Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Yoshiyuki Yamaura"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 7, Pp 919-933 (2022)
Abstract P‐glycoprotein (P‐gp) is an efflux transporter that plays an important role in the pharmacokinetics of its substrate, and P‐gp activities can be altered by induction and inhibition effects of rifampicin. This study aimed to establish a
Externí odkaz:
https://doaj.org/article/e6a97b922e4e449b9a462a841fb6ee54
Autor:
Tatsuki Mochizuki, Yasunori Aoki, Takashi Yoshikado, Kenta Yoshida, Yurong Lai, Hideki Hirabayashi, Yoshiyuki Yamaura, Kevin Rockich, Kunal Taskar, Tadayuki Takashima, Xiaoyan Chu, Maciej J. Zamek‐Gliszczynski, Jialin Mao, Kazuya Maeda, Kenichi Furihata, Yuichi Sugiyama, Hiroyuki Kusuhara
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 6, Pp 1519-1531 (2022)
Abstract The accurate prediction of OATP1B‐mediated drug–drug interactions (DDIs) is challenging for drug development. Here, we report a physiologically‐based pharmacokinetic (PBPK) model analysis for clinical DDI data generated in heathy subje
Externí odkaz:
https://doaj.org/article/3aee0ecb9abb40628d9f8c6327bcb5a4
Autor:
Kazuo Takayama, Ryosuke Negoro, Tomoki Yamashita, Kanae Kawai, Moe Ichikawa, Takanori Mori, Noriyuki Nakatsu, Kazuo Harada, Sumito Ito, Hiroshi Yamada, Yoshiyuki Yamaura, Kazumasa Hirata, Seiichi Ishida, Hiroyuki Mizuguchi
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 3, Pp 513-526 (2019)
Background & aims: To develop an effective and safe orally administered drug, it is important to predict its intestinal absorption rate, intestinal first-pass effect, and drug-drug interactions of orally administered drugs. However, there is no exist
Externí odkaz:
https://doaj.org/article/a5350c356a974b62a90fa723f7affb0a
Autor:
Tatsuki Mochizuki, Maciej J. Zamek‐Gliszczynski, Kenta Yoshida, Jialin Mao, Kunal Taskar, Hideki Hirabayashi, Xiaoyan Chu, Yurong Lai, Tadayuki Takashima, Kevin Rockich, Yoshiyuki Yamaura, Kaku Fujiwara, Tadahaya Mizuno, Kazuya Maeda, Kenichi Furihata, Yuichi Sugiyama, Hiroyuki Kusuhara
Publikováno v:
Clinical Pharmacology & Therapeutics. 111:1315-1323
This study was designed to assess the quantitative performance of endogenous biomarkers for organic anion transporting polypeptide (OATP) 1B1/1B3-mediated drug-drug interactions (DDIs). Ten healthy volunteers orally received OATP1B1/1B3 probe cocktai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe49ca943b27de4a6141c77e320bebb6
https://doi.org/10.1002/cpt.2584
https://doi.org/10.1002/cpt.2584
Autor:
Ryo Ito, Hanae Morio, Tomoyo Baba, Yasuyuki Sakaguchi, Naomi Wakayama, Ryuto Isogai, Yoshiyuki Yamaura, Takafumi Komori, Tomomi Furihata
Publikováno v:
Pharmaceutical Research. 39:1575-1586
In vitro human blood-brain barrier (BBB) models in combination with central nervous system-physiologically based pharmacokinetic (CNS-PBPK) modeling, hereafter referred to as the "BBB/PBPK" method, are expected to contribute to prediction of brain dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1d33e98b9603afb46ded683caddf9bd
https://doi.org/10.1007/s11095-022-03189-y
https://doi.org/10.1007/s11095-022-03189-y
Autor:
Kenta Kono, Rui Fujimura, Yuka Nakamura, Kanoko Matsuura, Ken-ichi Nunoya, Yoshiyuki Yamaura, Haruo Imawaka, Hiroshi Watanabe, Toru Maruyama
Publikováno v:
Molecular Pharmaceutics. 19:798-804
In human plasma, the main agent of hydrolysis of the ester-type prodrug of levodopa, designated ONO-2160, is alpha-1-acid glycoprotein (AGP), which is a mixture of the F1*S and A variants at molar ratios of 3:1 to 2:1. In this study, the mechanism of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3924bd523d22919a13f657bf881071da
https://doi.org/10.1021/acs.molpharmaceut.1c00614
https://doi.org/10.1021/acs.molpharmaceut.1c00614
Autor:
Keita Kitamura, Ayaka Okamoto, Hanae Morio, Ryuto Isogai, Ryo Ito, Yoshiyuki Yamaura, Saki Izumi, Takafumi Komori, Shingo Ito, Sumio Ohtsuki, Hidetaka Akita, Tomomi Furihata
Publikováno v:
Molecular pharmaceutics. 19(8)
Blood-brain barrier (BBB)-permeable middle- or macromolecules (middle/macromolecules) have recently attracted significant attention as new drug delivery carriers into the human brain via receptor-mediated transcytosis (RMT). During the development pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d023503d0f1baa306d3bbf663e609d
https://pubmed.ncbi.nlm.nih.gov/35766901
https://pubmed.ncbi.nlm.nih.gov/35766901
Publikováno v:
Xenobiotica. 50:526-535
1. Immunodeficient chimeric mice with humanised liver have been useful in predicting total clearance values of drugs in humans. However, their usefulness may currently be limited for specific compounds with interspecies differences.2. In vivo total c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a217aec44af5389af891b9b73d01362b
https://doi.org/10.1080/00498254.2019.1664791
https://doi.org/10.1080/00498254.2019.1664791
Autor:
Tomoki Yamashita, Seiichi Ishida, Hiroshi Yamada, Hiroyuki Mizuguchi, Kazuo Harada, Moe Ichikawa, Kazuo Takayama, Kazumasa Hirata, Kanae Kawai, Noriyuki Nakatsu, Ryosuke Negoro, Yoshiyuki Yamaura, Takanori Mori, Sumito Ito
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 8, Iss 3, Pp 513-526 (2019)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & aims To develop an effective and safe orally administered drug, it is important to predict its intestinal absorption rate, intestinal first-pass effect, and drug-drug interactions of orally administered drugs. However, there is no existi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836b9fc4e81bc0f2d53e50d6ad87bcd2
http://www.sciencedirect.com/science/article/pii/S2352345X19300827
http://www.sciencedirect.com/science/article/pii/S2352345X19300827
Autor:
Yoshiyuki Yamaura, Maeda Hitoshi, Jing Bi, Toru Takeo, Haruo Imawaka, Yuka Nakamura, Toru Maruyama, Hiroshi Watanabe, Ayumi Mukunoki, Ken-ichi Nunoya, Naomi Nakagata, Kenta Kono
Publikováno v:
Molecular Pharmaceutics. 19:3450-3450
Previously, we found that ONO-2160, an ester-type prodrug of levodopa (3-hydroxy-l-tyrosine), was mainly hydrolyzed in human plasma by α1-acid glycoprotein (AGP) with a partial contribution of albumin. In this study, we investigated whether ONO-2160
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f72ef2c6233aa371439f0a1b04ef3a
https://doi.org/10.1021/acs.molpharmaceut.2c00598
https://doi.org/10.1021/acs.molpharmaceut.2c00598