Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction

Autor: Lukas S. Tombor, David John, Simone F. Glaser, Guillermo Luxán, Elvira Forte, Milena Furtado, Nadia Rosenthal, Nina Baumgarten, Marcel H. Schulz, Janina Wittig, Eva-Maria Rogg, Yosif Manavski, Ariane Fischer, Marion Muhly-Reinholz, Kathrin Klee, Mario Looso, Carmen Selignow, Till Acker, Sofia-Iris Bibli, Ingrid Fleming, Ralph Patrick, Richard P. Harvey, Wesley T. Abplanalp, Stefanie Dimmeler

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Endothelial cells play a critical role in the adaptation of tissues to injury and show a remarkable plasticity. Here the authors show, using single cell sequencing, that endothelial cells acquire a transient mesenchymal state associated with metaboli

Externí odkaz: https://doaj.org/article/1006b6d795e44cc8b2756328c762cb7b

Biglycan evokes autophagy in macrophages via a novel CD44/Toll-like receptor 4 signaling axis in ischemia/reperfusion injury

Autor: Ralf P. Brandes, Christian Münch, Yosif Manavski, Liliana Schaefer, Louise Tzung-Harn Hsieh, Renato V. Iozzo, Heiko Roedig, Madalina-Viviana Nastase, Ernst H. K. Stelzer, Jonas B. Michaelis, Chiara Poluzzi, André Bleich, Eva Miriam Buhl, Malgorzata Wygrecka, Ivan Dikic, Christian Brandts, Flávia Rezende, Jinyang Zeng-Brouwers, Josef Pfeilschifter, Peter Boor

Publikováno v: Kidney International. 95:540-562

Biglycan, a small leucine-rich proteoglycan, acts as a danger signal and is classically thought to promote macrophage recruitment via Toll-like receptors (TLR) 2 and 4. We have recently shown that biglycan signaling through TLR 2/4 and the CD14 co-re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b12bf2e91dda29e8c1c1c297a263f5e
https://doi.org/10.1016/j.kint.2018.10.037

Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D

Autor: Konstantin Stark, Stefanie Dimmeler, Kavi Devraj, Markus Hecker, Thomas Korff, David Kaluza, Shemsi Demolli, Tina Lucas, Stefan Liebner, Steffen Massberg, Annekathrin Eckart, Yosif Manavski, Christoph M. Zehendner, Reinier A. Boon, Anuradha Doddaballapur

Publikováno v: Cardiovascular Research, 113(6), 681-691. Oxford University Press
Demolli, S, Doddaballapur, A, Devraj, K, Stark, K, Manavski, Y, Eckart, A, Zehendner, C M, Lucas, T, Korff, T, Hecker, M, Massberg, S, Liebner, S, Kaluza, D, Boon, R A & Dimmeler, S 2017, ' Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D ', Cardiovascular Research, vol. 113, no. 6, pp. 681-691 . https://doi.org/10.1093/cvr/cvx032

Aims Vessel maturation involves the recruitment of mural cells such as pericytes and smooth muscle cells. Laminar shear stress is a major trigger for vessel maturation, but the molecular mechanisms by which shear stress affects recruitment of pericyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b06488931bf935646ad707bfefa237
http://www.scopus.com/inward/record.url?scp=85019114670&partnerID=8YFLogxK

Laminar Shear Stress Inhibits Endothelial Cell Metabolism via KLF2-Mediated Repression of PFKFB3

Autor: Yosif Manavski, Wei Chen, Anuradha Doddaballapur, Katharina M. Michalik, Riekelt H. Houtkooper, Xintian You, Andreas M. Zeiher, Tina Lucas, Michael Potente, Stefanie Dimmeler, Reinier A. Boon

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology, 35(1), 137-145. Lippincott Williams and Wilkins
Doddaballapur, A, Michalik, K M, Manavski, Y, Lucas, T, Houtkooper, R H, You, X, Chen, W, Zeiher, A M, Potente, M, Dimmeler, S & Boon, R A 2015, ' Laminar shear stress inhibits endothelial cell metabolism via KLF2-mediated repression of PFKFB3 ', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 35, no. 1, pp. 137-145 . https://doi.org/10.1161/ATVBAHA.114.304277
Arteriosclerosis, Thrombosis, and Vascular Biology, 35(1), 137-145. Lippincott Williams and Wilkins

Objective— Cellular metabolism was recently shown to regulate endothelial cell phenotype profoundly. Whether the atheroprotective biomechanical stimulus elicited by laminar shear stress modulates endothelial cell metabolism is not known. Approach a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ded00effb3245541862c5b5320c555
https://doi.org/10.1161/atvbaha.114.304277

Long Noncoding RNA MALAT1 Regulates Endothelial Cell Function and Vessel Growth

Autor: Yosif Manavski, Shizuka Uchida, Yuliya Ponomareva, Xintian You, David John, Martin Zörnig, Wei Chen, Reinier A. Boon, Anuradha Doddaballapur, Thomas Braun, Katharina M. Michalik, Stefanie Dimmeler

Publikováno v: Circulation Research, 114(9), 1389-1397. Lippincott Williams and Wilkins
Circulation Research
Michalik, K M, You, X, Manavski, Y, Doddaballapur, A, Zörnig, M, Braun, T, John, D, Ponomareva, Y, Chen, W, Uchida, S, Boon, R A & Dimmeler, S 2014, ' Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth ', Circulation Research, vol. 114, no. 9, pp. 1389-1397 . https://doi.org/10.1161/CIRCRESAHA.114.303265

Rationale: The human genome harbors a large number of sequences encoding for RNAs that are not translated but control cellular functions by distinct mechanisms. The expression and function of the longer transcripts namely the long noncoding RNAs in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564d7ca4016234253e3a598ef18a33d9
https://doi.org/10.1161/circresaha.114.303265