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Topological dynamics of an intrinsically disordered N-terminal domain of the human androgen receptor
Autor:
Vahid Sheikhhassani, Barbara Scalvini, Julian Ng, Laurens W. H. J. Heling, Yosri Ayache, Tom M. J. Evers, Eva Estébanez‐Perpiñá, Iain J. McEwan, Alireza Mashaghi
Publikováno v:
Protein Science, 31(6):e4334. Wiley
Human androgen receptor contains a large N-terminal domain (AR-NTD) that is highly dynamic and this poses a major challenge for experimental and computational analysis to decipher its conformation. Misfolding of the AR-NTD is implicated in prostate c