanner

Publikováno v: Genes

DEAD-box RNA helicases are ubiquitous proteins found in all kingdoms of life and that are associated with all processes involving RNA. Their central roles in biology make these proteins potential targets for therapeutic or prophylactic drugs. The Ded

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e913a4fd92b3100cbc5cfef5bb83c59f
https://pubmed.ncbi.nlm.nih.gov/33535521

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Known Inhibitors of RNA Helicases and Their Therapeutic Potential

Autor: Yosser Zina, Abdelkrim, Josette, Banroques, N, Kyle Tanner

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2209

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::830f7b42eb6ef65f8565ce68acdad3ca
https://pubmed.ncbi.nlm.nih.gov/33201461

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The steroid derivative 6-aminocholestanol inhibits the DEAD-box helicase eIF4A (LieIF4A) from the Trypanosomatid parasite Leishmania by perturbing the RNA and ATP binding sites

Autor: N. Kyle Tanner, Mourad Barhoumi, Emna Harigua-Souiai, Arnaud Blondel, Josette Banroques, Yosser Zina Abdelkrim, Ikram Guizani

Publikováno v: Molecular and Biochemical Parasitology
Molecular and Biochemical Parasitology, 2018, 226, pp.9-19. ⟨10.1016/j.molbiopara.2018.10.001⟩
Molecular and Biochemical Parasitology, Elsevier, 2018, 226, pp.9-19. ⟨10.1016/j.molbiopara.2018.10.001⟩

International audience; The antifungal agent 6-aminocholestanol targets the production of ergosterol, which is the principle sterol in many fungi and protozoans; ergosterol serves many of the same roles as cholesterol in animals. We found that it als

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1cab00f461442b882b9cc5b78e1a41
https://doi.org/10.1016/j.molbiopara.2018.10.001

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Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A

Autor: Imen Bassoumi-Jamoussi, Guillaume Bouvier, Michael Nilges, Mourad Barhoumi, N. Kyle Tanner, Josette Banroques, Arnaud Blondel, Ikram Guizani, Nathan Desdouits, Khadija Essafi-Benkhadir, Hélène Munier-Lehmann, Emna Harigua-Souiai, Yosser Zina Abdelkrim, Ons Zakraoui

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Public Library of Science, 2018, 12 (1), pp.e0006160. ⟨10.1371/journal.pntd.0006160⟩
PLoS Neglected Tropical Diseases, 2018, 12 (1), pp.e0006160. ⟨10.1371/journal.pntd.0006160⟩
PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006160 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0672f598131f3a814de19e5a2c66f228
https://hal-pasteur.archives-ouvertes.fr/pasteur-01968424

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