Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Yosra A. Muhammad"'
Autor:
Abdelsattar M. Omar, Maan T. Khayat, Farid Ahmed, Yosra A. Muhammad, Azizah M. Malebari, Sara M. Ibrahim, Mohammad I. Khan, Dhaval K. Shah, Wayne E. Childers, Moustafa E. El-Araby
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Tirbanibulin (KX2-391, KX-01), a dual non-ATP (substrate site) Src kinase and tubulin-polymerization inhibitor, demonstrated a universal anti-cancer activity for variety of cancer types. The notion that KX2-391 is a highly selective Src kinase inhibi
Externí odkaz:
https://doaj.org/article/74f0539c28fe4afaab248255f807b3c2
Autor:
Maan T. Khayat, Abdelsattar M. Omar, Farid Ahmed, Mohammad I. Khan, Sara M. Ibrahim, Yosra A. Muhammad, Azizah M. Malebari, Thikryat Neamatallah, Moustafa E. El-Araby
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Structural changes of small-molecule drugs may bring interesting biological properties, especially in the field of kinase inhibitors. We sought to study tirbanibulin, a first-in-class dual Src kinase (non-ATP competitive)/tubulin inhibitor because th
Externí odkaz:
https://doaj.org/article/539bc391ade147b39a5632057cf3fa93
Autor:
Maan T. Khayat, Abdelsattar M. Omar, Mahmoud A. Elfaky, Yosra A. Muhammad, Elaf A. Felemban, Khalid M. El-Say, Moustafa E. El-Araby
Publikováno v:
Heteroatom Chemistry, Vol 2022 (2022)
Chronic Hepatitis C is a global health threat and a silent killer. Regardless of the profound progress in preventing and treating this disease, research continues to discover new direct antiviral agents (DAAs), especially against novel targets. Our r
Externí odkaz:
https://doaj.org/article/320200ef08d44feba563a7dac4ce48f5
Autor:
Sabrin R. M. Ibrahim, Abdelsattar M. Omar, Yosra A. Muhammad, Ali A. Alqarni, Abdullah M. Alshehri, Shaimaa G. A. Mohamed, Hossam M. Abdallah, Mahmoud A. Elfaky, Gamal A. Mohamed, Jianbo Xiao
Publikováno v:
Molecules, Vol 27, Iss 20, p 6797 (2022)
Phenaloenones are structurally unique aromatic polyketides that have been reported in both microbial and plant sources. They possess a hydroxy perinaphthenone three-fused-ring system and exhibit diverse bioactivities, such as cytotoxic, antimicrobial
Externí odkaz:
https://doaj.org/article/0b4184afcfc04934b929f6d57d484d76
Autor:
Sabrin R. M. Ibrahim, Alaa A. Bagalagel, Reem M. Diri, Ahmad O. Noor, Hussain T. Bakhsh, Yosra A. Muhammad, Gamal A. Mohamed, Abdelsattar M. Omar
Publikováno v:
Journal of Fungi, Vol 8, Iss 5, p 443 (2022)
Cancer represents one of the most prevalent causes of global death. CK2 (casein kinase 2) activation boosted cancer proliferation and progression. Therefore, CK2 inhibition can have a crucial role in prohibiting cancer progression and enhancing apopt
Externí odkaz:
https://doaj.org/article/ccfc459c41b44bc6b04769c7a312e286
Autor:
Tarek A. Ahmed, Khalid M. El-Say, Fathy I. Abd-Allah, Abdelsattar M. Omar, Moustafa E. El-Araby, Yosra A. Muhammad, Piyusha P. Pagare, Yan Zhang, Khadijah A. Mohmmad, Osheiza Abdulmalik, Martin K. Safo
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1148 (2021)
Background: Aromatic aldehydes, with their ability to increase the oxygen affinity of sickle hemoglobin, have become important therapeutic agents for sickle cell disease (SCD). One such compound, voxelotor, was recently approved for SCD treatment. Me
Externí odkaz:
https://doaj.org/article/53b06f2a01054c37bbf3132feeae3703
Autor:
Abdelsattar M. Omar, Osheiza Abdulmalik, Mohini S. Ghatge, Yosra A. Muhammad, Steven D. Paredes, Moustafa E. El-Araby, Martin K. Safo
Publikováno v:
Biomolecules, Vol 10, Iss 11, p 1508 (2020)
Aromatic aldehydes that bind to sickle hemoglobin (HbS) to increase the protein oxygen affinity and/or directly inhibit HbS polymer formation to prevent the pathological hypoxia-induced HbS polymerization and the subsequent erythrocyte sickling have
Externí odkaz:
https://doaj.org/article/b3322b5bdc3b4c949d8736deafb25c05
Autor:
Sameh S. Elhady, Enas E. Eltamany, Amera E. Shaaban, Alaa A. Bagalagel, Yosra A. Muhammad, Norhan M. El-Sayed, Seif N. Ayyad, Amal A. M. Ahmed, Mohamed S. Elgawish, Safwat A. Ahmed
Publikováno v:
Plants, Vol 9, Iss 8, p 1031 (2020)
Phytochemical study of Chiliadenus montanus aerial parts afforded six compounds; Intermedeol (1), 5α-hydroperoxy-β-eudesmol (2), 5,7-dihydroxy-3,3’,4’-trimethoxyflavone (3), 5,7,4’-trihydroxy-3,6,3’-trimethoxyflavone (jaceidin) (4), eudesm-
Externí odkaz:
https://doaj.org/article/98388bdeb9474167b51209195e0c0299
Autor:
Maan T. Khayat, Hany E. A. Ahmed, Abdelsattar M. Omar, Yosra A. Muhammad, Khadijah A. Mohammad, Azizah M. Malebari, Ahdab N. Khayyat, Ahmed H. Halawa, Hamada S. Abulkhair, Ahmed A. Al-Karmalawy, Mohammed Almaghrabi, Majed Alharbi, Anfal S. Aljahdali, Ahmed M. El-Agrody
Publikováno v:
Journal of Biomolecular Structure and Dynamics. :1-19
All the previously reported phenylpyrazoles as carbonic anhydrase inhibitors (CAIs) were found to have small sizes and high levels of flexibility, and hence showed low selectivity profiles toward a particular isoform of CA. Herein, we report the deve
Autor:
Azizah M. Malebari, Hany E. A. Ahmed, Saleh K. Ihmaid, Abdelsattar M. Omar, Yosra A. Muhammad, Sultan S. Althagfan, Naif Aljuhani, Abdel-Aziz A. A. El-Sayed, Ahmed H. Halawa, Heba M. El-Tahir, Safaa A. Turkistani, Mohammed Almaghrabi, Ahmed K. B. Aljohani, Ahmed M. El-Agrody, Hamada S. Abulkhair
Publikováno v:
Bioorganic chemistry. 130
COVID-19 and associated substantial inflammations continue to threaten humankind triggering death worldwide. So, the development of new effective antiviral and anti-inflammatory medications is a major scientific goal. Pyranopyrazoles have occupied a