Výsledky vyhledávání - "Yosra M. Magdy"

Reduction in TNF alpha and oxidative stress by liraglutide: Impact on ketamine-induced cognitive dysfunction and hyperlocomotion in rats

Autor: Yosra M. Magdy, Amina Ahmed Sedky

Publikováno v: Life sciences. 278

Background Diabetes and psychotic disorders are occasionally comorbid. Possible pathophysiologies linking these disorders include inflammation and oxidative stress. Glucagon like peptide-1 (GLP-1) agonists modulate glucose metabolism and may exert ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24d3a9959750bd516d42b7b3e7c21f5
https://pubmed.ncbi.nlm.nih.gov/33891942

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Amisulpride alleviates chronic mild stress-induced cognitive deficits: Role of prefrontal cortex microglia and Wnt/β-catenin pathway

Autor: Yosra M. Magdy, Sawsan Aboul-Fotouh, Sahar M. Abdelraouf, Mai A. Ebeid, Mohamed Z. Habib, Yasser el Faramawy, Ahmed M Mohamed

Publikováno v: European journal of pharmacology. 885

Accumulating evidence indicates the role of microglial activation and sustained neuroinflammation in the pathogenesis of cognitive dysfunction, a common feature associated with depressive disorders. It also indicates the role of Wnt/β-catenin pathwa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0117829949d3b0d4dd3a6d8b5e6830
https://pubmed.ncbi.nlm.nih.gov/32800810

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The potential benefit of combined versus monotherapy of coenzyme Q10 and fluoxetine on depressive-like behaviors and intermediates coupled to Gsk-3β in rats

Autor: Nevien Hendawy, Yosra M. Magdy, Sally A. Abuelezz

Publikováno v: Toxicology and Applied Pharmacology. 340:39-48

As a part of the serotoninergic dysfunction implicated in neurobiology of depression, evidence has focused on serotonin (5-HT) receptors downstream signaling intermediates including glycogen synthase kinase-3β (GSK-3β), cAMP response element bindin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b14b51236074dc8bb4caae06c67daaf4
https://doi.org/10.1016/j.taap.2017.12.018

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Modulation of hippocampal TLR4/BDNF signal pathway using probiotics is a step closer towards treating cognitive impairment in NASH model

Autor: Yosra M. Magdy, Dalia Aa. El-Waseef, Enas Samir Nabih, Omnyah A. El-Kharashi, Safaa K. Mohammed, Mohamed A. Hamouda

Publikováno v: Physiologybehavior. 214

Disturbance of gut microbiota plays a role in induction and progression of non alcoholic steatohepatitis (NASH) and the associated cognitive dysfunction. We supposed that high fat diet (HFD)-induced dysbiosis may lead to NASH/cognitive impairment co-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb28319f0fb03bc1179f8037e97e0e0
https://pubmed.ncbi.nlm.nih.gov/31786271

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Involvement of TLR4/ CXCL9/ PREX-2 pathway in the development of hepatocellular carcinoma (HCC) and the promising role of early administration of lactobacillus plantarum in Wistar rats

Autor: Enas Samir Nabih, Ghada Galal Hamam, Asmaa M. Elshaer, Abeer A. Abd El Samad, Omnyah A. El-Kharashi, Yosra M. Magdy

Publikováno v: Tissuecell. 60

Abstarct Background and aim Improvement of gut microbiota may help in preventing the progression of cirrhosis. We supposed that Lactobacillus Plantarum (L. Plantarum) protects the cirrhotic liver through suppression of TLR4/ CXCL9/ PREX-2. Methodolog

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https://pubmed.ncbi.nlm.nih.gov/31582017

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Tadalafil versus linaclotide in gastrointestinal dysfunction and depressive behavior in constipation–predominant irritable bowel syndrome

Autor: Amina Ahmed Sedky, Yosra M. Magdy

Publikováno v: Life Sciences. 256:117960

Background Intestinal GC-C/cGMP pathway may be involved in visceral hypersensitivity and fluid secretion in irritable bowel syndrome (IBS). The guanylcyclase C agonist linaclotide, approved for IBS- constipation, is contraindicated in children as it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697f0954f6afed77b9766c9742376714
https://doi.org/10.1016/j.lfs.2020.117960

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Insights into hepatic and renal FXR/DDAH-1/eNOS pathway and its role in the potential benefit of rosuvastatin and silymarin in hepatic nephropathy

Autor: Enas Samir Nabih, Dalia Alaa El-Din Aly El-Waseef, Yosra M. Magdy, Omnyah A. El-Kharashi, Abeer A. Abd El Samad

Publikováno v: Experimental and molecular pathology. 105(3)

Objectives The repression of renal Farnesoid X Receptor (FXR) had been shown to result from lack of bile acid production from cirrhotic liver. We hypothesized that silymarin and rosuvastatin (Rvs) could have a hepatorenal therapeutic effects in hepat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484831556528ff664431b0a4c02f3e17
https://pubmed.ncbi.nlm.nih.gov/30308196

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Histological study on the effect of metformin on high-fat-diet-induced liver injury in adult male albino rats

Autor: Lobna Abdel-Aziz, Omnia A. Alkharashy, Yosra M. Magdy, Sawsan A. El-Said, Safaa M. Shaker, Enas S. Nabeeh

Publikováno v: The Egyptian Journal of Histology. 37:592-602

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https://doi.org/10.1097/01.ehx.0000452726.54766.93

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Potential involvement of JNK1 repression in the hepatic effect of sitagliptin and metformin in rats subjected to high fat diet and chronic mild distress

Autor: Sawsan Aboul-Fotouh, Omnyah A. El-Kharashi, Lobna Abdel-Aziz, Yosra M. Magdy, Safaa M. Shaker, Enas Samir Nabih

Publikováno v: Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 85

Background Depression and non-alcoholic steatohepatitis (NASH) are highly co-morbid, and hepatic JNK pathway may be involved in their relation. Aim To evaluate the impact of depression on NASH through the involvement of JNK1 and to assess the effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b440e80cb1be56ee8bb330fd779aaa1
https://pubmed.ncbi.nlm.nih.gov/27916420

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Targeting Oxidative Stress, Cytokines and Serotonin Interactions Via Indoleamine 2, 3 Dioxygenase by Coenzyme Q10: Role in Suppressing Depressive Like Behavior in Rats

Autor: Yosra M. Magdy, Nevien Hendawy, Sally A. Abuelezz

Publikováno v: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 12(2)

Depression is a major health problem in which oxidative stress and inflammation are inextricably connected in its pathophysiology. Coenzyme Q10 (CoQ10) is an important anti-oxidant compound with anti-inflammatory and neuro-protective properties. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e400e3aa4d6e48bd8f5606d70e5d5880
https://pubmed.ncbi.nlm.nih.gov/27730347

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